BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

292 related articles for article (PubMed ID: 24174400)

  • 1. High-throughput biophysical analysis of protein therapeutics to examine interrelationships between aggregate formation and conformational stability.
    Chaudhuri R; Cheng Y; Middaugh CR; Volkin DB
    AAPS J; 2014 Jan; 16(1):48-64. PubMed ID: 24174400
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Characterization and stabilization of recombinant human protein pentraxin (rhPTX-2).
    Liu J; Blasie CA; Shi S; Joshi SB; Middaugh CR; Volkin DB
    J Pharm Sci; 2013 Mar; 102(3):827-41. PubMed ID: 23160921
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Instability of therapeutic proteins - An overview of stresses, stabilization mechanisms and analytical techniques involved in lyophilized proteins.
    Butreddy A; Janga KY; Ajjarapu S; Sarabu S; Dudhipala N
    Int J Biol Macromol; 2021 Jan; 167():309-325. PubMed ID: 33275971
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Effect of ionic strength and pH on the physical and chemical stability of a monoclonal antibody antigen-binding fragment.
    Wang T; Kumru OS; Yi L; Wang YJ; Zhang J; Kim JH; Joshi SB; Middaugh CR; Volkin DB
    J Pharm Sci; 2013 Aug; 102(8):2520-37. PubMed ID: 23824562
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Development of a candidate stabilizing formulation for bulk storage of a double mutant heat labile toxin (dmLT) protein based adjuvant.
    Toprani VM; Sahni N; Hickey JM; Robertson GA; Middaugh CR; Joshi SB; Volkin DB
    Vaccine; 2017 Oct; 35(41):5471-5480. PubMed ID: 28551040
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Comparison of high-throughput biophysical methods to identify stabilizing excipients for a model IgG2 monoclonal antibody: conformational stability and kinetic aggregation measurements.
    Cheng W; Joshi SB; He F; Brems DN; He B; Kerwin BA; Volkin DB; Middaugh CR
    J Pharm Sci; 2012 May; 101(5):1701-20. PubMed ID: 22323186
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Analytical methods and formulation factors to enhance protein stability in solution.
    Jeong SH
    Arch Pharm Res; 2012 Nov; 35(11):1871-86. PubMed ID: 23212628
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Protein comparability assessments and potential applicability of high throughput biophysical methods and data visualization tools to compare physical stability profiles.
    Alsenaidy MA; Jain NK; Kim JH; Middaugh CR; Volkin DB
    Front Pharmacol; 2014; 5():39. PubMed ID: 24659968
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Hydrogen-deuterium exchange mass spectrometry as an emerging analytical tool for stabilization and formulation development of therapeutic monoclonal antibodies.
    Majumdar R; Middaugh CR; Weis DD; Volkin DB
    J Pharm Sci; 2015 Feb; 104(2):327-45. PubMed ID: 25354868
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Small-angle x-ray scattering screening complements conventional biophysical analysis: comparative structural and biophysical analysis of monoclonal antibodies IgG1, IgG2, and IgG4.
    Tian X; Langkilde AE; Thorolfsson M; Rasmussen HB; Vestergaard B
    J Pharm Sci; 2014 Jun; 103(6):1701-10. PubMed ID: 24700358
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Formulation design and high-throughput excipient selection based on structural integrity and conformational stability of dilute and highly concentrated IgG1 monoclonal antibody solutions.
    Bhambhani A; Kissmann JM; Joshi SB; Volkin DB; Kashi RS; Middaugh CR
    J Pharm Sci; 2012 Mar; 101(3):1120-35. PubMed ID: 22147527
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Effects of solution conditions on methionine oxidation in albinterferon alfa-2b and the role of oxidation in its conformation and aggregation.
    Chou DK; Krishnamurthy R; Manning MC; Randolph TW; Carpenter JF
    J Pharm Sci; 2013 Feb; 102(2):660-73. PubMed ID: 23203978
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Overcoming challenges in co-formulation of proteins with contradicting stability profiles - EPO plus G-CSF.
    Krieg D; Svilenov H; Gitter JH; Winter G
    Eur J Pharm Sci; 2020 Jan; 141():105073. PubMed ID: 31655209
    [TBL] [Abstract][Full Text] [Related]  

  • 14. High-throughput biophysical analysis and data visualization of conformational stability of an IgG1 monoclonal antibody after deglycosylation.
    Alsenaidy MA; Kim JH; Majumdar R; Weis DD; Joshi SB; Tolbert TJ; Middaugh CR; Volkin DB
    J Pharm Sci; 2013 Nov; 102(11):3942-56. PubMed ID: 24114789
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The ReFOLD assay for protein formulation studies and prediction of protein aggregation during long-term storage.
    Svilenov H; Winter G
    Eur J Pharm Biopharm; 2019 Apr; 137():131-139. PubMed ID: 30818009
    [TBL] [Abstract][Full Text] [Related]  

  • 16. High-throughput screening and stability optimization of anti-streptavidin IgG1 and IgG2 formulations.
    Alekseychyk L; Su C; Becker GW; Treuheit MJ; Razinkov VI
    J Biomol Screen; 2014 Oct; 19(9):1290-301. PubMed ID: 25023322
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Chemometrics in Protein Formulation: Stability Governed by Repulsion and Protein Unfolding.
    Kulakova A; Augustijn D; El Bialy I; Gentiluomo L; Greco ML; Hervø-Hansen S; Indrakumar S; Mahapatra S; Martinez Morales M; Pohl C; Polimeni M; Roche A; Svilenov HL; Tosstorff A; Zalar M; Curtis R; Derrick JP; Frieß W; Golovanov AP; Lund M; Nørgaard A; Khan TA; Peters GHJ; Pluen A; Roessner D; Streicher WW; van der Walle CF; Warwicker J; Uddin S; Winter G; Bukrinski JT; Rinnan Å; Harris P
    Mol Pharm; 2023 Jun; 20(6):2951-2965. PubMed ID: 37146162
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Utility of High Throughput Screening Techniques to Predict Stability of Monoclonal Antibody Formulations During Early Stage Development.
    Goldberg DS; Lewus RA; Esfandiary R; Farkas DC; Mody N; Day KJ; Mallik P; Tracka MB; Sealey SK; Samra HS
    J Pharm Sci; 2017 Aug; 106(8):1971-1977. PubMed ID: 28456733
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Preformulation Characterization, Stabilization, and Formulation Design for the Acrylodan-Labeled Glucose-Binding Protein SM4-AC.
    Sahni N; Chaudhuri R; Hickey JM; Manikwar P; D'Souza A; Metters A; Joshi SB; Middaugh CR; Volkin DB
    J Pharm Sci; 2017 May; 106(5):1197-1210. PubMed ID: 28088457
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Multidimensional methods for the formulation of biopharmaceuticals and vaccines.
    Maddux NR; Joshi SB; Volkin DB; Ralston JP; Middaugh CR
    J Pharm Sci; 2011 Oct; 100(10):4171-97. PubMed ID: 21647886
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.