These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
200 related articles for article (PubMed ID: 24175284)
1. The pyridoxal 5'-phosphate (PLP)-dependent enzyme serine palmitoyltransferase (SPT): effects of the small subunits and insights from bacterial mimics of human hLCB2a HSAN1 mutations. Beattie AE; Gupta SD; Frankova L; Kazlauskaite A; Harmon JM; Dunn TM; Campopiano DJ Biomed Res Int; 2013; 2013():194371. PubMed ID: 24175284 [TBL] [Abstract][Full Text] [Related]
2. The external aldimine form of serine palmitoyltransferase: structural, kinetic, and spectroscopic analysis of the wild-type enzyme and HSAN1 mutant mimics. Raman MCC; Johnson KA; Yard BA; Lowther J; Carter LG; Naismith JH; Campopiano DJ J Biol Chem; 2009 Jun; 284(25):17328-17339. PubMed ID: 19376777 [TBL] [Abstract][Full Text] [Related]
3. HSAN1 mutations in serine palmitoyltransferase reveal a close structure-function-phenotype relationship. Bode H; Bourquin F; Suriyanarayanan S; Wei Y; Alecu I; Othman A; Von Eckardstein A; Hornemann T Hum Mol Genet; 2016 Mar; 25(5):853-65. PubMed ID: 26681808 [TBL] [Abstract][Full Text] [Related]
4. A disease-causing mutation in the active site of serine palmitoyltransferase causes catalytic promiscuity. Gable K; Gupta SD; Han G; Niranjanakumari S; Harmon JM; Dunn TM J Biol Chem; 2010 Jul; 285(30):22846-52. PubMed ID: 20504773 [TBL] [Abstract][Full Text] [Related]
5. The structure of serine palmitoyltransferase; gateway to sphingolipid biosynthesis. Yard BA; Carter LG; Johnson KA; Overton IM; Dorward M; Liu H; McMahon SA; Oke M; Puech D; Barton GJ; Naismith JH; Campopiano DJ J Mol Biol; 2007 Jul; 370(5):870-86. PubMed ID: 17559874 [TBL] [Abstract][Full Text] [Related]
6. Novel HSAN1 mutation in serine palmitoyltransferase resides at a putative phosphorylation site that is involved in regulating substrate specificity. Ernst D; Murphy SM; Sathiyanadan K; Wei Y; Othman A; Laurá M; Liu YT; Penno A; Blake J; Donaghy M; Houlden H; Reilly MM; Hornemann T Neuromolecular Med; 2015 Mar; 17(1):47-57. PubMed ID: 25567748 [TBL] [Abstract][Full Text] [Related]
7. Reconstitution of the pyridoxal 5'-phosphate (PLP) dependent enzyme serine palmitoyltransferase (SPT) with pyridoxal reveals a crucial role for the phosphate during catalysis. Beattie AE; Clarke DJ; Wadsworth JM; Lowther J; Sin HL; Campopiano DJ Chem Commun (Camb); 2013 Aug; 49(63):7058-60. PubMed ID: 23814788 [TBL] [Abstract][Full Text] [Related]
8. Structural, mechanistic and regulatory studies of serine palmitoyltransferase. Lowther J; Naismith JH; Dunn TM; Campopiano DJ Biochem Soc Trans; 2012 Jun; 40(3):547-54. PubMed ID: 22616865 [TBL] [Abstract][Full Text] [Related]
9. A Novel Variant (Asn177Asp) in SPTLC2 Causing Hereditary Sensory Autonomic Neuropathy Type 1C. Suriyanarayanan S; Othman A; Dräger B; Schirmacher A; Young P; Mulahasanovic L; Hörtnagel K; Biskup S; von Eckardstein A; Hornemann T; Lone MA Neuromolecular Med; 2019 Jun; 21(2):182-191. PubMed ID: 30955194 [TBL] [Abstract][Full Text] [Related]
10. Mutations in the yeast LCB1 and LCB2 genes, including those corresponding to the hereditary sensory neuropathy type I mutations, dominantly inactivate serine palmitoyltransferase. Gable K; Han G; Monaghan E; Bacikova D; Natarajan M; Williams R; Dunn TM J Biol Chem; 2002 Mar; 277(12):10194-200. PubMed ID: 11781309 [TBL] [Abstract][Full Text] [Related]
11. Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism. Hanada K Biochim Biophys Acta; 2003 Jun; 1632(1-3):16-30. PubMed ID: 12782147 [TBL] [Abstract][Full Text] [Related]
12. Molecular characterization of membrane-associated soluble serine palmitoyltransferases from Sphingobacterium multivorum and Bdellovibrio stolpii. Ikushiro H; Islam MM; Tojo H; Hayashi H J Bacteriol; 2007 Aug; 189(15):5749-61. PubMed ID: 17557831 [TBL] [Abstract][Full Text] [Related]
13. Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1. Garofalo K; Penno A; Schmidt BP; Lee HJ; Frosch MP; von Eckardstein A; Brown RH; Hornemann T; Eichler FS J Clin Invest; 2011 Dec; 121(12):4735-45. PubMed ID: 22045570 [TBL] [Abstract][Full Text] [Related]
14. Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy. McCampbell A; Truong D; Broom DC; Allchorne A; Gable K; Cutler RG; Mattson MP; Woolf CJ; Frosch MP; Harmon JM; Dunn TM; Brown RH Hum Mol Genet; 2005 Nov; 14(22):3507-21. PubMed ID: 16210380 [TBL] [Abstract][Full Text] [Related]
15. Inhibition of the PLP-dependent enzyme serine palmitoyltransferase by cycloserine: evidence for a novel decarboxylative mechanism of inactivation. Lowther J; Yard BA; Johnson KA; Carter LG; Bhat VT; Raman MC; Clarke DJ; Ramakers B; McMahon SA; Naismith JH; Campopiano DJ Mol Biosyst; 2010 Sep; 6(9):1682-93. PubMed ID: 20445930 [TBL] [Abstract][Full Text] [Related]
16. Overexpression of the wild-type SPT1 subunit lowers desoxysphingolipid levels and rescues the phenotype of HSAN1. Eichler FS; Hornemann T; McCampbell A; Kuljis D; Penno A; Vardeh D; Tamrazian E; Garofalo K; Lee HJ; Kini L; Selig M; Frosch M; Gable K; von Eckardstein A; Woolf CJ; Guan G; Harmon JM; Dunn TM; Brown RH J Neurosci; 2009 Nov; 29(46):14646-51. PubMed ID: 19923297 [TBL] [Abstract][Full Text] [Related]
17. Hereditary sensory neuropathy type 1 is caused by the accumulation of two neurotoxic sphingolipids. Penno A; Reilly MM; Houlden H; Laurá M; Rentsch K; Niederkofler V; Stoeckli ET; Nicholson G; Eichler F; Brown RH; von Eckardstein A; Hornemann T J Biol Chem; 2010 Apr; 285(15):11178-87. PubMed ID: 20097765 [TBL] [Abstract][Full Text] [Related]
18. A water-soluble homodimeric serine palmitoyltransferase from Sphingomonas paucimobilis EY2395T strain. Purification, characterization, cloning, and overproduction. Ikushiro H; Hayashi H; Kagamiyama H J Biol Chem; 2001 May; 276(21):18249-56. PubMed ID: 11279212 [TBL] [Abstract][Full Text] [Related]
19. Mutations in the SPTLC2 subunit of serine palmitoyltransferase cause hereditary sensory and autonomic neuropathy type I. Rotthier A; Auer-Grumbach M; Janssens K; Baets J; Penno A; Almeida-Souza L; Van Hoof K; Jacobs A; De Vriendt E; Schlotter-Weigel B; Löscher W; Vondráček P; Seeman P; De Jonghe P; Van Dijck P; Jordanova A; Hornemann T; Timmerman V Am J Hum Genet; 2010 Oct; 87(4):513-22. PubMed ID: 20920666 [TBL] [Abstract][Full Text] [Related]
20. Hereditary sensory neuropathy type 1 mutations confer dominant negative effects on serine palmitoyltransferase, critical for sphingolipid synthesis. Bejaoui K; Uchida Y; Yasuda S; Ho M; Nishijima M; Brown RH; Holleran WM; Hanada K J Clin Invest; 2002 Nov; 110(9):1301-8. PubMed ID: 12417569 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]