BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

195 related articles for article (PubMed ID: 24489893)

  • 1. A Ser252Trp mutation in fibroblast growth factor receptor 2 (FGFR2) mimicking human Apert syndrome reveals an essential role for FGF signaling in the regulation of endochondral bone formation.
    Chen P; Zhang L; Weng T; Zhang S; Sun S; Chang M; Li Y; Zhang B; Zhang L
    PLoS One; 2014; 9(1):e87311. PubMed ID: 24489893
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A Pro253Arg mutation in fibroblast growth factor receptor 2 (Fgfr2) causes skeleton malformation mimicking human Apert syndrome by affecting both chondrogenesis and osteogenesis.
    Yin L; Du X; Li C; Xu X; Chen Z; Su N; Zhao L; Qi H; Li F; Xue J; Yang J; Jin M; Deng C; Chen L
    Bone; 2008 Apr; 42(4):631-43. PubMed ID: 18242159
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Excessive osteoclast activation by osteoblast paracrine factor RANKL is a major cause of the abnormal long bone phenotype in Apert syndrome model mice.
    Shin HR; Kim BS; Kim HJ; Yoon H; Kim WJ; Choi JY; Ryoo HM
    J Cell Physiol; 2022 Apr; 237(4):2155-2168. PubMed ID: 35048384
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The study of abnormal bone development in the Apert syndrome Fgfr2+/S252W mouse using a 3D hydrogel culture model.
    Yang F; Wang Y; Zhang Z; Hsu B; Jabs EW; Elisseeff JH
    Bone; 2008 Jul; 43(1):55-63. PubMed ID: 18407821
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Apert syndrome mutant FGFR2 and its soluble form reciprocally alter osteogenesis of primary calvarial osteoblasts.
    Suzuki H; Suda N; Shiga M; Kobayashi Y; Nakamura M; Iseki S; Moriyama K
    J Cell Physiol; 2012 Sep; 227(9):3267-77. PubMed ID: 22105374
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Activation of p38 MAPK pathway in the skull abnormalities of Apert syndrome Fgfr2(+P253R) mice.
    Wang Y; Sun M; Uhlhorn VL; Zhou X; Peter I; Martinez-Abadias N; Hill CA; Percival CJ; Richtsmeier JT; Huso DL; Jabs EW
    BMC Dev Biol; 2010 Feb; 10():22. PubMed ID: 20175913
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The Fgfr2(S252W/+) mutation in mice retards mandible formation and reduces bone mass as in human Apert syndrome.
    Zhou X; Pu D; Liu R; Li X; Wen X; Zhang L; Chen L; Deng M; Liu L
    Am J Med Genet A; 2013 May; 161A(5):983-92. PubMed ID: 23495007
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Effects of FGFR Signaling on Cell Proliferation and Differentiation of Apert Dental Cells.
    Lu C; Huguley S; Cui C; Cabaniss LB; Waite PD; Sarver DM; Mamaeva OA; MacDougall M
    Cells Tissues Organs; 2016; 201(1):26-37. PubMed ID: 26613250
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Soluble form of FGFR2 with S252W partially prevents craniosynostosis of the apert mouse model.
    Morita J; Nakamura M; Kobayashi Y; Deng CX; Funato N; Moriyama K
    Dev Dyn; 2014 Apr; 243(4):560-7. PubMed ID: 24259495
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Aberrantly activated Wnt/β-catenin pathway co-receptors LRP5 and LRP6 regulate osteoblast differentiation in the developing coronal sutures of an Apert syndrome (Fgfr2
    Min Swe NM; Kobayashi Y; Kamimoto H; Moriyama K
    Dev Dyn; 2021 Mar; 250(3):465-476. PubMed ID: 32822074
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Inhibited Wnt signaling causes age-dependent abnormalities in the bone matrix mineralization in the Apert syndrome FGFR2(S252W/+) mice.
    Zhang L; Chen P; Chen L; Weng T; Zhang S; Zhou X; Zhang B; Liu L
    PLoS One; 2015; 10(2):e112716. PubMed ID: 25693202
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Increased expression of protein kinase Calpha, interleukin-1alpha, and RhoA guanosine 5'-triphosphatase in osteoblasts expressing the Ser252Trp fibroblast growth factor 2 receptor Apert mutation: identification by analysis of complementary DNA microarray.
    Lomri A; Lemonnier J; Delannoy P; Marie PJ
    J Bone Miner Res; 2001 Apr; 16(4):705-12. PubMed ID: 11315998
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A soluble form of fibroblast growth factor receptor 2 (FGFR2) with S252W mutation acts as an efficient inhibitor for the enhanced osteoblastic differentiation caused by FGFR2 activation in Apert syndrome.
    Tanimoto Y; Yokozeki M; Hiura K; Matsumoto K; Nakanishi H; Matsumoto T; Marie PJ; Moriyama K
    J Biol Chem; 2004 Oct; 279(44):45926-34. PubMed ID: 15310757
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Dynamic morphological changes in the skulls of mice mimicking human Apert syndrome resulting from gain-of-function mutation of FGFR2 (P253R).
    Du X; Weng T; Sun Q; Su N; Chen Z; Qi H; Jin M; Yin L; He Q; Chen L
    J Anat; 2010 Aug; 217(2):97-105. PubMed ID: 20557404
    [TBL] [Abstract][Full Text] [Related]  

  • 15. FGFR2 mutation confers a less drastic gain of function in mesenchymal stem cells than in fibroblasts.
    Yeh E; Atique R; Ishiy FA; Fanganiello RD; Alonso N; Matushita H; da Rocha KM; Passos-Bueno MR
    Stem Cell Rev Rep; 2012 Sep; 8(3):685-95. PubMed ID: 22048896
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A Ser252Trp [corrected] substitution in mouse fibroblast growth factor receptor 2 (Fgfr2) results in craniosynostosis.
    Chen L; Li D; Li C; Engel A; Deng CX
    Bone; 2003 Aug; 33(2):169-78. PubMed ID: 14499350
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Novel molecular pathways elicited by mutant FGFR2 may account for brain abnormalities in Apert syndrome.
    Yeh E; Fanganiello RD; Sunaga DY; Zhou X; Holmes G; Rocha KM; Alonso N; Matushita H; Wang Y; Jabs EW; Passos-Bueno MR
    PLoS One; 2013; 8(4):e60439. PubMed ID: 23593218
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Fibroblast growth factor receptor 2 promotes osteogenic differentiation in mesenchymal cells via ERK1/2 and protein kinase C signaling.
    Miraoui H; Oudina K; Petite H; Tanimoto Y; Moriyama K; Marie PJ
    J Biol Chem; 2009 Feb; 284(8):4897-904. PubMed ID: 19117954
    [TBL] [Abstract][Full Text] [Related]  

  • 19. FGF/FGFR signaling coordinates skull development by modulating magnitude of morphological integration: evidence from Apert syndrome mouse models.
    Martínez-Abadías N; Heuzé Y; Wang Y; Jabs EW; Aldridge K; Richtsmeier JT
    PLoS One; 2011; 6(10):e26425. PubMed ID: 22053191
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Inducible Activation of FGFR2 in Adult Mice Promotes Bone Formation After Bone Marrow Ablation.
    Xu W; Luo F; Wang Q; Tan Q; Huang J; Zhou S; Wang Z; Sun X; Kuang L; Jin M; Su N; Jiang W; Chen L; Qi H; Zhu Y; Chen B; Chen H; Chen S; Gao Y; Xu X; Deng C; Chen L; Xie Y; Du X
    J Bone Miner Res; 2017 Nov; 32(11):2194-2206. PubMed ID: 28650109
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.