166 related articles for article (PubMed ID: 24387325)
1. Design, synthesis, and biological evaluation of potent dual agonists of nuclear and membrane bile acid receptors.
D'Amore C; Di Leva FS; Sepe V; Renga B; Del Gaudio C; D'Auria MV; Zampella A; Fiorucci S; Limongelli V
J Med Chem; 2014 Feb; 57(3):937-54. PubMed ID: 24387325
[TBL] [Abstract][Full Text] [Related]
2. Exploitation of cholane scaffold for the discovery of potent and selective farnesoid X receptor (FXR) and G-protein coupled bile acid receptor 1 (GP-BAR1) ligands.
Festa C; Renga B; D'Amore C; Sepe V; Finamore C; De Marino S; Carino A; Cipriani S; Monti MC; Zampella A; Fiorucci S
J Med Chem; 2014 Oct; 57(20):8477-95. PubMed ID: 25247751
[TBL] [Abstract][Full Text] [Related]
3. Modification on ursodeoxycholic acid (UDCA) scaffold. discovery of bile acid derivatives as selective agonists of cell-surface G-protein coupled bile acid receptor 1 (GP-BAR1).
Sepe V; Renga B; Festa C; D'Amore C; Masullo D; Cipriani S; Di Leva FS; Monti MC; Novellino E; Limongelli V; Zampella A; Fiorucci S
J Med Chem; 2014 Sep; 57(18):7687-701. PubMed ID: 25162837
[TBL] [Abstract][Full Text] [Related]
4. Introduction of Nonacidic Side Chains on 6-Ethylcholane Scaffolds in the Identification of Potent Bile Acid Receptor Agonists with Improved Pharmacokinetic Properties.
Finamore C; Baronissi G; Marchianò S; Di Leva FS; Carino A; Monti MC; Limongelli V; Zampella A; Fiorucci S; Sepe V
Molecules; 2019 Mar; 24(6):. PubMed ID: 30884797
[TBL] [Abstract][Full Text] [Related]
5. Targeting FXR in cholestasis: hype or hope.
Fiorucci S; Distrutti E; Ricci P; Giuliano V; Donini A; Baldelli F
Expert Opin Ther Targets; 2014 Dec; 18(12):1449-59. PubMed ID: 25200104
[TBL] [Abstract][Full Text] [Related]
6. Stereoselective synthesis, biological evaluation, and modeling of novel bile acid-derived G-protein coupled bile acid receptor 1 (GP-BAR1, TGR5) agonists.
Yu DD; Sousa KM; Mattern DL; Wagner J; Fu X; Vaidehi N; Forman BM; Huang W
Bioorg Med Chem; 2015 Apr; 23(7):1613-28. PubMed ID: 25735208
[TBL] [Abstract][Full Text] [Related]
7. Identification of potential dual agonists of FXR and TGR5 using e-pharmacophore based virtual screening.
Sindhu T; Srinivasan P
Mol Biosyst; 2015 May; 11(5):1305-18. PubMed ID: 25787676
[TBL] [Abstract][Full Text] [Related]
8. Bile-acid-activated receptors: targeting TGR5 and farnesoid-X-receptor in lipid and glucose disorders.
Fiorucci S; Mencarelli A; Palladino G; Cipriani S
Trends Pharmacol Sci; 2009 Nov; 30(11):570-80. PubMed ID: 19758712
[TBL] [Abstract][Full Text] [Related]
9. Marine sponge steroids as nuclear receptor ligands.
Fiorucci S; Distrutti E; Bifulco G; D'Auria MV; Zampella A
Trends Pharmacol Sci; 2012 Nov; 33(11):591-601. PubMed ID: 23000093
[TBL] [Abstract][Full Text] [Related]
10. Navigation in bile acid chemical space: discovery of novel FXR and GPBAR1 ligands.
Finamore C; Festa C; Renga B; Sepe V; Carino A; Masullo D; Biagioli M; Marchianò S; Capolupo A; Monti MC; Fiorucci S; Zampella A
Sci Rep; 2016 Jul; 6():29320. PubMed ID: 27381677
[TBL] [Abstract][Full Text] [Related]
11. Insights on FXR selective modulation. Speculation on bile acid chemical space in the discovery of potent and selective agonists.
Sepe V; Festa C; Renga B; Carino A; Cipriani S; Finamore C; Masullo D; Del Gaudio F; Monti MC; Fiorucci S; Zampella A
Sci Rep; 2016 Jan; 6():19008. PubMed ID: 26740187
[TBL] [Abstract][Full Text] [Related]
12. Investigation on bile acid receptor regulators. Discovery of cholanoic acid derivatives with dual G-protein coupled bile acid receptor 1 (GPBAR1) antagonistic and farnesoid X receptor (FXR) modulatory activity.
Sepe V; Renga B; Festa C; Finamore C; Masullo D; Carino A; Cipriani S; Distrutti E; Fiorucci S; Zampella A
Steroids; 2016 Jan; 105():59-67. PubMed ID: 26607331
[TBL] [Abstract][Full Text] [Related]
13. Nongenomic actions of bile acids. Synthesis and preliminary characterization of 23- and 6,23-alkyl-substituted bile acid derivatives as selective modulators for the G-protein coupled receptor TGR5.
Pellicciari R; Sato H; Gioiello A; Costantino G; Macchiarulo A; Sadeghpour BM; Giorgi G; Schoonjans K; Auwerx J
J Med Chem; 2007 Sep; 50(18):4265-8. PubMed ID: 17685603
[TBL] [Abstract][Full Text] [Related]
14. SAR studies on FXR modulators led to the discovery of the first combined FXR antagonistic/TGR5 agonistic compound.
Lamers C; Merk D; Gabler M; Flesch D; Kaiser A; Schubert-Zsilavecz M
Future Med Chem; 2016; 8(2):133-48. PubMed ID: 26824277
[TBL] [Abstract][Full Text] [Related]
15. Structure-based drug design targeting the cell membrane receptor GPBAR1: exploiting the bile acid scaffold towards selective agonism.
Di Leva FS; Festa C; Renga B; Sepe V; Novellino E; Fiorucci S; Zampella A; Limongelli V
Sci Rep; 2015 Nov; 5():16605. PubMed ID: 26567894
[TBL] [Abstract][Full Text] [Related]
16. Anthranilic acid derivatives as novel ligands for farnesoid X receptor (FXR).
Merk D; Gabler M; Gomez RC; Flesch D; Hanke T; Kaiser A; Lamers C; Werz O; Schneider G; Schubert-Zsilavecz M
Bioorg Med Chem; 2014 Apr; 22(8):2447-60. PubMed ID: 24685112
[TBL] [Abstract][Full Text] [Related]
17. Extending the structure-activity relationship of anthranilic acid derivatives as farnesoid X receptor modulators: development of a highly potent partial farnesoid X receptor agonist.
Merk D; Lamers C; Ahmad K; Carrasco Gomez R; Schneider G; Steinhilber D; Schubert-Zsilavecz M
J Med Chem; 2014 Oct; 57(19):8035-55. PubMed ID: 25255039
[TBL] [Abstract][Full Text] [Related]
18. Chemistry and Pharmacology of GPBAR1 and FXR Selective Agonists, Dual Agonists, and Antagonists.
De Marino S; Festa C; Sepe V; Zampella A
Handb Exp Pharmacol; 2019; 256():137-165. PubMed ID: 31201554
[TBL] [Abstract][Full Text] [Related]
19. Discovery of new non-steroidal farnesoid X receptor modulators through 3D shape similarity search and structure-based virtual screening.
Wang L; Si P; Sheng Y; Chen Y; Wan P; Shen X; Tang Y; Chen L; Li W
Chem Biol Drug Des; 2015 Apr; 85(4):481-7. PubMed ID: 25228339
[TBL] [Abstract][Full Text] [Related]
20. Binding mechanism of the farnesoid X receptor marine antagonist suvanine reveals a strategy to forestall drug modulation on nuclear receptors. Design, synthesis, and biological evaluation of novel ligands.
Di Leva FS; Festa C; D'Amore C; De Marino S; Renga B; D'Auria MV; Novellino E; Limongelli V; Zampella A; Fiorucci S
J Med Chem; 2013 Jun; 56(11):4701-17. PubMed ID: 23656455
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
