176 related articles for article (PubMed ID: 24376769)
1. A large-scale allosteric transition in cytochrome P450 3A4 revealed by luminescence resonance energy transfer (LRET).
Sineva EV; Rumfeldt JA; Halpert JR; Davydov DR
PLoS One; 2013; 8(12):e83898. PubMed ID: 24376769
[TBL] [Abstract][Full Text] [Related]
2. Allosteric mechanisms in cytochrome P450 3A4 studied by high-pressure spectroscopy: pivotal role of substrate-induced changes in the accessibility and degree of hydration of the heme pocket.
Davydov DR; Baas BJ; Sligar SG; Halpert JR
Biochemistry; 2007 Jul; 46(26):7852-64. PubMed ID: 17555301
[TBL] [Abstract][Full Text] [Related]
3. Peripheral ligand-binding site in cytochrome P450 3A4 located with fluorescence resonance energy transfer (FRET).
Davydov DR; Rumfeldt JA; Sineva EV; Fernando H; Davydova NY; Halpert JR
J Biol Chem; 2012 Feb; 287(9):6797-809. PubMed ID: 22194603
[TBL] [Abstract][Full Text] [Related]
4. Mechanism of interactions of alpha-naphthoflavone with cytochrome P450 3A4 explored with an engineered enzyme bearing a fluorescent probe.
Tsalkova TN; Davydova NY; Halpert JR; Davydov DR
Biochemistry; 2007 Jan; 46(1):106-19. PubMed ID: 17198380
[TBL] [Abstract][Full Text] [Related]
5. Conformational Mobility in Cytochrome P450 3A4 Explored by Pressure-Perturbation EPR Spectroscopy.
Davydov DR; Yang Z; Davydova N; Halpert JR; Hubbell WL
Biophys J; 2016 Apr; 110(7):1485-1498. PubMed ID: 27074675
[TBL] [Abstract][Full Text] [Related]
6. Pivotal role of P450-P450 interactions in CYP3A4 allostery: the case of α-naphthoflavone.
Davydov DR; Davydova NY; Sineva EV; Kufareva I; Halpert JR
Biochem J; 2013 Jul; 453(2):219-30. PubMed ID: 23651100
[TBL] [Abstract][Full Text] [Related]
7. Allosteric Activation of Cytochrome P450 3A4 via Progesterone Bioconjugation.
Polic V; Auclair K
Bioconjug Chem; 2017 Apr; 28(4):885-889. PubMed ID: 28339191
[TBL] [Abstract][Full Text] [Related]
8. Electron transfer in the complex of membrane-bound human cytochrome P450 3A4 with the flavin domain of P450BM-3: the effect of oligomerization of the heme protein and intermittent modulation of the spin equilibrium.
Davydov DR; Sineva EV; Sistla S; Davydova NY; Frank DJ; Sligar SG; Halpert JR
Biochim Biophys Acta; 2010 Mar; 1797(3):378-90. PubMed ID: 20026040
[TBL] [Abstract][Full Text] [Related]
9. Allosteric effects on substrate dissociation from cytochrome P450 3A4 in nanodiscs observed by ensemble and single-molecule fluorescence spectroscopy.
Nath A; Koo PK; Rhoades E; Atkins WM
J Am Chem Soc; 2008 Nov; 130(47):15746-7. PubMed ID: 18980315
[TBL] [Abstract][Full Text] [Related]
10. Mechanistic Studies of Cytochrome P450 3A4 Time-Dependent Inhibition Using Two Cysteine-Targeting Electrophiles.
Barr JT; Wang Z; Min X; Wienkers HJ; Rock BM; Rock DA; Wienkers LC
Drug Metab Dispos; 2020 Jun; 48(6):508-514. PubMed ID: 32193357
[TBL] [Abstract][Full Text] [Related]
11. Interaction of CYP3A4 with caffeine: First insights into multiple substrate binding.
Sevrioukova IF
J Biol Chem; 2023 Sep; 299(9):105117. PubMed ID: 37524132
[TBL] [Abstract][Full Text] [Related]
12. Resolution of multiple substrate binding sites in cytochrome P450 3A4: the stoichiometry of the enzyme-substrate complexes probed by FRET and Job's titration.
Fernando H; Halpert JR; Davydov DR
Biochemistry; 2006 Apr; 45(13):4199-209. PubMed ID: 16566594
[TBL] [Abstract][Full Text] [Related]
13. Role of cytochrome B5 in modulating peroxide-supported cyp3a4 activity: evidence for a conformational transition and cytochrome P450 heterogeneity.
Kumar S; Davydov DR; Halpert JR
Drug Metab Dispos; 2005 Aug; 33(8):1131-6. PubMed ID: 15870379
[TBL] [Abstract][Full Text] [Related]
14. Improved cytochrome P450 3A4 molecular models accurately predict the Phe215 requirement for raloxifene dehydrogenation selectivity.
Moore CD; Shahrokh K; Sontum SF; Cheatham TE; Yost GS
Biochemistry; 2010 Oct; 49(41):9011-9. PubMed ID: 20812728
[TBL] [Abstract][Full Text] [Related]
15. Molecular Insights into the Heterotropic Allosteric Mechanism in Cytochrome P450 3A4-Mediated Midazolam Metabolism.
Fu T; Zhang H; Zheng Q
J Chem Inf Model; 2022 Nov; 62(22):5762-5770. PubMed ID: 36342224
[TBL] [Abstract][Full Text] [Related]
16. Analysis of heterotropic cooperativity in cytochrome P450 3A4 using alpha-naphthoflavone and testosterone.
Frank DJ; Denisov IG; Sligar SG
J Biol Chem; 2011 Feb; 286(7):5540-5. PubMed ID: 21177853
[TBL] [Abstract][Full Text] [Related]
17. Investigation of the molecular and mechanistic basis for the regioselective metabolism of midazolam by cytochrome P450 3A4.
Fu T; Zheng Q; Zhang H
Phys Chem Chem Phys; 2022 Apr; 24(14):8104-8112. PubMed ID: 35319551
[TBL] [Abstract][Full Text] [Related]
18. The use of isomeric testosterone dimers to explore allosteric effects in substrate binding to cytochrome P450 CYP3A4.
Denisov IG; Mak PJ; Grinkova YV; Bastien D; Bérubé G; Sligar SG; Kincaid JR
J Inorg Biochem; 2016 May; 158():77-85. PubMed ID: 26774838
[TBL] [Abstract][Full Text] [Related]
19. Conformational Response of N-Terminally Truncated Cytochrome P450 3A4 to Ligand Binding in Solution.
Chuo SW; Liou SH; Wang LP; Britt RD; Poulos TL; Sevrioukova IF; Goodin DB
Biochemistry; 2019 Sep; 58(37):3903-3910. PubMed ID: 31456404
[TBL] [Abstract][Full Text] [Related]
20. Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone.
Williams PA; Cosme J; Vinkovic DM; Ward A; Angove HC; Day PJ; Vonrhein C; Tickle IJ; Jhoti H
Science; 2004 Jul; 305(5684):683-6. PubMed ID: 15256616
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
