BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

156 related articles for article (PubMed ID: 24185126)

  • 1. Effect of human glutathione S-transferase hGSTP1-1 polymorphism on the detoxification of reactive metabolites of clozapine, diclofenac and acetaminophen.
    Dragovic S; Venkataraman H; Begheijn S; Vermeulen NP; Commandeur JN
    Toxicol Lett; 2014 Jan; 224(2):272-81. PubMed ID: 24185126
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Role of human glutathione S-transferases in the inactivation of reactive metabolites of clozapine.
    Dragovic S; Boerma JS; van Bergen L; Vermeulen NP; Commandeur JN
    Chem Res Toxicol; 2010 Sep; 23(9):1467-76. PubMed ID: 20849150
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Effect of human glutathione S-transferases on glutathione-dependent inactivation of cytochrome P450-dependent reactive intermediates of diclofenac.
    Dragovic S; Boerma JS; Vermeulen NP; Commandeur JN
    Chem Res Toxicol; 2013 Nov; 26(11):1632-41. PubMed ID: 24083800
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Reconstitution of the interplay between cytochrome P450 and human glutathione S-transferases in clozapine metabolism in yeast.
    Vredenburg G; Vassell KP; Commandeur JN; Vermeulen NP; Vos JC
    Toxicol Lett; 2013 Oct; 222(3):247-56. PubMed ID: 23916688
    [TBL] [Abstract][Full Text] [Related]  

  • 5. One-electron oxidation of diclofenac by human cytochrome P450s as a potential bioactivation mechanism for formation of 2'-(glutathion-S-yl)-deschloro-diclofenac.
    Boerma JS; Vermeulen NP; Commandeur JN
    Chem Biol Interact; 2014 Jan; 207():32-40. PubMed ID: 24246759
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Differential catalytic efficiency of allelic variants of human glutathione S-transferase Pi in catalyzing the glutathione conjugation of thiotepa.
    Srivastava SK; Singhal SS; Hu X; Awasthi YC; Zimniak P; Singh SV
    Arch Biochem Biophys; 1999 Jun; 366(1):89-94. PubMed ID: 10334868
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Simulation of interindividual differences in inactivation of reactive para-benzoquinone imine metabolites of diclofenac by glutathione S-transferases in human liver cytosol.
    den Braver MW; Zhang Y; Venkataraman H; Vermeulen NP; Commandeur JN
    Toxicol Lett; 2016 Jul; 255():52-62. PubMed ID: 27183920
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Application of drug metabolising mutants of cytochrome P450 BM3 (CYP102A1) as biocatalysts for the generation of reactive metabolites.
    Damsten MC; van Vugt-Lussenburg BM; Zeldenthuis T; de Vlieger JS; Commandeur JN; Vermeulen NP
    Chem Biol Interact; 2008 Jan; 171(1):96-107. PubMed ID: 17996858
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Active site architecture of polymorphic forms of human glutathione S-transferase P1-1 accounts for their enantioselectivity and disparate activity in the glutathione conjugation of 7beta,8alpha-dihydroxy-9alpha,10alpha-ox y-7,8,9,10-tetrahydrobenzo(a)pyrene.
    Hu X; O'Donnell R; Srivastava SK; Xia H; Zimniak P; Nanduri B; Bleicher RJ; Awasthi S; Awasthi YC; Ji X; Singh SV
    Biochem Biophys Res Commun; 1997 Jun; 235(2):424-8. PubMed ID: 9199210
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mass spectrometric characterization of protein adducts of multiple P450-dependent reactive intermediates of diclofenac to human glutathione-S-transferase P1-1.
    Boerma JS; Dragovic S; Vermeulen NP; Commandeur JN
    Chem Res Toxicol; 2012 Nov; 25(11):2532-41. PubMed ID: 22998212
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Role of residue 87 in the activity and regioselectivity of clozapine metabolism by drug-metabolizing CYP102A1 M11H: application for structural characterization of clozapine GSH conjugates.
    Rea V; Dragovic S; Boerma JS; de Kanter FJ; Vermeulen NP; Commandeur JN
    Drug Metab Dispos; 2011 Dec; 39(12):2411-20. PubMed ID: 21890734
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mechanism of differential catalytic efficiency of two polymorphic forms of human glutathione S-transferase P1-1 in the glutathione conjugation of carcinogenic diol epoxide of chrysene.
    Hu X; Ji X; Srivastava SK; Xia H; Awasthi S; Nanduri B; Awasthi YC; Zimniak P; Singh SV
    Arch Biochem Biophys; 1997 Sep; 345(1):32-8. PubMed ID: 9281308
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Human NAD(P)H:quinone oxidoreductase 1 (NQO1)-mediated inactivation of reactive quinoneimine metabolites of diclofenac and mefenamic acid.
    Vredenburg G; Elias NS; Venkataraman H; Hendriks DF; Vermeulen NP; Commandeur JN; Vos JC
    Chem Res Toxicol; 2014 Apr; 27(4):576-86. PubMed ID: 24552538
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Catalytic efficiencies of allelic variants of human glutathione S-transferase P1-1 toward carcinogenic anti-diol epoxides of benzo[c]phenanthrene and benzo[g]chrysene.
    Hu X; Xia H; Srivastava SK; Pal A; Awasthi YC; Zimniak P; Singh SV
    Cancer Res; 1998 Dec; 58(23):5340-3. PubMed ID: 9850062
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Characterization of atrazine biotransformation by human and murine glutathione S-transferases.
    Abel EL; Opp SM; Verlinde CL; Bammler TK; Eaton DL
    Toxicol Sci; 2004 Aug; 80(2):230-8. PubMed ID: 15115887
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Application of CYP102A1M11H as a tool for the generation of protein adducts of reactive drug metabolites.
    Boerma JS; Vermeulen NP; Commandeur JN
    Chem Res Toxicol; 2011 Aug; 24(8):1263-74. PubMed ID: 21639118
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Differential protection against benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced DNA damage in HepG2 cells stably transfected with allelic variants of pi class human glutathione S-transferase.
    Hu X; Herzog C; Zimniak P; Singh SV
    Cancer Res; 1999 May; 59(10):2358-62. PubMed ID: 10344744
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Screening and identification of GSH-trapped reactive metabolites using hybrid triple quadruple linear ion trap mass spectrometry.
    Zheng J; Ma L; Xin B; Olah T; Humphreys WG; Zhu M
    Chem Res Toxicol; 2007 May; 20(5):757-66. PubMed ID: 17402749
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Cytochrome P450-mediated bioactivation of mefenamic acid to quinoneimine intermediates and inactivation by human glutathione S-transferases.
    Venkataraman H; den Braver MW; Vermeulen NP; Commandeur JN
    Chem Res Toxicol; 2014 Dec; 27(12):2071-81. PubMed ID: 25372302
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Differential protection by human glutathione S-transferase P1 against cytotoxicity of benzo[a]pyrene, dibenzo[a,l]pyrene, or their dihydrodiol metabolites, in bi-transgenic cell lines that co-express rat versus human cytochrome P4501A1.
    Kabler SL; Seidel A; Jacob J; Doehmer J; Morrow CS; Townsend AJ
    Chem Biol Interact; 2009 May; 179(2-3):240-6. PubMed ID: 19330882
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.