119 related articles for article (PubMed ID: 24283214)
1. Inhibiting caspase-6 activation and catalytic activity for neurodegenerative diseases.
Flygare JA; Arkin MR
Curr Top Med Chem; 2014; 14(3):319-25. PubMed ID: 24283214
[TBL] [Abstract][Full Text] [Related]
2. UCSF Small Molecule Discovery Center: innovation, collaboration and chemical biology in the Bay Area.
Arkin MR; Ang KK; Chen S; Davies J; Merron C; Tang Y; Wilson CG; Renslo AR
Comb Chem High Throughput Screen; 2014 May; 17(4):333-42. PubMed ID: 24661212
[TBL] [Abstract][Full Text] [Related]
3. Identification of Allosteric Inhibitors against Active Caspase-6.
Tubeleviciute-Aydin A; Beautrait A; Lynham J; Sharma G; Gorelik A; Deny LJ; Soya N; Lukacs GL; Nagar B; Marinier A; LeBlanc AC
Sci Rep; 2019 Apr; 9(1):5504. PubMed ID: 30940883
[TBL] [Abstract][Full Text] [Related]
4. Lazaroids U83836E and U74389G are potent, time-dependent inhibitors of caspase-1.
Kawarski M; Hagerman TK; Karver CE
Chem Biol Drug Des; 2015 Nov; 86(5):1049-54. PubMed ID: 25871734
[TBL] [Abstract][Full Text] [Related]
5. Small Molecule Active Site Directed Tools for Studying Human Caspases.
Poreba M; Szalek A; Kasperkiewicz P; Rut W; Salvesen GS; Drag M
Chem Rev; 2015 Nov; 115(22):12546-629. PubMed ID: 26551511
[TBL] [Abstract][Full Text] [Related]
6. Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6.
Heise CE; Murray J; Augustyn KE; Bravo B; Chugha P; Cohen F; Giannetti AM; Gibbons P; Hannoush RN; Hearn BR; Jaishankar P; Ly CQ; Shah K; Stanger K; Steffek M; Tang Y; Zhao X; Lewcock JW; Renslo AR; Flygare J; Arkin MR
PLoS One; 2012; 7(12):e50864. PubMed ID: 23227217
[TBL] [Abstract][Full Text] [Related]
7. Bringing RNA into the fold: Small molecules find new targets in RNA to combat disease.
Chakradhar S
Nat Med; 2017 May; 23(5):532-534. PubMed ID: 28475574
[No Abstract] [Full Text] [Related]
8. Identification of Potent Caspase-8 Inhibitors from a Library of Fluorescent Natural Products Screened by an AIEgen-Based Light-Up Probe.
Lin H; Yang WQ; Ye Z; Zhang CJ
Chembiochem; 2019 May; 20(10):1292-1296. PubMed ID: 30648790
[TBL] [Abstract][Full Text] [Related]
9. The potential for caspases in drug discovery.
MacKenzie SH; Schipper JL; Clark AC
Curr Opin Drug Discov Devel; 2010 Sep; 13(5):568-76. PubMed ID: 20812148
[TBL] [Abstract][Full Text] [Related]
10. A label-free LC/MS/MS-based enzymatic activity assay for the detection of genuine caspase inhibitors and SAR development.
Maillard MC; Dominguez C; Gemkow MJ; Krieger F; Park H; Schaertl S; Winkler D; Muñoz-Sanjuán I
J Biomol Screen; 2013 Sep; 18(8):868-78. PubMed ID: 23796689
[TBL] [Abstract][Full Text] [Related]
11. Small-molecule procaspase activators identified using fluorescence polarization.
Vickers CJ; González-Páez GE; Umotoy JC; Cayanan-Garrett C; Brown SJ; Wolan DW
Chembiochem; 2013 Aug; 14(12):1419-22. PubMed ID: 23836614
[TBL] [Abstract][Full Text] [Related]
12. Small-molecule activators of a proenzyme.
Wolan DW; Zorn JA; Gray DC; Wells JA
Science; 2009 Nov; 326(5954):853-8. PubMed ID: 19892984
[TBL] [Abstract][Full Text] [Related]
13. Variation of the aryl substituent on the piperazine ring within the 4-(piperazin-1-yl)-2,6-di(pyrrolidin-1-yl)pyrimidine scaffold unveils potent, non-competitive inhibitors of the inflammatory caspases.
Kent CR; Bryja M; Gustafson HA; Kawarski MY; Lenti G; Pierce EN; Knopp RC; Ceja V; Pati B; Walters DE; Karver CE
Bioorg Med Chem Lett; 2016 Nov; 26(22):5476-5480. PubMed ID: 27777011
[TBL] [Abstract][Full Text] [Related]
14. Tailoring small molecules for an allosteric site on procaspase-6.
Murray J; Giannetti AM; Steffek M; Gibbons P; Hearn BR; Cohen F; Tam C; Pozniak C; Bravo B; Lewcock J; Jaishankar P; Ly CQ; Zhao X; Tang Y; Chugha P; Arkin MR; Flygare J; Renslo AR
ChemMedChem; 2014 Jan; 9(1):73-7, 2. PubMed ID: 24259468
[TBL] [Abstract][Full Text] [Related]
15. Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery.
Erlanson DA; Arndt JW; Cancilla MT; Cao K; Elling RA; English N; Friedman J; Hansen SK; Hession C; Joseph I; Kumaravel G; Lee WC; Lind KE; McDowell RS; Miatkowski K; Nguyen C; Nguyen TB; Park S; Pathan N; Penny DM; Romanowski MJ; Scott D; Silvian L; Simmons RL; Tangonan BT; Yang W; Sun L
Bioorg Med Chem Lett; 2011 May; 21(10):3078-83. PubMed ID: 21459573
[TBL] [Abstract][Full Text] [Related]
16. Dopamine-sensitive adenylyl cyclases in neuronal development: physiopathological and pharmacological implications.
Pavan B; Paganetto G; Dalpiaz A
Drug Discov Today; 2011 Jun; 16(11-12):520-9. PubMed ID: 21477663
[TBL] [Abstract][Full Text] [Related]
17. Neurodegenerative drug discovery: building on the past, looking to the future.
Bolognesi ML
Future Med Chem; 2017 May; 9(8):707-709. PubMed ID: 28504913
[No Abstract] [Full Text] [Related]
18. Chemical biologists rush to San Francisco for the ICBS.
Miller EW
Nat Chem Biol; 2015 Feb; 11(2):91-5. PubMed ID: 25602721
[No Abstract] [Full Text] [Related]
19. The regulatory mechanism of the caspase 6 pro-domain revealed by crystal structure and biochemical assays.
Cao Q; Wang XJ; Li LF; Su XD
Acta Crystallogr D Biol Crystallogr; 2014 Jan; 70(Pt 1):58-67. PubMed ID: 24419379
[TBL] [Abstract][Full Text] [Related]
20. Activation and regulation of caspase-6 and its role in neurodegenerative diseases.
Wang XJ; Cao Q; Zhang Y; Su XD
Annu Rev Pharmacol Toxicol; 2015; 55():553-72. PubMed ID: 25340928
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]