682 related articles for article (PubMed ID: 24277854)
1. Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974.
Liu J; Pan S; Hsieh MH; Ng N; Sun F; Wang T; Kasibhatla S; Schuller AG; Li AG; Cheng D; Li J; Tompkins C; Pferdekamper A; Steffy A; Cheng J; Kowal C; Phung V; Guo G; Wang Y; Graham MP; Flynn S; Brenner JC; Li C; Villarroel MC; Schultz PG; Wu X; McNamara P; Sellers WR; Petruzzelli L; Boral AL; Seidel HM; McLaughlin ME; Che J; Carey TE; Vanasse G; Harris JL
Proc Natl Acad Sci U S A; 2013 Dec; 110(50):20224-9. PubMed ID: 24277854
[TBL] [Abstract][Full Text] [Related]
2. Porcupine Inhibitor LGK974 Downregulates the Wnt Signaling Pathway and Inhibits Clear Cell Renal Cell Carcinoma.
Li J; Wu G; Xu Y; Li J; Ruan N; Chen Y; Zhang Q; Xia Q
Biomed Res Int; 2020; 2020():2527643. PubMed ID: 32104684
[TBL] [Abstract][Full Text] [Related]
3. Porcupine inhibitors: Novel and emerging anti-cancer therapeutics targeting the Wnt signaling pathway.
Shah K; Panchal S; Patel B
Pharmacol Res; 2021 May; 167():105532. PubMed ID: 33677106
[TBL] [Abstract][Full Text] [Related]
4. Porcupine inhibitor LGK‑974 inhibits Wnt/β‑catenin signaling and modifies tumor‑associated macrophages resulting in inhibition of the malignant behaviors of non‑small cell lung cancer cells.
Tang Y; Jiang M; Chen A; Qu W; Han X; Zuo J; Xu G; Song Y; Chen C; Ke X
Mol Med Rep; 2021 Aug; 24(2):. PubMed ID: 34080032
[TBL] [Abstract][Full Text] [Related]
5. Mechanisms and inhibition of Porcupine-mediated Wnt acylation.
Liu Y; Qi X; Donnelly L; Elghobashi-Meinhardt N; Long T; Zhou RW; Sun Y; Wang B; Li X
Nature; 2022 Jul; 607(7920):816-822. PubMed ID: 35831507
[TBL] [Abstract][Full Text] [Related]
6. Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer.
Proffitt KD; Madan B; Ke Z; Pendharkar V; Ding L; Lee MA; Hannoush RN; Virshup DM
Cancer Res; 2013 Jan; 73(2):502-7. PubMed ID: 23188502
[TBL] [Abstract][Full Text] [Related]
7. Novel PORCN inhibitor WHN-88 targets Wnt/β-catenin pathway and prevents the growth of Wnt-driven cancers.
Yang Q; Qin T; An T; Wu H; Xu G; Xiang J; Lei K; Zhang S; Xia J; Su G; Wang D; Xue M; Kong L; Zhang W; Wu S; Li Y
Eur J Pharmacol; 2023 Apr; 945():175628. PubMed ID: 36858339
[TBL] [Abstract][Full Text] [Related]
8. LGK974, a PORCUPINE inhibitor, mitigates cytotoxicity in an in vitro model of Parkinson's disease by interfering with the WNT/β-CATENIN pathway.
Yang JM; Huang HM; Cheng JJ; Huang CL; Lee YC; Chiou CT; Huang HT; Huang NK; Yang YC
Toxicology; 2018 Dec; 410():65-72. PubMed ID: 30205152
[TBL] [Abstract][Full Text] [Related]
9. Potent in vivo lung cancer Wnt signaling inhibition via cyclodextrin-LGK974 inclusion complexes.
Guimaraes PPG; Tan M; Tammela T; Wu K; Chung A; Oberli M; Wang K; Spektor R; Riley RS; Viana CTR; Jacks T; Langer R; Mitchell MJ
J Control Release; 2018 Nov; 290():75-87. PubMed ID: 30290244
[TBL] [Abstract][Full Text] [Related]
10. Chemical Modulation of WNT Signaling in Cancer.
Zhang LS; Lum L
Prog Mol Biol Transl Sci; 2018 Jan; 153():245-269. PubMed ID: 29389519
[TBL] [Abstract][Full Text] [Related]
11. An
Asciolla JJ; Miele MM; Hendrickson RC; Resh MD
J Biol Chem; 2017 Aug; 292(33):13507-13513. PubMed ID: 28655768
[TBL] [Abstract][Full Text] [Related]
12. Exploration of the linkage elements of porcupine antagonists led to potent Wnt signaling pathway inhibitors.
Dong Y; Li K; Xu Z; Ma H; Zheng J; Hu Z; He S; Wu Y; Sun Z; Luo L; Li J; Zhang H; Zhang X
Bioorg Med Chem; 2015 Nov; 23(21):6855-68. PubMed ID: 26455655
[TBL] [Abstract][Full Text] [Related]
13. WNT ligands control initiation and progression of human papillomavirus-driven squamous cell carcinoma.
Zimmerli D; Cecconi V; Valenta T; Hausmann G; Cantù C; Restivo G; Hafner J; Basler K; van den Broek M
Oncogene; 2018 Jul; 37(27):3753-3762. PubMed ID: 29662191
[TBL] [Abstract][Full Text] [Related]
14. Targeting of Deregulated Wnt/β-Catenin Signaling by PRI-724 and LGK974 Inhibitors in Germ Cell Tumor Cell Lines.
Schmidtova S; Kalavska K; Liskova V; Plava J; Miklikova S; Kucerova L; Matuskova M; Rojikova L; Cierna Z; Rogozea A; Konig H; Albany C; Mego M; Chovanec M
Int J Mol Sci; 2021 Apr; 22(8):. PubMed ID: 33923996
[TBL] [Abstract][Full Text] [Related]
15. Inhibition of CBP/β-catenin and porcupine attenuates Wnt signaling and induces apoptosis in head and neck carcinoma cells.
Kleszcz R; Szymańska A; Krajka-Kuźniak V; Baer-Dubowska W; Paluszczak J
Cell Oncol (Dordr); 2019 Aug; 42(4):505-520. PubMed ID: 31089983
[TBL] [Abstract][Full Text] [Related]
16. Delivery of the Porcupine Inhibitor WNT974 in Mice.
Zhang LS; Lum L
Methods Mol Biol; 2016; 1481():111-7. PubMed ID: 27590157
[TBL] [Abstract][Full Text] [Related]
17. Wnt family member 4 (WNT4) and WNT3A activate cell-autonomous Wnt signaling independent of porcupine
Rao DM; Shackleford MT; Bordeaux EK; Sottnik JL; Ferguson RL; Yamamoto TM; Wellberg EA; Bitler BG; Sikora MJ
J Biol Chem; 2019 Dec; 294(52):19950-19966. PubMed ID: 31740580
[TBL] [Abstract][Full Text] [Related]
18. Porcupine inhibitors impair trabecular and cortical bone mass and strength in mice.
Funck-Brentano T; Nilsson KH; Brommage R; Henning P; Lerner UH; Koskela A; Tuukkanen J; Cohen-Solal M; Movérare-Skrtic S; Ohlsson C
J Endocrinol; 2018 Jul; 238(1):13-23. PubMed ID: 29720540
[TBL] [Abstract][Full Text] [Related]
19. FZD6 triggers Wnt-signalling driven by WNT10B
Cassaro A; Grillo G; Notaro M; Gliozzo J; Esposito I; Reda G; Trojani A; Valentini G; Di Camillo B; Cairoli R; Beghini A
Hematol Oncol; 2021 Aug; 39(3):364-379. PubMed ID: 33497493
[TBL] [Abstract][Full Text] [Related]
20. Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand-Addicted Pancreatic Cancer.
Aguilera KY; Le T; Riahi R; Lay AR; Hinz S; Saadat EA; Vashisht AA; Wohlschlegel J; Donahue TR; Radu CG; Dawson DW
Mol Cancer Ther; 2022 Jun; 21(6):936-947. PubMed ID: 35313331
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]