BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

253 related articles for article (PubMed ID: 24226772)

  • 1. Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors.
    Lloyd DJ; St Jean DJ; Kurzeja RJ; Wahl RC; Michelsen K; Cupples R; Chen M; Wu J; Sivits G; Helmering J; Komorowski R; Ashton KS; Pennington LD; Fotsch C; Vazir M; Chen K; Chmait S; Zhang J; Liu L; Norman MH; Andrews KL; Bartberger MD; Van G; Galbreath EJ; Vonderfecht SL; Wang M; Jordan SR; Véniant MM; Hale C
    Nature; 2013 Dec; 504(7480):437-40. PubMed ID: 24226772
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Recent Updates on Glucokinase Activators and Glucokinase Regulatory Protein Disrupters for the Treatment of Type 2 Diabetes Mellitus.
    Kaushik A; Kaushik M
    Curr Diabetes Rev; 2019; 15(3):205-212. PubMed ID: 30039763
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series.
    Nishimura N; Norman MH; Liu L; Yang KC; Ashton KS; Bartberger MD; Chmait S; Chen J; Cupples R; Fotsch C; Helmering J; Jordan SR; Kunz RK; Pennington LD; Poon SF; Siegmund A; Sivits G; Lloyd DJ; Hale C; St Jean DJ
    J Med Chem; 2014 Apr; 57(7):3094-116. PubMed ID: 24611879
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 1. Discovery of a novel tool compound for in vivo proof-of-concept.
    Ashton KS; Andrews KL; Bryan MC; Chen J; Chen K; Chen M; Chmait S; Croghan M; Cupples R; Fotsch C; Helmering J; Jordan SR; Kurzeja RJ; Michelsen K; Pennington LD; Poon SF; Sivits G; Van G; Vonderfecht SL; Wahl RC; Zhang J; Lloyd DJ; Hale C; St Jean DJ
    J Med Chem; 2014 Jan; 57(2):309-24. PubMed ID: 24405172
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase-Glucokinase Regulatory Protein (GK-GKRP) Binding: Strategic Use of a N → S (nN → σ*S-X) Interaction for Conformational Constraint.
    Pennington LD; Bartberger MD; Croghan MD; Andrews KL; Ashton KS; Bourbeau MP; Chen J; Chmait S; Cupples R; Fotsch C; Helmering J; Hong FT; Hungate RW; Jordan SR; Kong K; Liu L; Michelsen K; Moyer C; Nishimura N; Norman MH; Reichelt A; Siegmund AC; Sivits G; Tadesse S; Tegley CM; Van G; Yang KC; Yao G; Zhang J; Lloyd DJ; Hale C; St Jean DJ
    J Med Chem; 2015 Dec; 58(24):9663-79. PubMed ID: 26551034
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis.
    Tamayo NA; Norman MH; Bartberger MD; Hong FT; Bo Y; Liu L; Nishimura N; Yang KC; Tadesse S; Fotsch C; Chen J; Chmait S; Cupples R; Hale C; Jordan SR; Lloyd DJ; Sivits G; Van G; St Jean DJ
    J Med Chem; 2015 Jun; 58(11):4462-82. PubMed ID: 25914941
    [TBL] [Abstract][Full Text] [Related]  

  • 7. [Glucokinase and glucokinase regulatory proteins as molecular targets for novel antidiabetic drugs].
    Rubtsov PM; Igudin EL; Tiulpakov AN
    Mol Biol (Mosk); 2015; 49(4):555-60. PubMed ID: 26299854
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Stimulation of hepatocyte glucose metabolism by novel small molecule glucokinase activators.
    Brocklehurst KJ; Payne VA; Davies RA; Carroll D; Vertigan HL; Wightman HJ; Aiston S; Waddell ID; Leighton B; Coghlan MP; Agius L
    Diabetes; 2004 Mar; 53(3):535-41. PubMed ID: 14988235
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Discovery of Small-Molecule Glucokinase Regulatory Protein Modulators That Restore Glucokinase Activity.
    Chen K; Michelsen K; Kurzeja RJ; Han J; Vazir M; St Jean DJ; Hale C; Wahl RC
    J Biomol Screen; 2014 Aug; 19(7):1014-23. PubMed ID: 24717911
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Molecular basis for the role of glucokinase regulatory protein as the allosteric switch for glucokinase.
    Choi JM; Seo MH; Kyeong HH; Kim E; Kim HS
    Proc Natl Acad Sci U S A; 2013 Jun; 110(25):10171-6. PubMed ID: 23733961
    [TBL] [Abstract][Full Text] [Related]  

  • 11. An allosteric activator of glucokinase impairs the interaction of glucokinase and glucokinase regulatory protein and regulates glucose metabolism.
    Futamura M; Hosaka H; Kadotani A; Shimazaki H; Sasaki K; Ohyama S; Nishimura T; Eiki J; Nagata Y
    J Biol Chem; 2006 Dec; 281(49):37668-74. PubMed ID: 17028192
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles.
    St Jean DJ; Ashton KS; Bartberger MD; Chen J; Chmait S; Cupples R; Galbreath E; Helmering J; Hong FT; Jordan SR; Liu L; Kunz RK; Michelsen K; Nishimura N; Pennington LD; Poon SF; Reid D; Sivits G; Stec MM; Tadesse S; Tamayo N; Van G; Yang KC; Zhang J; Norman MH; Fotsch C; Lloyd DJ; Hale C
    J Med Chem; 2014 Jan; 57(2):325-38. PubMed ID: 24405213
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Treatment of type 2 diabetes by adenoviral-mediated overexpression of the glucokinase regulatory protein.
    Slosberg ED; Desai UJ; Fanelli B; St Denny I; Connelly S; Kaleko M; Boettcher BR; Caplan SL
    Diabetes; 2001 Aug; 50(8):1813-20. PubMed ID: 11473043
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Mice mutant for glucokinase regulatory protein exhibit decreased liver glucokinase: a sequestration mechanism in metabolic regulation.
    Farrelly D; Brown KS; Tieman A; Ren J; Lira SA; Hagan D; Gregg R; Mookhtiar KA; Hariharan N
    Proc Natl Acad Sci U S A; 1999 Dec; 96(25):14511-6. PubMed ID: 10588736
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Berberine alleviates hyperglycemia by targeting hepatic glucokinase in diabetic db/db mice.
    Li M; Dang Y; Li Q; Zhou W; Zuo J; Yao Z; Zhang L; Ji G
    Sci Rep; 2019 May; 9(1):8003. PubMed ID: 31142783
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Allosteric activators of glucokinase: potential role in diabetes therapy.
    Grimsby J; Sarabu R; Corbett WL; Haynes NE; Bizzarro FT; Coffey JW; Guertin KR; Hilliard DW; Kester RF; Mahaney PE; Marcus L; Qi L; Spence CL; Tengi J; Magnuson MA; Chu CA; Dvorozniak MT; Matschinsky FM; Grippo JF
    Science; 2003 Jul; 301(5631):370-3. PubMed ID: 12869762
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Acetylation of glucokinase regulatory protein decreases glucose metabolism by suppressing glucokinase activity.
    Park JM; Kim TH; Jo SH; Kim MY; Ahn YH
    Sci Rep; 2015 Dec; 5():17395. PubMed ID: 26620281
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Glucokinase regulatory protein is essential for the proper subcellular localisation of liver glucokinase.
    de la Iglesia N; Veiga-da-Cunha M; Van Schaftingen E; Guinovart JJ; Ferrer JC
    FEBS Lett; 1999 Aug; 456(2):332-8. PubMed ID: 10456334
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A patent review of glucokinase activators and disruptors of the glucokinase--glucokinase regulatory protein interaction: 2011-2014.
    Filipski KJ; Pfefferkorn JA
    Expert Opin Ther Pat; 2014 Aug; 24(8):875-91. PubMed ID: 24821087
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Glucotoxicity targets hepatic glucokinase in Zucker diabetic fatty rats, a model of type 2 diabetes associated with obesity.
    Ueta K; O'Brien TP; McCoy GA; Kim K; Healey EC; Farmer TD; Donahue EP; Condren AB; Printz RL; Shiota M
    Am J Physiol Endocrinol Metab; 2014 Jun; 306(11):E1225-38. PubMed ID: 24714398
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.