BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

235 related articles for article (PubMed ID: 24376006)

  • 1. Discovery of 5''-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2':5',3''-terpyridine-3'-carboxamide (MK-1064): a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia.
    Roecker AJ; Mercer SP; Schreier JD; Cox CD; Fraley ME; Steen JT; Lemaire W; Bruno JG; Harrell CM; Garson SL; Gotter AL; Fox SV; Stevens J; Tannenbaum PL; Prueksaritanont T; Cabalu TD; Cui D; Stellabott J; Hartman GD; Young SD; Winrow CJ; Renger JJ; Coleman PJ
    ChemMedChem; 2014 Feb; 9(2):311-22. PubMed ID: 24376006
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of MK-3697: a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia.
    Roecker AJ; Reger TS; Mattern MC; Mercer SP; Bergman JM; Schreier JD; Cube RV; Cox CD; Li D; Lemaire W; Bruno JG; Harrell CM; Garson SL; Gotter AL; Fox SV; Stevens J; Tannenbaum PL; Prueksaritanont T; Cabalu TD; Cui D; Stellabott J; Hartman GD; Young SD; Winrow CJ; Renger JJ; Coleman PJ
    Bioorg Med Chem Lett; 2014 Oct; 24(20):4884-90. PubMed ID: 25248679
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting properties.
    Coleman PJ; Schreier JD; Cox CD; Breslin MJ; Whitman DB; Bogusky MJ; McGaughey GB; Bednar RA; Lemaire W; Doran SM; Fox SV; Garson SL; Gotter AL; Harrell CM; Reiss DR; Cabalu TD; Cui D; Prueksaritanont T; Stevens J; Tannenbaum PL; Ball RG; Stellabott J; Young SD; Hartman GD; Winrow CJ; Renger JJ
    ChemMedChem; 2012 Mar; 7(3):415-24, 337. PubMed ID: 22307992
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Orexin in sleep, addiction and more: is the perfect insomnia drug at hand?
    Hoyer D; Jacobson LH
    Neuropeptides; 2013 Dec; 47(6):477-88. PubMed ID: 24215799
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Novel Octahydropyrrolo[3,4-c]pyrroles Are Selective Orexin-2 Antagonists: SAR Leading to a Clinical Candidate.
    Letavic MA; Bonaventure P; Carruthers NI; Dugovic C; Koudriakova T; Lord B; Lovenberg TW; Ly KS; Mani NS; Nepomuceno D; Pippel DJ; Rizzolio M; Shelton JE; Shah CR; Shireman BT; Young LK; Yun S
    J Med Chem; 2015 Jul; 58(14):5620-36. PubMed ID: 26087021
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery of diazepane amide DORAs and 2-SORAs enabled by exploration of isosteric quinazoline replacements.
    Roecker AJ; Mercer SP; Bergman JM; Gilbert KF; Kuduk SD; Harrell CM; Garson SL; Fox SV; Gotter AL; Tannenbaum PL; Prueksaritanont T; Cabalu TD; Cui D; Lemaire W; Winrow CJ; Renger JJ; Coleman PJ
    Bioorg Med Chem Lett; 2015 Nov; 25(21):4992-4999. PubMed ID: 25613676
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Pharmacological characterization of MK-6096 - a dual orexin receptor antagonist for insomnia.
    Winrow CJ; Gotter AL; Cox CD; Tannenbaum PL; Garson SL; Doran SM; Breslin MJ; Schreier JD; Fox SV; Harrell CM; Stevens J; Reiss DR; Cui D; Coleman PJ; Renger JJ
    Neuropharmacology; 2012 Feb; 62(2):978-87. PubMed ID: 22019562
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomnia.
    Cox CD; Breslin MJ; Whitman DB; Schreier JD; McGaughey GB; Bogusky MJ; Roecker AJ; Mercer SP; Bednar RA; Lemaire W; Bruno JG; Reiss DR; Harrell CM; Murphy KL; Garson SL; Doran SM; Prueksaritanont T; Anderson WB; Tang C; Roller S; Cabalu TD; Cui D; Hartman GD; Young SD; Koblan KS; Winrow CJ; Renger JJ; Coleman PJ
    J Med Chem; 2010 Jul; 53(14):5320-32. PubMed ID: 20565075
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Orexin receptor antagonists.
    Christopher JA
    Pharm Pat Anal; 2012 Jul; 1(3):329-46. PubMed ID: 24236845
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Update on emerging drugs for insomnia.
    Sullivan S
    Expert Opin Emerg Drugs; 2012 Sep; 17(3):295-8. PubMed ID: 22920041
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia.
    Bonaventure P; Shelton J; Yun S; Nepomuceno D; Sutton S; Aluisio L; Fraser I; Lord B; Shoblock J; Welty N; Chaplan SR; Aguilar Z; Halter R; Ndifor A; Koudriakova T; Rizzolio M; Letavic M; Carruthers NI; Lovenberg T; Dugovic C
    J Pharmacol Exp Ther; 2015 Sep; 354(3):471-82. PubMed ID: 26177655
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Study of human Orexin-1 and -2 G-protein-coupled receptors with novel and published antagonists by modeling, molecular dynamics simulations, and site-directed mutagenesis.
    Heifetz A; Morris GB; Biggin PC; Barker O; Fryatt T; Bentley J; Hallett D; Manikowski D; Pal S; Reifegerste R; Slack M; Law R
    Biochemistry; 2012 Apr; 51(15):3178-97. PubMed ID: 22448975
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery of 2,5-diarylnicotinamides as selective orexin-2 receptor antagonists (2-SORAs).
    Mercer SP; Roecker AJ; Garson S; Reiss DR; Meacham Harrell C; Murphy KL; Bruno JG; Bednar RA; Lemaire W; Cui D; Cabalu TD; Tang C; Prueksaritanont T; Hartman GD; Young SD; Winrow CJ; Renger JJ; Coleman PJ
    Bioorg Med Chem Lett; 2013 Dec; 23(24):6620-4. PubMed ID: 24215892
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Orexin receptors: pharmacology and therapeutic opportunities.
    Scammell TE; Winrow CJ
    Annu Rev Pharmacol Toxicol; 2011; 51():243-66. PubMed ID: 21034217
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery of Highly Potent Dual Orexin Receptor Antagonists via a Scaffold-Hopping Approach.
    Heidmann B; Gatfield J; Roch C; Treiber A; Tortoioli S; Brotschi C; Williams JT; Bolli MH; Abele S; Sifferlen T; Jenck F; Boss C
    ChemMedChem; 2016 Oct; 11(19):2132-2146. PubMed ID: 27390287
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Discovery and development of orexin receptor antagonists as therapeutics for insomnia.
    Winrow CJ; Renger JJ
    Br J Pharmacol; 2014 Jan; 171(2):283-93. PubMed ID: 23731216
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Identification of a novel series of orexin receptor antagonists with a distinct effect on sleep architecture for the treatment of insomnia.
    Betschart C; Hintermann S; Behnke D; Cotesta S; Fendt M; Gee CE; Jacobson LH; Laue G; Ofner S; Chaudhari V; Badiger S; Pandit C; Wagner J; Hoyer D
    J Med Chem; 2013 Oct; 56(19):7590-607. PubMed ID: 23964859
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Selective orexin receptor antagonists.
    Lebold TP; Bonaventure P; Shireman BT
    Bioorg Med Chem Lett; 2013 Sep; 23(17):4761-9. PubMed ID: 23891187
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Design, synthesis, and structure-activity relationships of a series of novel N-aryl-2-phenylcyclopropanecarboxamide that are potent and orally active orexin receptor antagonists.
    Yoshida Y; Terauchi T; Naoe Y; Kazuta Y; Ozaki F; Beuckmann CT; Nakagawa M; Suzuki M; Kushida I; Takenaka O; Ueno T; Yonaga M
    Bioorg Med Chem; 2014 Nov; 22(21):6071-88. PubMed ID: 25267004
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Drugs for insomnia.
    Zisapel N
    Expert Opin Emerg Drugs; 2012 Sep; 17(3):299-317. PubMed ID: 22681198
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.