140 related articles for article (PubMed ID: 24251719)
1. An overview of patented small molecule stearoyl coenzyme-A desaturase inhibitors (2009 - 2013).
Powell DA
Expert Opin Ther Pat; 2014 Feb; 24(2):155-75. PubMed ID: 24251719
[TBL] [Abstract][Full Text] [Related]
2. Stearoyl-CoA desaturase inhibitors: update on patented compounds.
Liu G
Expert Opin Ther Pat; 2009 Sep; 19(9):1169-91. PubMed ID: 19691439
[TBL] [Abstract][Full Text] [Related]
3. Novel substituted heteroaromatic compounds as inhibitors of stearoyl-CoA desaturase.
Dobrzyn P; Dobrzyn A
Expert Opin Ther Pat; 2010 Jun; 20(6):849-53. PubMed ID: 20205608
[TBL] [Abstract][Full Text] [Related]
4. Discovery of potent and liver-targeted stearoyl-CoA desaturase (SCD) inhibitors in a bispyrrolidine series.
Lachance N; Gareau Y; Guiral S; Huang Z; Isabel E; Leclerc JP; Léger S; Martins E; Nadeau C; Oballa RM; Ouellet SG; Powell DA; Ramtohul YK; Tranmer GK; Trinh T; Wang H; Zhang L
Bioorg Med Chem Lett; 2012 Jan; 22(2):980-4. PubMed ID: 22209206
[TBL] [Abstract][Full Text] [Related]
5. Development of a high-throughput screening assay for stearoyl-CoA desaturase using rat liver microsomes, deuterium labeled stearoyl-CoA and mass spectrometry.
Soulard P; McLaughlin M; Stevens J; Connolly B; Coli R; Wang L; Moore J; Kuo MS; LaMarr WA; Ozbal CC; Bhat BG
Anal Chim Acta; 2008 Oct; 627(1):105-11. PubMed ID: 18790133
[TBL] [Abstract][Full Text] [Related]
6. Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia.
Oballa RM; Belair L; Black WC; Bleasby K; Chan CC; Desroches C; Du X; Gordon R; Guay J; Guiral S; Hafey MJ; Hamelin E; Huang Z; Kennedy B; Lachance N; Landry F; Li CS; Mancini J; Normandin D; Pocai A; Powell DA; Ramtohul YK; Skorey K; Sørensen D; Sturkenboom W; Styhler A; Waddleton DM; Wang H; Wong S; Xu L; Zhang L
J Med Chem; 2011 Jul; 54(14):5082-96. PubMed ID: 21661758
[TBL] [Abstract][Full Text] [Related]
7. Opportunities and challenges in developing stearoyl-coenzyme A desaturase-1 inhibitors as novel therapeutics for human disease.
Zhang Z; Dales NA; Winther MD
J Med Chem; 2014 Jun; 57(12):5039-56. PubMed ID: 24295027
[TBL] [Abstract][Full Text] [Related]
8. Discovery of potent and liver-selective stearoyl-CoA desaturase (SCD) inhibitors in an acyclic linker series.
Lachance N; Guiral S; Huang Z; Leclerc JP; Li CS; Oballa RM; Ramtohul YK; Wang H; Wu J; Zhang L
Bioorg Med Chem Lett; 2012 Jan; 22(1):623-7. PubMed ID: 22101133
[TBL] [Abstract][Full Text] [Related]
9. Conversion of systemically-distributed triazole-based stearoyl-CoA desaturase (SCD) uHTS hits into liver-targeted SCD inhibitors.
Leclerc JP; Falgueyret JP; Girardin M; Guay J; Guiral S; Huang Z; Li CS; Oballa R; Ramtohul YK; Skorey K; Tawa P; Wang H; Zhang L
Bioorg Med Chem Lett; 2011 Nov; 21(21):6505-9. PubMed ID: 21924609
[TBL] [Abstract][Full Text] [Related]
10. 2-Aryl benzimidazoles: human SCD1-specific stearoyl coenzyme-A desaturase inhibitors.
Powell DA; Ramtohul Y; Lebrun ME; Oballa R; Bhat S; Falgueyret JP; Guiral S; Huang Z; Skorey K; Tawa P; Zhang L
Bioorg Med Chem Lett; 2010 Nov; 20(22):6366-9. PubMed ID: 20933412
[TBL] [Abstract][Full Text] [Related]
11. Recent progress in the discovery and development of stearoyl CoA desaturase inhibitors.
Uto Y
Chem Phys Lipids; 2016 May; 197():3-12. PubMed ID: 26344107
[TBL] [Abstract][Full Text] [Related]
12. Biological activity and preclinical efficacy of azetidinyl pyridazines as potent systemically-distributed stearoyl-CoA desaturase inhibitors.
Isabel E; Powell DA; Black WC; Chan CC; Crane S; Gordon R; Guay J; Guiral S; Huang Z; Robichaud J; Skorey K; Tawa P; Xu L; Zhang L; Oballa R
Bioorg Med Chem Lett; 2011 Jan; 21(1):479-83. PubMed ID: 21074991
[TBL] [Abstract][Full Text] [Related]
13. Nicotinic acids: liver-targeted SCD inhibitors with preclinical anti-diabetic efficacy.
Powell DA; Black WC; Bleasby K; Chan CC; Deschenes D; Gagnon M; Gordon R; Guay J; Guiral S; Hafey MJ; Huang Z; Isabel E; Leblanc Y; Styhler A; Xu LJ; Zhang L; Oballa RM
Bioorg Med Chem Lett; 2011 Dec; 21(24):7281-6. PubMed ID: 22047692
[TBL] [Abstract][Full Text] [Related]
14. SAR and optimization of thiazole analogs as potent stearoyl-CoA desaturase inhibitors.
Ramtohul YK; Black C; Chan CC; Crane S; Guay J; Guiral S; Huang Z; Oballa R; Xu LJ; Zhang L; Li CS
Bioorg Med Chem Lett; 2010 Mar; 20(5):1593-7. PubMed ID: 20137926
[TBL] [Abstract][Full Text] [Related]
15. Discovery of Cytochrome P450 4F11 Activated Inhibitors of Stearoyl Coenzyme A Desaturase.
Winterton SE; Capota E; Wang X; Chen H; Mallipeddi PL; Williams NS; Posner BA; Nijhawan D; Ready JM
J Med Chem; 2018 Jun; 61(12):5199-5221. PubMed ID: 29869888
[TBL] [Abstract][Full Text] [Related]
16. Protein engineering: Regulatory perspectives of stearoyl CoA desaturase.
Kamal S; Saleem A; Rehman S; Bibi I; Iqbal HMN
Int J Biol Macromol; 2018 Jul; 114():692-699. PubMed ID: 29605251
[TBL] [Abstract][Full Text] [Related]
17. Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438).
Léger S; Black WC; Deschenes D; Dolman S; Falgueyret JP; Gagnon M; Guiral S; Huang Z; Guay J; Leblanc Y; Li CS; Massé F; Oballa R; Zhang L
Bioorg Med Chem Lett; 2010 Jan; 20(2):499-502. PubMed ID: 20004097
[TBL] [Abstract][Full Text] [Related]
18. Pharmacological inhibition of stearoyl-CoA desaturase 1 improves insulin sensitivity in insulin-resistant rat models.
Issandou M; Bouillot A; Brusq JM; Forest MC; Grillot D; Guillard R; Martin S; Michiels C; Sulpice T; Daugan A
Eur J Pharmacol; 2009 Sep; 618(1-3):28-36. PubMed ID: 19616540
[TBL] [Abstract][Full Text] [Related]
19. Azacycloalkane derivatives as inhibitors of delta-9 stearoyl-coenzyme A desaturase.
Liu G
Expert Opin Ther Pat; 2009 Jun; 19(6):885-91. PubMed ID: 19473107
[TBL] [Abstract][Full Text] [Related]
20. Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors.
Koltun DO; Parkhill EQ; Vasilevich NI; Glushkov AI; Zilbershtein TM; Ivanov AV; Cole AG; Henderson I; Zautke NA; Brunn SA; Mollova N; Leung K; Chisholm JW; Zablocki J
Bioorg Med Chem Lett; 2009 Apr; 19(7):2048-52. PubMed ID: 19249203
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
