BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

147 related articles for article (PubMed ID: 24447917)

  • 1. The convergence of endosomal and autophagosomal pathways: implications for APP-CTF degradation.
    Tian Y; Chang JC; Greengard P; Flajolet M
    Autophagy; 2014 Apr; 10(4):694-6. PubMed ID: 24447917
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy.
    Tian Y; Chang JC; Fan EY; Flajolet M; Greengard P
    Proc Natl Acad Sci U S A; 2013 Oct; 110(42):17071-6. PubMed ID: 24067654
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Decreasing the expression of PICALM reduces endocytosis and the activity of β-secretase: implications for Alzheimer's disease.
    Thomas RS; Henson A; Gerrish A; Jones L; Williams J; Kidd EJ
    BMC Neurosci; 2016 Jul; 17(1):50. PubMed ID: 27430330
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway.
    Tian Y; Bustos V; Flajolet M; Greengard P
    FASEB J; 2011 Jun; 25(6):1934-42. PubMed ID: 21368103
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Role of phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia (PICALM) in intracellular amyloid precursor protein (APP) processing and amyloid plaque pathogenesis.
    Xiao Q; Gil SC; Yan P; Wang Y; Han S; Gonzales E; Perez R; Cirrito JR; Lee JM
    J Biol Chem; 2012 Jun; 287(25):21279-89. PubMed ID: 22539346
    [TBL] [Abstract][Full Text] [Related]  

  • 6. NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation.
    Cai CZ; Yang C; Zhuang XX; Yuan NN; Wu MY; Tan JQ; Song JX; Cheung KH; Su H; Wang YT; Tang BS; Behrends C; Durairajan SSK; Yue Z; Li M; Lu JH
    Autophagy; 2021 May; 17(5):1112-1130. PubMed ID: 32543313
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The role of PTB domain containing adaptor proteins on PICALM-mediated APP endocytosis and localization.
    Merthan L; Haller A; Thal DR; von Einem B; von Arnim CAF
    Biochem J; 2019 Jul; 476(14):2093-2109. PubMed ID: 31300465
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Regulation of amyloid precursor protein processing by the Beclin 1 complex.
    Jaeger PA; Pickford F; Sun CH; Lucin KM; Masliah E; Wyss-Coray T
    PLoS One; 2010 Jun; 5(6):e11102. PubMed ID: 20559548
    [TBL] [Abstract][Full Text] [Related]  

  • 9. High glucose-mediated PICALM and mTORC1 modulate processing of amyloid precursor protein via endosomal abnormalities.
    Chae CW; Lee HJ; Choi GE; Jung YH; Kim JS; Lim JR; Kim SY; Hwang IK; Seong JK; Han HJ
    Br J Pharmacol; 2020 Aug; 177(16):3828-3847. PubMed ID: 32436237
    [TBL] [Abstract][Full Text] [Related]  

  • 10. APP overexpression in the absence of NPC1 exacerbates metabolism of amyloidogenic proteins of Alzheimer's disease.
    Maulik M; Peake K; Chung J; Wang Y; Vance JE; Kar S
    Hum Mol Genet; 2015 Dec; 24(24):7132-50. PubMed ID: 26433932
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome.
    Salminen A; Kaarniranta K; Kauppinen A; Ojala J; Haapasalo A; Soininen H; Hiltunen M
    Prog Neurobiol; 2013; 106-107():33-54. PubMed ID: 23827971
    [TBL] [Abstract][Full Text] [Related]  

  • 12. CD2-associated protein (CD2AP) overexpression accelerates amyloid precursor protein (APP) transfer from early endosomes to the lysosomal degradation pathway.
    Furusawa K; Takasugi T; Chiu YW; Hori Y; Tomita T; Fukuda M; Hisanaga SI
    J Biol Chem; 2019 Jul; 294(28):10886-10899. PubMed ID: 31138646
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Macroautophagy is not directly involved in the metabolism of amyloid precursor protein.
    Boland B; Smith DA; Mooney D; Jung SS; Walsh DM; Platt FM
    J Biol Chem; 2010 Nov; 285(48):37415-26. PubMed ID: 20864542
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Reduction of brain beta-amyloid (Abeta) by fluvastatin, a hydroxymethylglutaryl-CoA reductase inhibitor, through increase in degradation of amyloid precursor protein C-terminal fragments (APP-CTFs) and Abeta clearance.
    Shinohara M; Sato N; Kurinami H; Takeuchi D; Takeda S; Shimamura M; Yamashita T; Uchiyama Y; Rakugi H; Morishita R
    J Biol Chem; 2010 Jul; 285(29):22091-102. PubMed ID: 20472556
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration.
    Xu W; Weissmiller AM; White JA; Fang F; Wang X; Wu Y; Pearn ML; Zhao X; Sawa M; Chen S; Gunawardena S; Ding J; Mobley WC; Wu C
    J Clin Invest; 2016 May; 126(5):1815-33. PubMed ID: 27064279
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments.
    Guix FX; Sannerud R; Berditchevski F; Arranz AM; Horré K; Snellinx A; Thathiah A; Saido T; Saito T; Rajesh S; Overduin M; Kumar-Singh S; Radaelli E; Corthout N; Colombelli J; Tosi S; Munck S; Salas IH; Annaert W; De Strooper B
    Mol Neurodegener; 2017 Mar; 12(1):25. PubMed ID: 28279219
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production.
    Grbovic OM; Mathews PM; Jiang Y; Schmidt SD; Dinakar R; Summers-Terio NB; Ceresa BP; Nixon RA; Cataldo AM
    J Biol Chem; 2003 Aug; 278(33):31261-8. PubMed ID: 12761223
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Altered γ-Secretase Processing of APP Disrupts Lysosome and Autophagosome Function in Monogenic Alzheimer's Disease.
    Hung COY; Livesey FJ
    Cell Rep; 2018 Dec; 25(13):3647-3660.e2. PubMed ID: 30590039
    [TBL] [Abstract][Full Text] [Related]  

  • 19. TFEB-mediated Enhancement of the Autophagy-lysosomal Pathway Dually Modulates the Process of Amyloid β-Protein Generation in Neurons.
    Yamamoto F; Taniguchi K; Mamada N; Tamaoka A; Kametani F; Lakshmana MK; Araki W
    Neuroscience; 2019 Mar; 402():11-22. PubMed ID: 30677488
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model.
    Luo R; Su LY; Li G; Yang J; Liu Q; Yang LX; Zhang DF; Zhou H; Xu M; Fan Y; Li J; Yao YG
    Autophagy; 2020 Jan; 16(1):52-69. PubMed ID: 30898012
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.