These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
151 related articles for article (PubMed ID: 24386992)
1. Evaluation of WO2013125543, WO2013146963 and EP2634185: the first Tyk2 inhibitors from Takeda and Sareum. Norman P Expert Opin Ther Pat; 2014 Mar; 24(3):361-8. PubMed ID: 24386992 [TBL] [Abstract][Full Text] [Related]
2. Selective JAK1 inhibitor and selective Tyk2 inhibitor patents. Norman P Expert Opin Ther Pat; 2012 Oct; 22(10):1233-49. PubMed ID: 22971156 [TBL] [Abstract][Full Text] [Related]
3. Evaluation of WO-2013040863, WO-2013041042 and WO-2013043962. Selective JAK1 inhibitors based on a 3-aminopyrazole-4-carboxamide scaffold. Norman P Expert Opin Ther Pat; 2014 Feb; 24(2):231-7. PubMed ID: 24261748 [TBL] [Abstract][Full Text] [Related]
4. Inhibitors of JAK2 and JAK3: an update on the patent literature 2010 - 2012. Dymock BW; See CS Expert Opin Ther Pat; 2013 Apr; 23(4):449-501. PubMed ID: 23367873 [TBL] [Abstract][Full Text] [Related]
5. Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases. Gerstenberger BS; Ambler C; Arnold EP; Banker ME; Brown MF; Clark JD; Dermenci A; Dowty ME; Fensome A; Fish S; Hayward MM; Hegen M; Hollingshead BD; Knafels JD; Lin DW; Lin TH; Owen DR; Saiah E; Sharma R; Vajdos FF; Xing L; Yang X; Yang X; Wright SW J Med Chem; 2020 Nov; 63(22):13561-13577. PubMed ID: 32787094 [TBL] [Abstract][Full Text] [Related]
6. Diamino-1,2,4-triazole derivatives are selective inhibitors of TYK2 and JAK1 over JAK2 and JAK3. Malerich JP; Lam JS; Hart B; Fine RM; Klebansky B; Tanga MJ; D'Andrea A Bioorg Med Chem Lett; 2010 Dec; 20(24):7454-7. PubMed ID: 21106455 [TBL] [Abstract][Full Text] [Related]
7. Design and optimization of a series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1. Fensome A; Ambler CM; Arnold E; Banker ME; Clark JD; Dowty ME; Efremov IV; Flick A; Gerstenberger BS; Gifford RS; Gopalsamy A; Hegen M; Jussif J; Limburg DC; Lin TH; Pierce BS; Sharma R; Trujillo JI; Vajdos FF; Vincent F; Wan ZK; Xing L; Yang X; Yang X Bioorg Med Chem; 2020 May; 28(10):115481. PubMed ID: 32253095 [TBL] [Abstract][Full Text] [Related]
8. Highly selective Janus kinase 3 inhibitors based on a pyrrolo[2,3-d]pyrimidine scaffold: evaluation of WO2013085802. Norman P Expert Opin Ther Pat; 2014 Jan; 24(1):121-5. PubMed ID: 24147573 [TBL] [Abstract][Full Text] [Related]
9. Selective Tyk2 inhibitors as potential therapeutic agents: a patent review (2015-2018). He X; Chen X; Zhang H; Xie T; Ye XY Expert Opin Ther Pat; 2019 Feb; 29(2):137-149. PubMed ID: 30621465 [TBL] [Abstract][Full Text] [Related]
10. Therapeutic potential of tyrosine kinase 2 in autoimmunity. Liang Y; Zhu Y; Xia Y; Peng H; Yang XK; Liu YY; Xu WD; Pan HF; Ye DQ Expert Opin Ther Targets; 2014 May; 18(5):571-80. PubMed ID: 24654603 [TBL] [Abstract][Full Text] [Related]
11. Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050. Fridman JS; Scherle PA; Collins R; Burn TC; Li Y; Li J; Covington MB; Thomas B; Collier P; Favata MF; Wen X; Shi J; McGee R; Haley PJ; Shepard S; Rodgers JD; Yeleswaram S; Hollis G; Newton RC; Metcalf B; Friedman SM; Vaddi K J Immunol; 2010 May; 184(9):5298-307. PubMed ID: 20363976 [TBL] [Abstract][Full Text] [Related]
12. Lead identification of novel and selective TYK2 inhibitors. Liang J; Tsui V; Van Abbema A; Bao L; Barrett K; Beresini M; Berezhkovskiy L; Blair WS; Chang C; Driscoll J; Eigenbrot C; Ghilardi N; Gibbons P; Halladay J; Johnson A; Kohli PB; Lai Y; Liimatta M; Mantik P; Menghrajani K; Murray J; Sambrone A; Xiao Y; Shia S; Shin Y; Smith J; Sohn S; Stanley M; Ultsch M; Zhang B; Wu LC; Magnuson S Eur J Med Chem; 2013 Sep; 67():175-87. PubMed ID: 23867602 [TBL] [Abstract][Full Text] [Related]
13. Selective TYK2 inhibitors as potential therapeutic agents: a patent review (2019-2021). Gonzalez Lopez de Turiso F; Guckian K Expert Opin Ther Pat; 2022 Apr; 32(4):365-379. PubMed ID: 35001782 [TBL] [Abstract][Full Text] [Related]
14. Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model. Liang J; Van Abbema A; Balazs M; Barrett K; Berezhkovsky L; Blair WS; Chang C; Delarosa D; DeVoss J; Driscoll J; Eigenbrot C; Goodacre S; Ghilardi N; MacLeod C; Johnson A; Bir Kohli P; Lai Y; Lin Z; Mantik P; Menghrajani K; Nguyen H; Peng I; Sambrone A; Shia S; Smith J; Sohn S; Tsui V; Ultsch M; Williams K; Wu LC; Yang W; Zhang B; Magnuson S Bioorg Med Chem Lett; 2017 Sep; 27(18):4370-4376. PubMed ID: 28830649 [TBL] [Abstract][Full Text] [Related]
15. Discovery of Tyk2 inhibitors via the virtual site-directed fragment-based drug design. Jang WD; Kim JT; Son HY; Park SY; Cho YS; Koo TS; Lee H; Kang NS Bioorg Med Chem Lett; 2015 Sep; 25(18):3947-52. PubMed ID: 26231159 [TBL] [Abstract][Full Text] [Related]
16. Structure-Based Design and Synthesis of 3-Amino-1,5-dihydro-4H-pyrazolopyridin-4-one Derivatives as Tyrosine Kinase 2 Inhibitors. Yogo T; Nagamiya H; Seto M; Sasaki S; Shih-Chung H; Ohba Y; Tokunaga N; Lee GN; Rhim CY; Yoon CH; Cho SY; Skene R; Yamamoto S; Satou Y; Kuno M; Miyazaki T; Nakagawa H; Okabe A; Marui S; Aso K; Yoshida M J Med Chem; 2016 Jan; 59(2):733-49. PubMed ID: 26701356 [TBL] [Abstract][Full Text] [Related]
17. Discovery of selective TYK2 inhibitors: Design, synthesis, in vitro and in silico studies of promising hits with triazolopyrimidinone scaffold. Istanbullu H; Coban G; Turunc E; Disel C; Debelec Butuner B Bioorg Chem; 2024 Jul; 148():107430. PubMed ID: 38728909 [TBL] [Abstract][Full Text] [Related]