512 related articles for article (PubMed ID: 24204323)
1. Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approaches.
Pinto RM; Dragileva E; Kirby A; Lloret A; Lopez E; St Claire J; Panigrahi GB; Hou C; Holloway K; Gillis T; Guide JR; Cohen PE; Li GM; Pearson CE; Daly MJ; Wheeler VC
PLoS Genet; 2013 Oct; 9(10):e1003930. PubMed ID: 24204323
[TBL] [Abstract][Full Text] [Related]
2. Therapeutic validation of MMR-associated genetic modifiers in a human ex vivo model of Huntington disease.
Ferguson R; Goold R; Coupland L; Flower M; Tabrizi SJ
Am J Hum Genet; 2024 Jun; 111(6):1165-1183. PubMed ID: 38749429
[TBL] [Abstract][Full Text] [Related]
3. A CAG repeat threshold for therapeutics targeting somatic instability in Huntington's disease.
Aldous SG; Smith EJ; Landles C; Osborne GF; Cañibano-Pico M; Nita IM; Phillips J; Zhang Y; Jin B; Hirst MB; Benn CL; Bond BC; Edelmann W; Greene JR; Bates GP
Brain; 2024 May; 147(5):1784-1798. PubMed ID: 38387080
[TBL] [Abstract][Full Text] [Related]
4. Msh2 acts in medium-spiny striatal neurons as an enhancer of CAG instability and mutant huntingtin phenotypes in Huntington's disease knock-in mice.
Kovalenko M; Dragileva E; St Claire J; Gillis T; Guide JR; New J; Dong H; Kucherlapati R; Kucherlapati MH; Ehrlich ME; Lee JM; Wheeler VC
PLoS One; 2012; 7(9):e44273. PubMed ID: 22970194
[TBL] [Abstract][Full Text] [Related]
5. MSH3 polymorphisms and protein levels affect CAG repeat instability in Huntington's disease mice.
Tomé S; Manley K; Simard JP; Clark GW; Slean MM; Swami M; Shelbourne PF; Tillier ER; Monckton DG; Messer A; Pearson CE
PLoS Genet; 2013; 9(2):e1003280. PubMed ID: 23468640
[TBL] [Abstract][Full Text] [Related]
6. Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington's disease knock-in mice is blocked by Mlh1 knock-out.
Loupe JM; Pinto RM; Kim KH; Gillis T; Mysore JS; Andrew MA; Kovalenko M; Murtha R; Seong I; Gusella JF; Kwak S; Howland D; Lee R; Lee JM; Wheeler VC; MacDonald ME
Hum Mol Genet; 2020 Nov; 29(18):3044-3053. PubMed ID: 32876667
[TBL] [Abstract][Full Text] [Related]
7. Disease-associated repeat instability and mismatch repair.
Schmidt MHM; Pearson CE
DNA Repair (Amst); 2016 Feb; 38():117-126. PubMed ID: 26774442
[TBL] [Abstract][Full Text] [Related]
8. Genetic background modifies nuclear mutant huntingtin accumulation and HD CAG repeat instability in Huntington's disease knock-in mice.
Lloret A; Dragileva E; Teed A; Espinola J; Fossale E; Gillis T; Lopez E; Myers RH; MacDonald ME; Wheeler VC
Hum Mol Genet; 2006 Jun; 15(12):2015-24. PubMed ID: 16687439
[TBL] [Abstract][Full Text] [Related]
9. FAN1 controls mismatch repair complex assembly via MLH1 retention to stabilize CAG repeat expansion in Huntington's disease.
Goold R; Hamilton J; Menneteau T; Flower M; Bunting EL; Aldous SG; Porro A; Vicente JR; Allen ND; Wilkinson H; Bates GP; Sartori AA; Thalassinos K; Balmus G; Tabrizi SJ
Cell Rep; 2021 Aug; 36(9):109649. PubMed ID: 34469738
[TBL] [Abstract][Full Text] [Related]
10. Somatic CAG expansion in Huntington's disease is dependent on the MLH3 endonuclease domain, which can be excluded via splice redirection.
Roy JCL; Vitalo A; Andrew MA; Mota-Silva E; Kovalenko M; Burch Z; Nhu AM; Cohen PE; Grabczyk E; Wheeler VC; Mouro Pinto R
Nucleic Acids Res; 2021 Apr; 49(7):3907-3918. PubMed ID: 33751106
[TBL] [Abstract][Full Text] [Related]
11. Dose-dependent reduction of somatic expansions but not Htt aggregates by di-valent siRNA-mediated silencing of MSH3 in HdhQ111 mice.
Driscoll R; Hampton L; Abraham NA; Larigan JD; Joseph NF; Hernandez-Vega JC; Geisler S; Yang FC; Deninger M; Tran DT; Khatri N; Godinho BMDC; Kinberger GA; Montagna DR; Hirst WD; Guardado CL; Glajch KE; Arnold HM; Gallant-Behm CL; Weihofen A
Sci Rep; 2024 Jan; 14(1):2061. PubMed ID: 38267530
[TBL] [Abstract][Full Text] [Related]
12. MutLγ promotes repeat expansion in a Fragile X mouse model while EXO1 is protective.
Zhao X; Zhang Y; Wilkins K; Edelmann W; Usdin K
PLoS Genet; 2018 Oct; 14(10):e1007719. PubMed ID: 30312299
[TBL] [Abstract][Full Text] [Related]
13. Chromosome substitution strain assessment of a Huntington's disease modifier locus.
Ramos EM; Kovalenko M; Guide JR; St Claire J; Gillis T; Mysore JS; Sequeiros J; Wheeler VC; Alonso I; MacDonald ME
Mamm Genome; 2015 Apr; 26(3-4):119-30. PubMed ID: 25645993
[TBL] [Abstract][Full Text] [Related]
14. Mismatch repair gene Msh2 modifies the timing of early disease in Hdh(Q111) striatum.
Wheeler VC; Lebel LA; Vrbanac V; Teed A; te Riele H; MacDonald ME
Hum Mol Genet; 2003 Feb; 12(3):273-81. PubMed ID: 12554681
[TBL] [Abstract][Full Text] [Related]
15. Diverse effects of individual mismatch repair components on transcription-induced CAG repeat instability in human cells.
Lin Y; Wilson JH
DNA Repair (Amst); 2009 Aug; 8(8):878-85. PubMed ID: 19497791
[TBL] [Abstract][Full Text] [Related]
16. Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse.
Chen PC; Dudley S; Hagen W; Dizon D; Paxton L; Reichow D; Yoon SR; Yang K; Arnheim N; Liskay RM; Lipkin SM
Cancer Res; 2005 Oct; 65(19):8662-70. PubMed ID: 16204034
[TBL] [Abstract][Full Text] [Related]
17. MutLα heterodimers modify the molecular phenotype of Friedreich ataxia.
Ezzatizadeh V; Sandi C; Sandi M; Anjomani-Virmouni S; Al-Mahdawi S; Pook MA
PLoS One; 2014; 9(6):e100523. PubMed ID: 24971578
[TBL] [Abstract][Full Text] [Related]
18. Loss of TDP-43 promotes somatic CAG repeat expansion in Huntington's disease knock-in mice.
Bai D; Zhu L; Jia Q; Duan X; Chen L; Wang X; Hou J; Jiang G; Yang S; Li S; Li XJ; Yin P
Prog Neurobiol; 2023 Aug; 227():102484. PubMed ID: 37315918
[TBL] [Abstract][Full Text] [Related]
19. Modifiers of Somatic Repeat Instability in Mouse Models of Friedreich Ataxia and the Fragile X-Related Disorders: Implications for the Mechanism of Somatic Expansion in Huntington's Disease.
Zhao X; Kumari D; Miller CJ; Kim GY; Hayward B; Vitalo AG; Pinto RM; Usdin K
J Huntingtons Dis; 2021; 10(1):149-163. PubMed ID: 33579860
[TBL] [Abstract][Full Text] [Related]
20. Human MutLγ, the MLH1-MLH3 heterodimer, is an endonuclease that promotes DNA expansion.
Kadyrova LY; Gujar V; Burdett V; Modrich PL; Kadyrov FA
Proc Natl Acad Sci U S A; 2020 Feb; 117(7):3535-3542. PubMed ID: 32015124
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
