426 related articles for article (PubMed ID: 2449950)
1. Cytotoxicity, uptake, polyglutamate formation, and antileukemic effects of 8-deaza analogues of methotrexate and aminopterin in mice.
Kuehl M; Brixner DI; Broom AD; Avery TL; Blakley RL
Cancer Res; 1988 Mar; 48(6):1481-8. PubMed ID: 2449950
[TBL] [Abstract][Full Text] [Related]
2. Biochemical and growth inhibition studies of methotrexate and aminopterin analogues containing a tetrazole ring in place of the gamma-carboxyl group.
McGuire JJ; Russell CA; Bolanowska WE; Freitag CM; Jones CS; Kalman TI
Cancer Res; 1990 Mar; 50(6):1726-31. PubMed ID: 2306727
[TBL] [Abstract][Full Text] [Related]
3. Similar differential for total polyglutamylation and cytotoxicity among various folate analogues in human and murine tumor cells in vitro.
Samuels LL; Moccio DM; Sirotnak FM
Cancer Res; 1985 Apr; 45(4):1488-95. PubMed ID: 3978616
[TBL] [Abstract][Full Text] [Related]
4. Intracellular pharmacokinetics of methotrexate polyglutamates in human breast cancer cells. Selective retention and less dissociable binding of 4-NH2-10-CH3-pteroylglutamate4 and 4-NH2-10-CH3-pteroylglutamate5 to dihydrofolate reductase.
Jolivet J; Chabner BA
J Clin Invest; 1983 Sep; 72(3):773-8. PubMed ID: 6193143
[TBL] [Abstract][Full Text] [Related]
5. Prevention of methotrexate cytotoxicity by asparaginase inhibition of methotrexate polyglutamate formation.
Jolivet J; Cole DE; Holcenberg JS; Poplack DG
Cancer Res; 1985 Jan; 45(1):217-20. PubMed ID: 2578094
[TBL] [Abstract][Full Text] [Related]
6. Role of methotrexate polyglutamates in methotrexate- and sequential methotrexate-5-fluorouracil-mediated cell kill.
McGuire JJ; Mini E; Hsieh P; Bertino JR
Cancer Res; 1985 Dec; 45(12 Pt 1):6395-400. PubMed ID: 2415244
[TBL] [Abstract][Full Text] [Related]
7. Syntheses and antifolate activity of 5-methyl-5-deaza analogues of aminopterin, methotrexate, folic acid, and N10-methylfolic acid.
Piper JR; McCaleb GS; Montgomery JA; Kisliuk RL; Gaumont Y; Sirotnak FM
J Med Chem; 1986 Jun; 29(6):1080-7. PubMed ID: 2423690
[TBL] [Abstract][Full Text] [Related]
8. A new analogue of 10-deazaaminopterin with markedly enhanced curative effects against human tumor xenografts in mice.
Sirotnak FM; DeGraw JI; Colwell WT; Piper JR
Cancer Chemother Pharmacol; 1998; 42(4):313-8. PubMed ID: 9744777
[TBL] [Abstract][Full Text] [Related]
9. Enhanced polyglutamylation of aminopterin relative to methotrexate in the Ehrlich ascites tumor cell in vitro.
Matherly LH; Voss MK; Anderson LA; Fry DW; Goldman ID
Cancer Res; 1985 Mar; 45(3):1073-8. PubMed ID: 2578870
[TBL] [Abstract][Full Text] [Related]
10. Methotrexate analogues. 34. Replacement of the glutamate moiety in methotrexate and aminopterin by long-chain 2-aminoalkanedioic acids.
Rosowsky A; Bader H; Kohler W; Freisheim JH; Moran RG
J Med Chem; 1988 Jul; 31(7):1338-44. PubMed ID: 2898531
[TBL] [Abstract][Full Text] [Related]
11. Synthesis and in vitro antifolate activity of rotationally restricted aminopterin and methotrexate analogues.
Rosowsky A; Forsch RA; Wright JE
J Med Chem; 2004 Dec; 47(27):6958-63. PubMed ID: 15615544
[TBL] [Abstract][Full Text] [Related]
12. Novel 6,5-fused ring heterocyclic antifolates: biochemical and biological characterization.
McGuire JJ; Bergoltz VV; Heitzman KJ; Haile WH; Russell CA; Bolanowska WE; Kotake Y; Haneda T; Nomura H
Cancer Res; 1994 May; 54(10):2673-9. PubMed ID: 8168096
[TBL] [Abstract][Full Text] [Related]
13. Polyglutamylation of the dihydrofolate reductase inhibitor gamma-methylene-10-deazaaminopterin is not essential for antitumor activity.
Cao S; Abraham A; Nair MG; Pati R; Galivan JH; Hausheer FH; Rustum YM
Clin Cancer Res; 1996 Apr; 2(4):707-12. PubMed ID: 9816221
[TBL] [Abstract][Full Text] [Related]
14. Synthesis of methotrexate polyglutamates in L1210 murine leukemia cells.
Whitehead VM
Cancer Res; 1977 Feb; 37(2):408-12. PubMed ID: 832265
[TBL] [Abstract][Full Text] [Related]
15. Biochemical studies on PT523, a potent nonpolyglutamatable antifolate, in cultured cells.
Rhee MS; Galivan J; Wright JE; Rosowsky A
Mol Pharmacol; 1994 Apr; 45(4):783-91. PubMed ID: 7514264
[TBL] [Abstract][Full Text] [Related]
16. Structural design, biochemical properties, and evidence for improved therapeutic activity of 5-alkyl derivatives of 5-deazaaminopterin and 5-deazamethotrexate compared to methotrexate in murine tumor models.
Sirotnak FM; Schmid FA; Otter GM; Piper JR; Montgomery JA
Cancer Res; 1988 Oct; 48(20):5686-91. PubMed ID: 3167828
[TBL] [Abstract][Full Text] [Related]
17. Further evidence for a basis of selective activity and relative responsiveness during antifolate therapy of murine tumors.
Sirotnak FM; Donsback RC
Cancer Res; 1975 Jul; 35(7):1737-44. PubMed ID: 1169115
[TBL] [Abstract][Full Text] [Related]
18. Impact of polyglutamation on sensitivity to raltitrexed and methotrexate in relation to drug-induced inhibition of de novo thymidylate and purine biosynthesis in CCRF-CEM cell lines.
Barnes MJ; Estlin EJ; Taylor GA; Aherne GW; Hardcastle A; McGuire JJ; Calvete JA; Lunec J; Pearson AD; Newell DR
Clin Cancer Res; 1999 Sep; 5(9):2548-58. PubMed ID: 10499632
[TBL] [Abstract][Full Text] [Related]
19. Mechanisms of sensitivity and natural resistance to antifolates in a methylcholanthrene-induced rat sarcoma.
Li WW; Lin JT; Schweitzer BI; Bertino JR
Mol Pharmacol; 1991 Nov; 40(5):854-8. PubMed ID: 1719370
[TBL] [Abstract][Full Text] [Related]
20. Impaired polyglutamylation of methotrexate as a cause of resistance in CCRF-CEM cells after short-term, high-dose treatment with this drug.
Pizzorno G; Mini E; Coronnello M; McGuire JJ; Moroson BA; Cashmore AR; Dreyer RN; Lin JT; Mazzei T; Periti P
Cancer Res; 1988 Apr; 48(8):2149-55. PubMed ID: 2450647
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]