BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

189 related articles for article (PubMed ID: 24415188)

  • 1. Dual inhibitors of Janus kinase 2 and 3 (JAK2/3): designing by pharmacophore- and docking-based virtual screening approach.
    Jasuja H; Chadha N; Kaur M; Silakari O
    Mol Divers; 2014 May; 18(2):253-67. PubMed ID: 24415188
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Pharmacophore and docking-based virtual screening approach for the design of new dual inhibitors of Janus kinase 1 and Janus kinase 2.
    Jasuja H; Chadha N; Kaur M; Silakari O
    SAR QSAR Environ Res; 2014; 25(8):617-36. PubMed ID: 25148044
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Putative dual inhibitors of Janus kinase 1 and 3 (JAK1/3): Pharmacophore based hierarchical virtual screening.
    Jasuja H; Chadha N; Singh PK; Kaur M; Bahia MS; Silakari O
    Comput Biol Chem; 2018 Oct; 76():109-117. PubMed ID: 29990790
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Ligand-based and e-pharmacophore modeling, 3D-QSAR and hierarchical virtual screening to identify dual inhibitors of spleen tyrosine kinase (Syk) and janus kinase 3 (JAK3).
    Kaur M; Silakari O
    J Biomol Struct Dyn; 2017 Nov; 35(14):3043-3060. PubMed ID: 27678281
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of highly potent, selective, covalent inhibitors of JAK3.
    Kempson J; Ovalle D; Guo J; Wrobleski ST; Lin S; Spergel SH; Duan JJ; Jiang B; Lu Z; Das J; Yang BV; Hynes J; Wu H; Tokarski J; Sack JS; Khan J; Schieven G; Blatt Y; Chaudhry C; Salter-Cid LM; Fura A; Barrish JC; Carter PH; Pitts WJ
    Bioorg Med Chem Lett; 2017 Oct; 27(20):4622-4625. PubMed ID: 28927786
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Molecular dynamics and integrated pharmacophore-based identification of dual [Formula: see text] inhibitors.
    Kaur M; Singh PK; Singh M; Bahadur R; Silakari O
    Mol Divers; 2018 Feb; 22(1):95-112. PubMed ID: 29138965
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inhibition of Janus kinases by tyrosine phosphorylation inhibitor, Tyrphostin AG-490.
    Rashid S; Bibi N; Parveen Z; Shafique S
    J Biomol Struct Dyn; 2015; 33(11):2368-79. PubMed ID: 26017266
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Inhibitors of JAK2 and JAK3: an update on the patent literature 2010 - 2012.
    Dymock BW; See CS
    Expert Opin Ther Pat; 2013 Apr; 23(4):449-501. PubMed ID: 23367873
    [TBL] [Abstract][Full Text] [Related]  

  • 9. In silico discovery of potent and selective Janus kinase 3 (JAK3) inhibitors through 3D-QSAR, covalent docking, ADMET analysis, molecular dynamics simulations, and binding free energy of pyrazolopyrimidine derivatives.
    Faris A; Hadni H; Ibrahim IM; Elhallaoui M
    J Biomol Struct Dyn; 2024 Jun; 42(9):4817-4833. PubMed ID: 37338041
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Designing of new multi-targeted inhibitors of spleen tyrosine kinase (Syk) and zeta-associated protein of 70kDa (ZAP-70) using hierarchical virtual screening protocol.
    Kaur M; Kumari A; Bahia MS; Silakari O
    J Mol Graph Model; 2013 Feb; 39():165-75. PubMed ID: 23280414
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Strategic use of conformational bias and structure based design to identify potent JAK3 inhibitors with improved selectivity against the JAK family and the kinome.
    Lynch SM; DeVicente J; Hermann JC; Jaime-Figueroa S; Jin S; Kuglstatter A; Li H; Lovey A; Menke J; Niu L; Patel V; Roy D; Soth M; Steiner S; Tivitmahaisoon P; Vu MD; Yee C
    Bioorg Med Chem Lett; 2013 May; 23(9):2793-800. PubMed ID: 23540648
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Diamino-1,2,4-triazole derivatives are selective inhibitors of TYK2 and JAK1 over JAK2 and JAK3.
    Malerich JP; Lam JS; Hart B; Fine RM; Klebansky B; Tanga MJ; D'Andrea A
    Bioorg Med Chem Lett; 2010 Dec; 20(24):7454-7. PubMed ID: 21106455
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structure-based design and synthesis of pyrimidine-4,6-diamine derivatives as Janus kinase 3 inhibitors.
    Yu RN; Chen CJ; Shu L; Yin Y; Wang ZJ; Zhang TT; Zhang DY
    Bioorg Med Chem; 2019 Apr; 27(8):1646-1657. PubMed ID: 30853331
    [TBL] [Abstract][Full Text] [Related]  

  • 14. 9H-Carbazole-1-carboxamides as potent and selective JAK2 inhibitors.
    Zimmermann K; Sang X; Mastalerz HA; Johnson WL; Zhang G; Liu Q; Batt D; Lombardo LJ; Vyas D; Trainor GL; Tokarski JS; Lorenzi MV; You D; Gottardis MM; Lippy J; Khan J; Sack JS; Purandare AV
    Bioorg Med Chem Lett; 2015 Jul; 25(14):2809-12. PubMed ID: 25987372
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Integration of fingerprint-based similarity searching and kernel-based partial least squares analysis to predict inhibitory activity against CSK, HER2, JAK1, JAK2, and JAK3.
    Deokar H; Deokar M; Buolamwini JK
    Mol Divers; 2024 Apr; 28(2):497-507. PubMed ID: 36648693
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Jak2 inhibitor--a jackpot for pharmaceutical industries: a comprehensive computational method in the discovery of new potent Jak2 inhibitors.
    Singh KhD; Naveena Q; Karthikeyan M
    Mol Biosyst; 2014 Aug; 10(8):2146-59. PubMed ID: 24874539
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Searching for Novel Janus Kinase-2 Inhibitors Using a Combination of Pharmacophore Modeling, 3D-QSAR Studies and Virtual Screening.
    Vrontaki E; Melagraki G; Afantitis A; Mavromoustakos T; Kollias G
    Mini Rev Med Chem; 2017; 17(3):268-294. PubMed ID: 27659251
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The discovery of 2,5-isomers of triazole-pyrrolopyrimidine as selective Janus kinase 2 (JAK2) inhibitors versus JAK1 and JAK3.
    Lee SM; Yoon KB; Lee HJ; Kim J; Chung YK; Cho WJ; Mukai C; Choi S; Kang KW; Han SY; Ko H; Kim YC
    Bioorg Med Chem; 2016 Nov; 24(21):5036-5046. PubMed ID: 27555284
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Field-based 3D-QSAR for tyrosine protein kinase JAK-2 inhibitors.
    Andole S; Thumma G; Alavala RR; Gangarapu K
    J Biomol Struct Dyn; 2024 Jul; 42(10):5321-5333. PubMed ID: 37409931
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Discovery of Subtype Selective Janus Kinase (JAK) Inhibitors by Structure-Based Virtual Screening.
    Bajusz D; Ferenczy GG; Keserű GM
    J Chem Inf Model; 2016 Jan; 56(1):234-47. PubMed ID: 26682735
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.