BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

226 related articles for article (PubMed ID: 24204194)

  • 1. Dependence of tumor cell lines and patient-derived tumors on the NAD salvage pathway renders them sensitive to NAMPT inhibition with GNE-618.
    Xiao Y; Elkins K; Durieux JK; Lee L; Oeh J; Yang LX; Liang X; DelNagro C; Tremayne J; Kwong M; Liederer BM; Jackson PK; Belmont LD; Sampath D; O'Brien T
    Neoplasia; 2013 Oct; 15(10):1151-60. PubMed ID: 24204194
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Supplementation of nicotinic acid with NAMPT inhibitors results in loss of in vivo efficacy in NAPRT1-deficient tumor models.
    O'Brien T; Oeh J; Xiao Y; Liang X; Vanderbilt A; Qin A; Yang L; Lee LB; Ly J; Cosino E; LaCap JA; Ogasawara A; Williams S; Nannini M; Liederer BM; Jackson P; Dragovich PS; Sampath D
    Neoplasia; 2013 Dec; 15(12):1314-29. PubMed ID: 24403854
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Targeting the NAD Salvage Synthesis Pathway as a Novel Therapeutic Strategy for Osteosarcomas with Low NAPRT Expression.
    Franceschini N; Oosting J; Tamsma M; Niessen B; Bruijn IB; van den Akker B; Kruisselbrink AB; Palubeckaitė I; Bovée JVMG; Cleton-Jansen AM
    Int J Mol Sci; 2021 Jun; 22(12):. PubMed ID: 34200964
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Loss of NAPRT1 expression by tumor-specific promoter methylation provides a novel predictive biomarker for NAMPT inhibitors.
    Shames DS; Elkins K; Walter K; Holcomb T; Du P; Mohl D; Xiao Y; Pham T; Haverty PM; Liederer B; Liang X; Yauch RL; O'Brien T; Bourgon R; Koeppen H; Belmont LD
    Clin Cancer Res; 2013 Dec; 19(24):6912-23. PubMed ID: 24097869
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) as a therapeutic strategy in cancer.
    Sampath D; Zabka TS; Misner DL; O'Brien T; Dragovich PS
    Pharmacol Ther; 2015 Jul; 151():16-31. PubMed ID: 25709099
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Metabolic Response to NAD Depletion across Cell Lines Is Highly Variable.
    Xiao Y; Kwong M; Daemen A; Belvin M; Liang X; Hatzivassiliou G; O'Brien T
    PLoS One; 2016; 11(10):e0164166. PubMed ID: 27711204
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Targeting of NAD metabolism in pancreatic cancer cells: potential novel therapy for pancreatic tumors.
    Chini CC; Guerrico AM; Nin V; Camacho-Pereira J; Escande C; Barbosa MT; Chini EN
    Clin Cancer Res; 2014 Jan; 20(1):120-30. PubMed ID: 24025713
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Depletion of the central metabolite NAD leads to oncosis-mediated cell death.
    Del Nagro C; Xiao Y; Rangell L; Reichelt M; O'Brien T
    J Biol Chem; 2014 Dec; 289(51):35182-92. PubMed ID: 25355314
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Targeting the NAD
    Ye C; Qi L; Li X; Wang J; Yu J; Zhou B; Guo C; Chen J; Zheng S
    Cell Commun Signal; 2020 Jan; 18(1):16. PubMed ID: 32005247
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Identification of novel resistance mechanisms to NAMPT inhibition via the de novo NAD
    Guo J; Lam LT; Longenecker KL; Bui MH; Idler KB; Glaser KB; Wilsbacher JL; Tse C; Pappano WN; Huang TH
    Biochem Biophys Res Commun; 2017 Sep; 491(3):681-686. PubMed ID: 28756225
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The NAD(+) salvage pathway modulates cancer cell viability via p73.
    Sharif T; Ahn DG; Liu RZ; Pringle E; Martell E; Dai C; Nunokawa A; Kwak M; Clements D; Murphy JP; Dean C; Marcato P; McCormick C; Godbout R; Gujar SA; Lee PW
    Cell Death Differ; 2016 Apr; 23(4):669-80. PubMed ID: 26586573
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Retinal toxicity, in vivo and in vitro, associated with inhibition of nicotinamide phosphoribosyltransferase.
    Zabka TS; Singh J; Dhawan P; Liederer BM; Oeh J; Kauss MA; Xiao Y; Zak M; Lin T; McCray B; La N; Nguyen T; Beyer J; Farman C; Uppal H; Dragovich PS; O'Brien T; Sampath D; Misner DL
    Toxicol Sci; 2015 Mar; 144(1):163-72. PubMed ID: 25505128
    [TBL] [Abstract][Full Text] [Related]  

  • 13. NAMPT and NAPRT1: novel polymorphisms and distribution of variants between normal tissues and tumor samples.
    Duarte-Pereira S; Silva SS; Azevedo L; Castro L; Amorim A; Silva RM
    Sci Rep; 2014 Sep; 4():6311. PubMed ID: 25201160
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery of a novel nicotinamide phosphoribosyl transferase (NAMPT) inhibitor via in silico screening.
    Takeuchi M; Niimi T; Masumoto M; Orita M; Yokota H; Yamamoto T
    Biol Pharm Bull; 2014; 37(1):31-6. PubMed ID: 24389478
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Identification of the Nicotinamide Salvage Pathway as a New Toxification Route for Antimetabolites.
    Buonvicino D; Mazzola F; Zamporlini F; Resta F; Ranieri G; Camaioni E; Muzzi M; Zecchi R; Pieraccini G; Dölle C; Calamante M; Bartolucci G; Ziegler M; Stecca B; Raffaelli N; Chiarugi A
    Cell Chem Biol; 2018 Apr; 25(4):471-482.e7. PubMed ID: 29478906
    [TBL] [Abstract][Full Text] [Related]  

  • 16. NAD Synthesis Pathway Interference Is a Viable Therapeutic Strategy for Chondrosarcoma.
    Peterse EFP; van den Akker BEWM; Niessen B; Oosting J; Suijker J; de Jong Y; Danen EHJ; Cleton-Jansen AM; Bovée JVMG
    Mol Cancer Res; 2017 Dec; 15(12):1714-1721. PubMed ID: 28860121
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors.
    Watson M; Roulston A; Bélec L; Billot X; Marcellus R; Bédard D; Bernier C; Branchaud S; Chan H; Dairi K; Gilbert K; Goulet D; Gratton MO; Isakau H; Jang A; Khadir A; Koch E; Lavoie M; Lawless M; Nguyen M; Paquette D; Turcotte E; Berger A; Mitchell M; Shore GC; Beauparlant P
    Mol Cell Biol; 2009 Nov; 29(21):5872-88. PubMed ID: 19703994
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Targeting the vulnerability to NAD
    Takao S; Chien W; Madan V; Lin DC; Ding LW; Sun QY; Mayakonda A; Sudo M; Xu L; Chen Y; Jiang YY; Gery S; Lill M; Park E; Senapedis W; Baloglu E; Müschen M; Koeffler HP
    Leukemia; 2018 Mar; 32(3):616-625. PubMed ID: 28904384
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Hyperthermophilic Archaeon Thermococcus kodakarensis Utilizes a Four-Step Pathway for NAD
    Hachisuka SI; Sato T; Atomi H
    J Bacteriol; 2018 Jun; 200(11):. PubMed ID: 29555696
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Nicotinamide phosphoribosyl transferase (Nampt) is required for de novo lipogenesis in tumor cells.
    Bowlby SC; Thomas MJ; D'Agostino RB; Kridel SJ
    PLoS One; 2012; 7(6):e40195. PubMed ID: 22768255
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.