These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

185 related articles for article (PubMed ID: 24160919)

  • 1. Kinetic solvent isotope effect in human P450 CYP17A1-mediated androgen formation: evidence for a reactive peroxoanion intermediate.
    Gregory MC; Denisov IG; Grinkova YV; Khatri Y; Sligar SG
    J Am Chem Soc; 2013 Nov; 135(44):16245-7. PubMed ID: 24160919
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Mechanism of the Clinically Relevant E305G Mutation in Human P450 CYP17A1.
    Liu Y; Grinkova Y; Gregory MC; Denisov IG; Kincaid JR; Sligar SG
    Biochemistry; 2021 Nov; 60(43):3262-3271. PubMed ID: 34662099
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Active site proton delivery and the lyase activity of human CYP17A1.
    Khatri Y; Gregory MC; Grinkova YV; Denisov IG; Sligar SG
    Biochem Biophys Res Commun; 2014 Jan; 443(1):179-84. PubMed ID: 24299954
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Cytochrome b
    Duggal R; Denisov IG; Sligar SG
    FEBS Lett; 2018 Jul; 592(13):2282-2288. PubMed ID: 29888793
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Solvent isotope effects in the catalytic cycle of P450 CYP17A1: Computational modeling of the hydroxylation and lyase reactions.
    Denisov IG; Sligar SG
    J Inorg Biochem; 2023 Jun; 243():112202. PubMed ID: 37004494
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Compound I is the reactive intermediate in the first monooxygenation step during conversion of cholesterol to pregnenolone by cytochrome P450scc: EPR/ENDOR/cryoreduction/annealing studies.
    Davydov R; Gilep AA; Strushkevich NV; Usanov SA; Hoffman BM
    J Am Chem Soc; 2012 Oct; 134(41):17149-56. PubMed ID: 23039857
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Human P450 CYP17A1: Control of Substrate Preference by Asparagine 202.
    Gregory MC; Mak PJ; Khatri Y; Kincaid JR; Sligar SG
    Biochemistry; 2018 Feb; 57(5):764-771. PubMed ID: 29283561
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Unveiling the crucial intermediates in androgen production.
    Mak PJ; Gregory MC; Denisov IG; Sligar SG; Kincaid JR
    Proc Natl Acad Sci U S A; 2015 Dec; 112(52):15856-61. PubMed ID: 26668369
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Identification of new substrates for the CYP106A1-mediated 11-oxidation and investigation of the reaction mechanism.
    Kiss FM; Khatri Y; Zapp J; Bernhardt R
    FEBS Lett; 2015 Aug; 589(18):2320-6. PubMed ID: 26188546
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1.
    Gonzalez E; Guengerich FP
    J Biol Chem; 2017 Aug; 292(32):13168-13185. PubMed ID: 28684414
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Substrate-Specific Allosteric Effects on the Enhancement of CYP17A1 Lyase Efficiency by Cytochrome
    Liu Y; Denisov IG; Sligar SG; Kincaid JR
    J Am Chem Soc; 2021 Mar; 143(10):3729-3733. PubMed ID: 33656879
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Human Cytochrome CYP17A1: The Structural Basis for Compromised Lyase Activity with 17-Hydroxyprogesterone.
    Mak PJ; Duggal R; Denisov IG; Gregory MC; Sligar SG; Kincaid JR
    J Am Chem Soc; 2018 Jun; 140(23):7324-7331. PubMed ID: 29758981
    [TBL] [Abstract][Full Text] [Related]  

  • 13. P450 CYP17A1 Variant with a Disordered Proton Shuttle Assembly Retains Peroxo-Mediated Lyase Efficiency.
    Liu Y; Denisov IG; Grinkova YV; Sligar SG; Kincaid JR
    Chemistry; 2020 Dec; 26(70):16846-16852. PubMed ID: 32681807
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Evidence that cytochrome b5 acts as a redox donor in CYP17A1 mediated androgen synthesis.
    Duggal R; Liu Y; Gregory MC; Denisov IG; Kincaid JR; Sligar SG
    Biochem Biophys Res Commun; 2016 Aug; 477(2):202-8. PubMed ID: 27297105
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Substrate-modulated cytochrome P450 17A1 and cytochrome b5 interactions revealed by NMR.
    Estrada DF; Laurence JS; Scott EE
    J Biol Chem; 2013 Jun; 288(23):17008-17018. PubMed ID: 23620596
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Minor activities and transition state properties of the human steroid hydroxylases cytochromes P450c17 and P450c21, from reactions observed with deuterium-labeled substrates.
    Yoshimoto FK; Zhou Y; Peng HM; Stidd D; Yoshimoto JA; Sharma KK; Matthew S; Auchus RJ
    Biochemistry; 2012 Sep; 51(36):7064-77. PubMed ID: 22873692
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Conformational selection dominates binding of steroids to human cytochrome P450 17A1.
    Guengerich FP; Wilkey CJ; Glass SM; Reddish MJ
    J Biol Chem; 2019 Jun; 294(26):10028-10041. PubMed ID: 31072872
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Mechanism of Cytochrome P450 17A1-Catalyzed Hydroxylase and Lyase Reactions.
    Bonomo S; Jørgensen FS; Olsen L
    J Chem Inf Model; 2017 May; 57(5):1123-1133. PubMed ID: 28387522
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Importance of Asparagine 202 in Manipulating Active Site Structure and Substrate Preference for Human CYP17A1.
    Liu Y; Denisov I; Gregory M; Sligar SG; Kincaid JR
    Biochemistry; 2022 Apr; 61(7):583-594. PubMed ID: 35287432
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Isotope-Labeling Studies Support the Electrophilic Compound I Iron Active Species, FeO(3+), for the Carbon-Carbon Bond Cleavage Reaction of the Cholesterol Side-Chain Cleavage Enzyme, Cytochrome P450 11A1.
    Yoshimoto FK; Jung IJ; Goyal S; Gonzalez E; Guengerich FP
    J Am Chem Soc; 2016 Sep; 138(37):12124-41. PubMed ID: 27571509
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.