474 related articles for article (PubMed ID: 24459107)
1. HTT-lowering reverses Huntington's disease immune dysfunction caused by NFκB pathway dysregulation.
Träger U; Andre R; Lahiri N; Magnusson-Lind A; Weiss A; Grueninger S; McKinnon C; Sirinathsinghji E; Kahlon S; Pfister EL; Moser R; Hummerich H; Antoniou M; Bates GP; Luthi-Carter R; Lowdell MW; Björkqvist M; Ostroff GR; Aronin N; Tabrizi SJ
Brain; 2014 Mar; 137(Pt 3):819-33. PubMed ID: 24459107
[TBL] [Abstract][Full Text] [Related]
2. RNA-Seq of Huntington's disease patient myeloid cells reveals innate transcriptional dysregulation associated with proinflammatory pathway activation.
Miller JR; Lo KK; Andre R; Hensman Moss DJ; Träger U; Stone TC; Jones L; Holmans P; Plagnol V; Tabrizi SJ
Hum Mol Genet; 2016 Jul; 25(14):2893-2904. PubMed ID: 27170315
[TBL] [Abstract][Full Text] [Related]
3. Mutant Huntingtin Does Not Affect the Intrinsic Phenotype of Human Huntington's Disease T Lymphocytes.
Miller JR; Träger U; Andre R; Tabrizi SJ
PLoS One; 2015; 10(11):e0141793. PubMed ID: 26529236
[TBL] [Abstract][Full Text] [Related]
4. Disruption of immune cell function by mutant huntingtin in Huntington's disease pathogenesis.
Andre R; Carty L; Tabrizi SJ
Curr Opin Pharmacol; 2016 Feb; 26():33-8. PubMed ID: 26461267
[TBL] [Abstract][Full Text] [Related]
5. PRMT5- mediated symmetric arginine dimethylation is attenuated by mutant huntingtin and is impaired in Huntington's disease (HD).
Ratovitski T; Arbez N; Stewart JC; Chighladze E; Ross CA
Cell Cycle; 2015; 14(11):1716-29. PubMed ID: 25927346
[TBL] [Abstract][Full Text] [Related]
6. Downregulation of glial genes involved in synaptic function mitigates Huntington's disease pathogenesis.
Onur TS; Laitman A; Zhao H; Keyho R; Kim H; Wang J; Mair M; Wang H; Li L; Perez A; de Haro M; Wan YW; Allen G; Lu B; Al-Ramahi I; Liu Z; Botas J
Elife; 2021 Apr; 10():. PubMed ID: 33871358
[TBL] [Abstract][Full Text] [Related]
7. Olesoxime suppresses calpain activation and mutant huntingtin fragmentation in the BACHD rat.
Clemens LE; Weber JJ; Wlodkowski TT; Yu-Taeger L; Michaud M; Calaminus C; Eckert SH; Gaca J; Weiss A; Magg JC; Jansson EK; Eckert GP; Pichler BJ; Bordet T; Pruss RM; Riess O; Nguyen HP
Brain; 2015 Dec; 138(Pt 12):3632-53. PubMed ID: 26490331
[TBL] [Abstract][Full Text] [Related]
8. Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets.
Jiang M; Wang J; Fu J; Du L; Jeong H; West T; Xiang L; Peng Q; Hou Z; Cai H; Seredenina T; Arbez N; Zhu S; Sommers K; Qian J; Zhang J; Mori S; Yang XW; Tamashiro KL; Aja S; Moran TH; Luthi-Carter R; Martin B; Maudsley S; Mattson MP; Cichewicz RH; Ross CA; Holtzman DM; Krainc D; Duan W
Nat Med; 2011 Dec; 18(1):153-8. PubMed ID: 22179319
[TBL] [Abstract][Full Text] [Related]
9. Increased Steady-State Mutant Huntingtin mRNA in Huntington's Disease Brain.
Liu W; Chaurette J; Pfister EL; Kennington LA; Chase KO; Bullock J; Vonsattel JP; Faull RL; Macdonald D; DiFiglia M; Zamore PD; Aronin N
J Huntingtons Dis; 2013; 2(4):491-500. PubMed ID: 25062733
[TBL] [Abstract][Full Text] [Related]
10. Six-month partial suppression of Huntingtin is well tolerated in the adult rhesus striatum.
Grondin R; Kaytor MD; Ai Y; Nelson PT; Thakker DR; Heisel J; Weatherspoon MR; Blum JL; Burright EN; Zhang Z; Kaemmerer WF
Brain; 2012 Apr; 135(Pt 4):1197-209. PubMed ID: 22252996
[TBL] [Abstract][Full Text] [Related]
11. Huntingtin and its role in neuronal degeneration.
Li SH; Li XJ
Neuroscientist; 2004 Oct; 10(5):467-75. PubMed ID: 15359012
[TBL] [Abstract][Full Text] [Related]
12. AAV5-miHTT-mediated huntingtin lowering improves brain health in a Huntington's disease mouse model.
Thomson SB; Stam A; Brouwers C; Fodale V; Bresciani A; Vermeulen M; Mostafavi S; Petkau TL; Hill A; Yung A; Russell-Schulz B; Kozlowski P; MacKay A; Ma D; Beg MF; Evers MM; Vallès A; Leavitt BR
Brain; 2023 Jun; 146(6):2298-2315. PubMed ID: 36508327
[TBL] [Abstract][Full Text] [Related]
13. Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity.
Khoshnan A; Ko J; Watkin EE; Paige LA; Reinhart PH; Patterson PH
J Neurosci; 2004 Sep; 24(37):7999-8008. PubMed ID: 15371500
[TBL] [Abstract][Full Text] [Related]
14. Examination of mesenchymal stem cell-mediated RNAi transfer to Huntington's disease affected neuronal cells for reduction of huntingtin.
Olson SD; Kambal A; Pollock K; Mitchell GM; Stewart H; Kalomoiris S; Cary W; Nacey C; Pepper K; Nolta JA
Mol Cell Neurosci; 2012 Mar; 49(3):271-81. PubMed ID: 22198539
[TBL] [Abstract][Full Text] [Related]
15. Laquinimod dampens hyperactive cytokine production in Huntington's disease patient myeloid cells.
Dobson L; Träger U; Farmer R; Hayardeny L; Loupe P; Hayden MR; Tabrizi SJ
J Neurochem; 2016 Jun; 137(5):782-94. PubMed ID: 26823290
[TBL] [Abstract][Full Text] [Related]
16. Transcriptional profiles for distinct aggregation states of mutant Huntingtin exon 1 protein unmask new Huntington's disease pathways.
Moily NS; Ormsby AR; Stojilovic A; Ramdzan YM; Diesch J; Hannan RD; Zajac MS; Hannan AJ; Oshlack A; Hatters DM
Mol Cell Neurosci; 2017 Sep; 83():103-112. PubMed ID: 28743452
[TBL] [Abstract][Full Text] [Related]
17. Mutant huntingtin and glycogen synthase kinase 3-beta accumulate in neuronal lipid rafts of a presymptomatic knock-in mouse model of Huntington's disease.
Valencia A; Reeves PB; Sapp E; Li X; Alexander J; Kegel KB; Chase K; Aronin N; DiFiglia M
J Neurosci Res; 2010 Jan; 88(1):179-90. PubMed ID: 19642201
[TBL] [Abstract][Full Text] [Related]
18. Mutant huntingtin activates Nrf2-responsive genes and impairs dopamine synthesis in a PC12 model of Huntington's disease.
van Roon-Mom WM; Pepers BA; 't Hoen PA; Verwijmeren CA; den Dunnen JT; Dorsman JC; van Ommen GB
BMC Mol Biol; 2008 Oct; 9():84. PubMed ID: 18844975
[TBL] [Abstract][Full Text] [Related]
19. Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series.
Landles C; Bates GP
EMBO Rep; 2004 Oct; 5(10):958-63. PubMed ID: 15459747
[TBL] [Abstract][Full Text] [Related]
20. Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway.
Jeong H; Cohen DE; Cui L; Supinski A; Savas JN; Mazzulli JR; Yates JR; Bordone L; Guarente L; Krainc D
Nat Med; 2011 Dec; 18(1):159-65. PubMed ID: 22179316
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
