BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

85 related articles for article (PubMed ID: 24422556)

  • 1. Substrate interaction dynamics and oxygen control in the active site of thymidylate synthase ThyX.
    Becker HF; Djaout K; Lamarre I; Ulmer JE; Schaming D; Balland V; Liebl U; Myllykallio H; Vos MH
    Biochem J; 2014 Apr; 459(1):37-45. PubMed ID: 24422556
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Functional analysis of FAD-dependent thymidylate synthase ThyX from Paramecium bursaria Chlorella virus-1.
    Graziani S; Xia Y; Gurnon JR; Van Etten JL; Leduc D; Skouloubris S; Myllykallio H; Liebl U
    J Biol Chem; 2004 Dec; 279(52):54340-7. PubMed ID: 15471872
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Ultrafast dynamics of fully reduced flavin in catalytic structures of thymidylate synthase ThyX.
    Dozova N; Lacombat F; Lombard M; Hamdane D; Plaza P
    Phys Chem Chem Phys; 2021 Oct; 23(39):22692-22702. PubMed ID: 34605505
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Detection of intermediates in the oxidative half-reaction of the FAD-dependent thymidylate synthase from Thermotoga maritima: carbon transfer without covalent pyrimidine activation.
    Conrad JA; Ortiz-Maldonado M; Hoppe SW; Palfey BA
    Biochemistry; 2014 Aug; 53(32):5199-207. PubMed ID: 25068636
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of an acyclic nucleoside phosphonate that inhibits Mycobacterium tuberculosis ThyX based on the binding mode of a 5-alkynyl substrate analogue.
    Parchina A; Froeyen M; Margamuljana L; Rozenski J; De Jonghe S; Briers Y; Lavigne R; Herdewijn P; Lescrinier E
    ChemMedChem; 2013 Aug; 8(8):1373-83. PubMed ID: 23836539
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Thermal stability and binding energetics of thymidylate synthase ThyX.
    Krumova S; Todinova S; Tileva M; Bouzhir-Sima L; Vos MH; Liebl U; Taneva SG
    Int J Biol Macromol; 2016 Oct; 91():560-7. PubMed ID: 27268384
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Ultrafast real-time visualization of active site flexibility of flavoenzyme thymidylate synthase ThyX.
    Laptenok SP; Bouzhir-Sima L; Lambry JC; Myllykallio H; Liebl U; Vos MH
    Proc Natl Acad Sci U S A; 2013 May; 110(22):8924-9. PubMed ID: 23671075
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Functional analysis of the Mycobacterium tuberculosis FAD-dependent thymidylate synthase, ThyX, reveals new amino acid residues contributing to an extended ThyX motif.
    Ulmer JE; Boum Y; Thouvenel CD; Myllykallio H; Sibley CH
    J Bacteriol; 2008 Mar; 190(6):2056-64. PubMed ID: 18192395
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Crystal structure of a flavin-dependent thymidylate synthase from Helicobacter pylori strain 26695.
    Zhang X; Zhang J; Guo G; Mao X; Hu Y; Zou Q
    Protein Pept Lett; 2012 Nov; 19(11):1225-30. PubMed ID: 22512654
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Functional evidence for active site location of tetrameric thymidylate synthase X at the interphase of three monomers.
    Leduc D; Graziani S; Lipowski G; Marchand C; Le Maréchal P; Liebl U; Myllykallio H
    Proc Natl Acad Sci U S A; 2004 May; 101(19):7252-7. PubMed ID: 15123820
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Structure of the Mycobacterium tuberculosis flavin dependent thymidylate synthase (MtbThyX) at 2.0A resolution.
    Sampathkumar P; Turley S; Ulmer JE; Rhie HG; Sibley CH; Hol WG
    J Mol Biol; 2005 Oct; 352(5):1091-104. PubMed ID: 16139296
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis and evaluation of 6-aza-2'-deoxyuridine monophosphate analogs as inhibitors of thymidylate synthases, and as substrates or inhibitors of thymidine monophosphate kinase in Mycobacterium tuberculosis.
    Kögler M; Busson R; De Jonghe S; Rozenski J; Van Belle K; Louat T; Munier-Lehmann H; Herdewijn P
    Chem Biodivers; 2012 Mar; 9(3):536-56. PubMed ID: 22422522
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Deprotonations in the Reaction of Flavin-Dependent Thymidylate Synthase.
    Stull FW; Bernard SM; Sapra A; Smith JL; Zuiderweg ER; Palfey BA
    Biochemistry; 2016 Jun; 55(23):3261-9. PubMed ID: 27214228
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Direct observation of the participation of flavin in product formation by thyX-encoded thymidylate synthase.
    Gattis SG; Palfey BA
    J Am Chem Soc; 2005 Jan; 127(3):832-3. PubMed ID: 15656610
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Kinetic scheme for thymidylate synthase from Escherichia coli: determination from measurements of ligand binding, primary and secondary isotope effects, and pre-steady-state catalysis.
    Spencer HT; Villafranca JE; Appleman JR
    Biochemistry; 1997 Apr; 36(14):4212-22. PubMed ID: 9100016
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mechanism of Naphthoquinone Selectivity of Thymidylate Synthase ThyX.
    Myllykallio H; Becker HF; Aleksandrov A
    Biophys J; 2020 Dec; 119(12):2508-2516. PubMed ID: 33217379
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Catalytic mechanism and structure of viral flavin-dependent thymidylate synthase ThyX.
    Graziani S; Bernauer J; Skouloubris S; Graille M; Zhou CZ; Marchand C; Decottignies P; van Tilbeurgh H; Myllykallio H; Liebl U
    J Biol Chem; 2006 Aug; 281(33):24048-57. PubMed ID: 16707489
    [TBL] [Abstract][Full Text] [Related]  

  • 18. NADP+ expels both the co-factor and a substrate analog from the Mycobacterium tuberculosis ThyX active site: opportunities for anti-bacterial drug design.
    Sampathkumar P; Turley S; Sibley CH; Hol WG
    J Mol Biol; 2006 Jun; 360(1):1-6. PubMed ID: 16730023
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Effect of halogen substitutions on dUMP to stability of thymidylate synthase/dUMP/mTHF ternary complex using molecular dynamics simulation.
    Kaiyawet N; Rungrotmongkol T; Hannongbua S
    J Chem Inf Model; 2013 Jun; 53(6):1315-23. PubMed ID: 23705822
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Mechanistic and structural basis for inhibition of thymidylate synthase ThyX.
    Basta T; Boum Y; Briffotaux J; Becker HF; Lamarre-Jouenne I; Lambry JC; Skouloubris S; Liebl U; Graille M; van Tilbeurgh H; Myllykallio H
    Open Biol; 2012 Oct; 2(10):120120. PubMed ID: 23155486
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.