BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

538 related articles for article (PubMed ID: 24433041)

  • 1. Minireview: More than just a hammer: ligand "bias" and pharmaceutical discovery.
    Luttrell LM
    Mol Endocrinol; 2014 Mar; 28(3):281-94. PubMed ID: 24433041
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Fulfilling the Promise of "Biased" G Protein-Coupled Receptor Agonism.
    Luttrell LM; Maudsley S; Bohn LM
    Mol Pharmacol; 2015 Sep; 88(3):579-88. PubMed ID: 26134495
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Translating in vitro ligand bias into in vivo efficacy.
    Luttrell LM; Maudsley S; Gesty-Palmer D
    Cell Signal; 2018 Jan; 41():46-55. PubMed ID: 28495495
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Biasing the parathyroid hormone receptor: relating in vitro ligand efficacy to in vivo biological activity.
    Appleton KM; Lee MH; Alele C; Alele C; Luttrell DK; Peterson YK; Morinelli TA; Luttrell LM
    Methods Enzymol; 2013; 522():229-62. PubMed ID: 23374189
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Refining efficacy: exploiting functional selectivity for drug discovery.
    Gesty-Palmer D; Luttrell LM
    Adv Pharmacol; 2011; 62():79-107. PubMed ID: 21907907
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Biased agonism at the parathyroid hormone receptor: a demonstration of functional selectivity in bone metabolism.
    Bohinc BN; Gesty-Palmer D
    Mini Rev Med Chem; 2012 Aug; 12(9):856-65. PubMed ID: 22681253
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Arrestin pathways as drug targets.
    Luttrell LM
    Prog Mol Biol Transl Sci; 2013; 118():469-97. PubMed ID: 23764065
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors.
    Reiter E; Ahn S; Shukla AK; Lefkowitz RJ
    Annu Rev Pharmacol Toxicol; 2012; 52():179-97. PubMed ID: 21942629
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Biased agonism: An emerging paradigm in GPCR drug discovery.
    Rankovic Z; Brust TF; Bohn LM
    Bioorg Med Chem Lett; 2016 Jan; 26(2):241-250. PubMed ID: 26707396
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Unravelling intrinsic efficacy and ligand bias at G protein coupled receptors: A practical guide to assessing functional data.
    Stott LA; Hall DA; Holliday ND
    Biochem Pharmacol; 2016 Feb; 101():1-12. PubMed ID: 26478533
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Orthosteric- and allosteric-induced ligand-directed trafficking at GPCRs.
    Digby GJ; Conn PJ; Lindsley CW
    Curr Opin Drug Discov Devel; 2010 Sep; 13(5):587-94. PubMed ID: 20812150
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Biased ligands for better cardiovascular drugs: dissecting G-protein-coupled receptor pharmacology.
    DeWire SM; Violin JD
    Circ Res; 2011 Jul; 109(2):205-16. PubMed ID: 21737816
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Elucidating structural and molecular mechanisms of β-arrestin-biased agonism at GPCRs via MS-based proteomics.
    Xiao K; Sun J
    Cell Signal; 2018 Jan; 41():56-64. PubMed ID: 28939107
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Allosteric coupling and biased agonism in G protein-coupled receptors.
    Bock A; Bermudez M
    FEBS J; 2021 Apr; 288(8):2513-2528. PubMed ID: 33621418
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Biased Allosteric Modulators: New Frontiers in GPCR Drug Discovery.
    Slosky LM; Caron MG; Barak LS
    Trends Pharmacol Sci; 2021 Apr; 42(4):283-299. PubMed ID: 33581873
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A kinetic view of GPCR allostery and biased agonism.
    Lane JR; May LT; Parton RG; Sexton PM; Christopoulos A
    Nat Chem Biol; 2017 Aug; 13(9):929-937. PubMed ID: 28820879
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Biased agonism at G protein-coupled receptors: the promise and the challenges--a medicinal chemistry perspective.
    Shonberg J; Lopez L; Scammells PJ; Christopoulos A; Capuano B; Lane JR
    Med Res Rev; 2014 Nov; 34(6):1286-330. PubMed ID: 24796277
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Biased ligands at G-protein-coupled receptors: promise and progress.
    Violin JD; Crombie AL; Soergel DG; Lark MW
    Trends Pharmacol Sci; 2014 Jul; 35(7):308-16. PubMed ID: 24878326
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Emergent biological properties of arrestin pathway-selective biased agonism.
    Appleton KM; Luttrell LM
    J Recept Signal Transduct Res; 2013 Jun; 33(3):153-61. PubMed ID: 23448506
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Beta-arrestin biased agonism/antagonism at cardiovascular seven transmembrane-spanning receptors.
    Lymperopoulos A
    Curr Pharm Des; 2012; 18(2):192-8. PubMed ID: 22229558
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 27.