BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

541 related articles for article (PubMed ID: 24498134)

  • 1. Evaluation of the endothelin receptor antagonists ambrisentan, bosentan, macitentan, and sitaxsentan as hepatobiliary transporter inhibitors and substrates in sandwich-cultured human hepatocytes.
    Lepist EI; Gillies H; Smith W; Hao J; Hubert C; St Claire RL; Brouwer KR; Ray AS
    PLoS One; 2014; 9(1):e87548. PubMed ID: 24498134
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Evaluation of the endothelin receptor antagonists ambrisentan, darusentan, bosentan, and sitaxsentan as substrates and inhibitors of hepatobiliary transporters in sandwich-cultured human hepatocytes.
    Hartman JC; Brouwer K; Mandagere A; Melvin L; Gorczynski R
    Can J Physiol Pharmacol; 2010 Jun; 88(6):682-91. PubMed ID: 20628435
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Macitentan does not interfere with hepatic bile salt transport.
    Treiber A; Äänismaa P; de Kanter R; Delahaye S; Treher M; Hess P; Sidharta P
    J Pharmacol Exp Ther; 2014 Jul; 350(1):130-43. PubMed ID: 24769543
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor.
    Yamada A; Maeda K; Kamiyama E; Sugiyama D; Kondo T; Shiroyanagi Y; Nakazawa H; Okano T; Adachi M; Schuetz JD; Adachi Y; Hu Z; Kusuhara H; Sugiyama Y
    Drug Metab Dispos; 2007 Dec; 35(12):2166-76. PubMed ID: 17823233
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Expression and localization of hepatobiliary transport proteins in progressive familial intrahepatic cholestasis.
    Keitel V; Burdelski M; Warskulat U; Kühlkamp T; Keppler D; Häussinger D; Kubitz R
    Hepatology; 2005 May; 41(5):1160-72. PubMed ID: 15841457
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Regulation of human hepatic drug transporter activity and expression by diesel exhaust particle extract.
    Le Vee M; Jouan E; Stieger B; Lecureur V; Fardel O
    PLoS One; 2015; 10(3):e0121232. PubMed ID: 25803276
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Optimized Hepatocyte-Like Cells with Functional Drug Transporters Directly-Reprogrammed from Mouse Fibroblasts and their Potential in Drug Disposition and Toxicology.
    Wu ZT; Yao D; Ji SY; Ni X; Gao YM; Hui LJ; Pan GY
    Cell Physiol Biochem; 2016; 38(5):1815-30. PubMed ID: 27160211
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Effect of phenobarbital on the expression of bile salt and organic anion transporters of rat liver.
    Hagenbuch N; Reichel C; Stieger B; Cattori V; Fattinger KE; Landmann L; Meier PJ; Kullak-Ublick GA
    J Hepatol; 2001 Jun; 34(6):881-7. PubMed ID: 11451172
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Differential inhibition of rat and human Na+-dependent taurocholate cotransporting polypeptide (NTCP/SLC10A1)by bosentan: a mechanism for species differences in hepatotoxicity.
    Leslie EM; Watkins PB; Kim RB; Brouwer KL
    J Pharmacol Exp Ther; 2007 Jun; 321(3):1170-8. PubMed ID: 17374746
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Slow receptor dissociation kinetics differentiate macitentan from other endothelin receptor antagonists in pulmonary arterial smooth muscle cells.
    Gatfield J; Mueller Grandjean C; Sasse T; Clozel M; Nayler O
    PLoS One; 2012; 7(10):e47662. PubMed ID: 23077657
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Fasiglifam (TAK-875) Inhibits Hepatobiliary Transporters: A Possible Factor Contributing to Fasiglifam-Induced Liver Injury.
    Li X; Zhong K; Guo Z; Zhong D; Chen X
    Drug Metab Dispos; 2015 Nov; 43(11):1751-9. PubMed ID: 26276582
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Interaction of digitalis-like compounds with liver uptake transporters NTCP, OATP1B1, and OATP1B3.
    Gozalpour E; Greupink R; Wortelboer HM; Bilos A; Schreurs M; Russel FG; Koenderink JB
    Mol Pharm; 2014 Jun; 11(6):1844-55. PubMed ID: 24754247
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The hepatobiliary disposition of timosaponin b2 is highly dependent on influx/efflux transporters but not metabolism.
    Sheng J; Tian X; Xu G; Wu Z; Chen C; Wang L; Pan L; Huang C; Pan G
    Drug Metab Dispos; 2015 Jan; 43(1):63-72. PubMed ID: 25336752
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Role of hepatic transporters in the disposition and hepatotoxicity of a HER2 tyrosine kinase inhibitor CP-724,714.
    Feng B; Xu JJ; Bi YA; Mireles R; Davidson R; Duignan DB; Campbell S; Kostrubsky VE; Dunn MC; Smith AR; Wang HF
    Toxicol Sci; 2009 Apr; 108(2):492-500. PubMed ID: 19223659
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Transporter studies with the 3-O-sulfate conjugate of 17alpha-ethinylestradiol: assessment of human liver drug transporters.
    Han YH; Busler D; Hong Y; Tian Y; Chen C; Rodrigues AD
    Drug Metab Dispos; 2010 Jul; 38(7):1072-82. PubMed ID: 20360302
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice.
    Kok T; Bloks VW; Wolters H; Havinga R; Jansen PL; Staels B; Kuipers F
    Biochem J; 2003 Feb; 369(Pt 3):539-47. PubMed ID: 12381268
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Molecular mechanisms governing different pharmacokinetics of ginsenosides and potential for ginsenoside-perpetrated herb-drug interactions on OATP1B3.
    Jiang R; Dong J; Li X; Du F; Jia W; Xu F; Wang F; Yang J; Niu W; Li C
    Br J Pharmacol; 2015 Feb; 172(4):1059-73. PubMed ID: 25297453
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Involvement of transporters in the hepatic uptake and biliary excretion of valsartan, a selective antagonist of the angiotensin II AT1-receptor, in humans.
    Yamashiro W; Maeda K; Hirouchi M; Adachi Y; Hu Z; Sugiyama Y
    Drug Metab Dispos; 2006 Jul; 34(7):1247-54. PubMed ID: 16624871
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The role of the sodium-taurocholate cotransporting polypeptide (NTCP) and of the bile salt export pump (BSEP) in physiology and pathophysiology of bile formation.
    Stieger B
    Handb Exp Pharmacol; 2011; (201):205-59. PubMed ID: 21103971
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Multiple compound-related adverse properties contribute to liver injury caused by endothelin receptor antagonists.
    Kenna JG; Stahl SH; Eakins JA; Foster AJ; Andersson LC; Bergare J; Billger M; Elebring M; Elmore CS; Thompson RA
    J Pharmacol Exp Ther; 2015 Feb; 352(2):281-90. PubMed ID: 25467130
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 28.