99 related articles for article (PubMed ID: 2426568)
21. Importance of pharmacodynamics in the in vitro antiproliferative activity of the antifolates methotrexate and 10-ethyl-10-deazaaminopterin against human head and neck squamous cell carcinoma.
Braakhuis BJ; Jansen G; Noordhuis P; Kegel A; Peters GJ
Biochem Pharmacol; 1993 Dec; 46(12):2155-61. PubMed ID: 7506025
[TBL] [Abstract][Full Text] [Related]
22. Experimental therapeutics with a new 10-deazaaminopterin in human mesothelioma: further improving efficacy through structural design, pharmacologic modulation at the level of MRP ATPases, and combined therapy with platinums.
Khokhar NZ; She Y; Rusch VW; Sirotnak FM
Clin Cancer Res; 2001 Oct; 7(10):3199-205. PubMed ID: 11595715
[TBL] [Abstract][Full Text] [Related]
23. Formation of methotrexate polyglutamates in purified myeloid precursor cells from normal human bone marrow.
Koizumi S; Curt GA; Fine RL; Griffin JD; Chabner BA
J Clin Invest; 1985 Mar; 75(3):1008-14. PubMed ID: 2579975
[TBL] [Abstract][Full Text] [Related]
24. Polyglutamylation of the dihydrofolate reductase inhibitor gamma-methylene-10-deazaaminopterin is not essential for antitumor activity.
Cao S; Abraham A; Nair MG; Pati R; Galivan JH; Hausheer FH; Rustum YM
Clin Cancer Res; 1996 Apr; 2(4):707-12. PubMed ID: 9816221
[TBL] [Abstract][Full Text] [Related]
25. Inhibition of glycinamide ribonucleotide formyltransferase and other folate enzymes by homofolate polyglutamates in human lymphoma and murine leukemia cell extracts.
Thorndike J; Gaumont Y; Kisliuk RL; Sirotnak FM; Murthy BR; Nair MG; Piper JR
Cancer Res; 1989 Jan; 49(1):158-63. PubMed ID: 2521177
[TBL] [Abstract][Full Text] [Related]
26. New folate analogs of the 10-deaza-aminopterin series. Basis for structural design and biochemical and pharmacologic properties.
Sirotnak FM; DeGraw JI; Moccio DM; Samuels LL; Goutas LJ
Cancer Chemother Pharmacol; 1984; 12(1):18-25. PubMed ID: 6690069
[TBL] [Abstract][Full Text] [Related]
27. Proliferation-dependent cytotoxicity of methotrexate in murine L5178Y leukemia.
Fernandes DJ; Sur P; Kute TE; Capizzi RL
Cancer Res; 1988 Oct; 48(20):5638-44. PubMed ID: 2458828
[TBL] [Abstract][Full Text] [Related]
28. The role of methotrexate and dihydrofolate polyglutamates in the enhancement of fluorouracil action by methotrexate.
Fernandes DJ; Moroson BA; Bertino JR
Cancer Treat Rep; 1981; 65 Suppl 1():29-35. PubMed ID: 6173121
[TBL] [Abstract][Full Text] [Related]
29. Ex vivo activity of methotrexate versus novel antifolate inhibitors of dihydrofolate reductase and thymidylate synthase against childhood leukemia cells.
Mauritz R; Bekkenk MW; Rots MG; Pieters R; Mini E; van Zantwijk CH; Veerman AJ; Peters GJ; Jansen G
Clin Cancer Res; 1998 Oct; 4(10):2399-410. PubMed ID: 9796971
[TBL] [Abstract][Full Text] [Related]
30. Methotrexate analogues. 29. Effect of gamma-aminobutyric acid spacers between the pteroyl and glutamate moieties on enzyme binding and cell growth inhibition.
Rosowsky A; Forsch RA; Freisheim JH; Danenberg PV; Moran RG; Wick MM
J Med Chem; 1986 Oct; 29(10):1872-6. PubMed ID: 2428979
[TBL] [Abstract][Full Text] [Related]
31. Inhibition of human dihydrofolate reductase by antifolyl polyglutamates.
Kumar P; Kisliuk RL; Gaumont Y; Freisheim JH; Nair MG
Biochem Pharmacol; 1989 Feb; 38(3):541-3. PubMed ID: 2465007
[No Abstract] [Full Text] [Related]
32. Cellular pharmacology and in vivo activity of a new anticancer agent, ZD9331: a water-soluble, nonpolyglutamatable, quinazoline-based inhibitor of thymidylate synthase.
Jackman AL; Kimbell R; Aherne GW; Brunton L; Jansen G; Stephens TC; Smith MN; Wardleworth JM; Boyle FT
Clin Cancer Res; 1997 Jun; 3(6):911-21. PubMed ID: 9815766
[TBL] [Abstract][Full Text] [Related]
33. Synergistic growth inhibition of rat hepatoma cells exposed in vitro to N10-propargyl-5,8-dideazafolate with methotrexate or the lipophilic antifolates trimetrexate or metoprine.
Galivan J; Nimec Z; Rhee M
Cancer Res; 1987 Oct; 47(20):5256-60. PubMed ID: 2958130
[TBL] [Abstract][Full Text] [Related]
34. Antifolates in rheumatoid arthritis: a hypothetical mechanism of action.
Baggott JE; Morgan SL; Ha TS; Alarcón GS; Koopman WJ; Krumdieck CL
Clin Exp Rheumatol; 1993; 11 Suppl 8():S101-5. PubMed ID: 8324932
[TBL] [Abstract][Full Text] [Related]
35. Formation of 7-hydroxymethotrexate polyglutamyl derivatives and their cytotoxicity in human chronic myelogenous leukemia cells, in vitro.
Fabre G; Goldman ID
Cancer Res; 1985 Jan; 45(1):80-5. PubMed ID: 2578101
[TBL] [Abstract][Full Text] [Related]
36. Inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase, adenosine deaminase and 5'-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide.
Baggott JE; Vaughn WH; Hudson BB
Biochem J; 1986 May; 236(1):193-200. PubMed ID: 2431676
[TBL] [Abstract][Full Text] [Related]
37. Quinazoline thymidylate synthase inhibitors: methods for assessing the contribution of polyglutamation to their in vitro activity.
Jackman AL; Kimbell R; Brown M; Brunton L; Boyle FT
Anticancer Drug Des; 1995 Oct; 10(7):555-72. PubMed ID: 7495479
[TBL] [Abstract][Full Text] [Related]
38. Cytotoxicity, uptake, polyglutamate formation, and antileukemic effects of 8-deaza analogues of methotrexate and aminopterin in mice.
Kuehl M; Brixner DI; Broom AD; Avery TL; Blakley RL
Cancer Res; 1988 Mar; 48(6):1481-8. PubMed ID: 2449950
[TBL] [Abstract][Full Text] [Related]
39. Activity of the new antifolate N10-propargyl-5,8-dideazafolate and its polyglutamates against human dihydrofolate reductase, human thymidylate synthetase, and KB cells containing different levels of dihydrofolate reductase.
Cheng YC; Dutschman GE; Starnes MC; Fisher MH; Nanavathi NT; Nair MG
Cancer Res; 1985 Feb; 45(2):598-600. PubMed ID: 3917852
[TBL] [Abstract][Full Text] [Related]
40. Synthesis and biologic activity of new side-chain-altered methotrexate and aminopterin analogs with dual inhibitory action against dihydrofolate reductase and folylpolyglutamate synthetase.
Rosowsky A; Moran RG; Freisheim JH; Bader H; Forsch RA; Solan VC
NCI Monogr; 1987; (5):145-52. PubMed ID: 3431589
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]