These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
162 related articles for article (PubMed ID: 24481871)
1. Structure-based approach to improve a small-molecule inhibitor by the use of a competitive peptide ligand. Ono K; Takeuchi K; Ueda H; Morita Y; Tanimura R; Shimada I; Takahashi H Angew Chem Int Ed Engl; 2014 Mar; 53(10):2597-601. PubMed ID: 24481871 [TBL] [Abstract][Full Text] [Related]
2. Advancing fragment binders to lead-like compounds using ligand and protein-based NMR spectroscopy. Maurer T Methods Enzymol; 2011; 493():469-85. PubMed ID: 21371602 [TBL] [Abstract][Full Text] [Related]
3. Fragment-based ligand discovery. Fischer M; Hubbard RE Mol Interv; 2009 Feb; 9(1):22-30. PubMed ID: 19299661 [TBL] [Abstract][Full Text] [Related]
4. Application of encoded library technology (ELT) to a protein-protein interaction target: discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists. Kollmann CS; Bai X; Tsai CH; Yang H; Lind KE; Skinner SR; Zhu Z; Israel DI; Cuozzo JW; Morgan BA; Yuki K; Xie C; Springer TA; Shimaoka M; Evindar G Bioorg Med Chem; 2014 Apr; 22(7):2353-65. PubMed ID: 24593905 [TBL] [Abstract][Full Text] [Related]
5. Structure-assisted discovery of the first non-retinoid ligands for Retinol-Binding Protein 4. Wang Y; Connors R; Fan P; Wang X; Wang Z; Liu J; Kayser F; Medina JC; Johnstone S; Xu H; Thibault S; Walker N; Conn M; Zhang Y; Liu Q; Grillo MP; Motani A; Coward P; Wang Z Bioorg Med Chem Lett; 2014 Jul; 24(13):2885-91. PubMed ID: 24835984 [TBL] [Abstract][Full Text] [Related]
6. Combining NMR and X-ray crystallography in fragment-based drug discovery: discovery of highly potent and selective BACE-1 inhibitors. Wyss DF; Wang YS; Eaton HL; Strickland C; Voigt JH; Zhu Z; Stamford AW Top Curr Chem; 2012; 317():83-114. PubMed ID: 21647837 [TBL] [Abstract][Full Text] [Related]
7. Discovery of novel A3 adenosine receptor ligands based on chromone scaffold. Gaspar A; Reis J; Kachler S; Paoletta S; Uriarte E; Klotz KN; Moro S; Borges F Biochem Pharmacol; 2012 Jul; 84(1):21-9. PubMed ID: 22433284 [TBL] [Abstract][Full Text] [Related]
8. Structural basis for platelet antiaggregation by angiotensin II type 1 receptor antagonist losartan (DuP-753) via glycoprotein VI. Ono K; Ueda H; Yoshizawa Y; Akazawa D; Tanimura R; Shimada I; Takahashi H J Med Chem; 2010 Mar; 53(5):2087-93. PubMed ID: 20158191 [TBL] [Abstract][Full Text] [Related]
9. Discovery of a small molecular compound simultaneously targeting RXR and HADC: design, synthesis, molecular docking and bioassay. Chen GL; Wang LH; Wang J; Chen K; Zhao M; Sun ZZ; Wang S; Zheng HL; Yang JY; Wu CF Bioorg Med Chem Lett; 2013 Jul; 23(13):3891-5. PubMed ID: 23707260 [TBL] [Abstract][Full Text] [Related]
10. Synergism of virtual screening and medicinal chemistry: identification and optimization of allosteric antagonists of metabotropic glutamate receptor 1. Noeske T; Trifanova D; Kauss V; Renner S; Parsons CG; Schneider G; Weil T Bioorg Med Chem; 2009 Aug; 17(15):5708-15. PubMed ID: 19574055 [TBL] [Abstract][Full Text] [Related]
11. Identification of lead compounds as antagonists of protein Bcl-xL with a diversity-oriented multidisciplinary approach. Di Micco S; Vitale R; Pellecchia M; Rega MF; Riva R; Basso A; Bifulco G J Med Chem; 2009 Dec; 52(23):7856-67. PubMed ID: 19852471 [TBL] [Abstract][Full Text] [Related]
12. Identification of small-molecule inhibitors against human leukocyte antigen-death receptor 4 (HLA-DR4) through a comprehensive strategy. Liu Z; Li B; Li X; Zhang L; Lai L J Chem Inf Model; 2011 Feb; 51(2):326-34. PubMed ID: 21284404 [TBL] [Abstract][Full Text] [Related]
13. Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases. Comess KM; Sun C; Abad-Zapatero C; Goedken ER; Gum RJ; Borhani DW; Argiriadi M; Groebe DR; Jia Y; Clampit JE; Haasch DL; Smith HT; Wang S; Song D; Coen ML; Cloutier TE; Tang H; Cheng X; Quinn C; Liu B; Xin Z; Liu G; Fry EH; Stoll V; Ng TI; Banach D; Marcotte D; Burns DJ; Calderwood DJ; Hajduk PJ ACS Chem Biol; 2011 Mar; 6(3):234-44. PubMed ID: 21090814 [TBL] [Abstract][Full Text] [Related]
14. Identification of small molecule sphingomyelin synthase inhibitors. Deng X; Lin F; Zhang Y; Li Y; Zhou L; Lou B; Li Y; Dong J; Ding T; Jiang X; Wang R; Ye D Eur J Med Chem; 2014 Feb; 73():1-7. PubMed ID: 24374347 [TBL] [Abstract][Full Text] [Related]
15. Protein-ligand-based pharmacophores: generation and utility assessment in computational ligand profiling. Meslamani J; Li J; Sutter J; Stevens A; Bertrand HO; Rognan D J Chem Inf Model; 2012 Apr; 52(4):943-55. PubMed ID: 22480372 [TBL] [Abstract][Full Text] [Related]
16. Fragment based lead discovery of small molecule inhibitors for the EPHA4 receptor tyrosine kinase. van Linden OP; Farenc C; Zoutman WH; Hameetman L; Wijtmans M; Leurs R; Tensen CP; Siegal G; de Esch IJ Eur J Med Chem; 2012 Jan; 47(1):493-500. PubMed ID: 22137457 [TBL] [Abstract][Full Text] [Related]
17. Discovery of a novel selective PPARγ ligand with partial agonist binding properties by integrated in silico/in vitro work flow. Kouskoumvekaki I; Petersen RK; Fratev F; Taboureau O; Nielsen TE; Oprea TI; Sonne SB; Flindt EN; Jónsdóttir SÓ; Kristiansen K J Chem Inf Model; 2013 Apr; 53(4):923-37. PubMed ID: 23432662 [TBL] [Abstract][Full Text] [Related]
18. A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: Structure-based design, synthesis, and biological evaluation. Chiriano G; De Simone A; Mancini F; Perez DI; Cavalli A; Bolognesi ML; Legname G; Martinez A; Andrisano V; Carloni P; Roberti M Eur J Med Chem; 2012 Feb; 48():206-13. PubMed ID: 22209418 [TBL] [Abstract][Full Text] [Related]
19. Selection of DNA-encoded small molecule libraries against unmodified and non-immobilized protein targets. Zhao P; Chen Z; Li Y; Sun D; Gao Y; Huang Y; Li X Angew Chem Int Ed Engl; 2014 Sep; 53(38):10056-9. PubMed ID: 25044298 [TBL] [Abstract][Full Text] [Related]
20. Discovery of small molecule inhibitors of protein-protein interactions using combined ligand and target score normalization. Casey FP; Pihan E; Shields DC J Chem Inf Model; 2009 Dec; 49(12):2708-17. PubMed ID: 19994847 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]