426 related articles for article (PubMed ID: 2449950)
21. Formation of methotrexate polyglutamates in purified myeloid precursor cells from normal human bone marrow.
Koizumi S; Curt GA; Fine RL; Griffin JD; Chabner BA
J Clin Invest; 1985 Mar; 75(3):1008-14. PubMed ID: 2579975
[TBL] [Abstract][Full Text] [Related]
22. 10-Ethyl-10-deaza-aminopterin: structural design and biochemical, pharmacologic, and antitumor properties.
Sirotnak FM; Schmid FA; Samuels LL; DeGraw JI
NCI Monogr; 1987; (5):127-31. PubMed ID: 2448650
[TBL] [Abstract][Full Text] [Related]
23. Synthesis and potent antifolate activity and cytotoxicity of B-ring deaza analogues of the nonpolyglutamatable dihydrofolate reductase inhibitor Nalpha-(4-amino-4-deoxypteroyl)-Ndelta-hemiphthaloyl- L-ornithine (PT523).
Rosowsky A; Wright JE; Vaidya CM; Bader H; Forsch RA; Mota CE; Pardo J; Chen CS; Chen YN
J Med Chem; 1998 Dec; 41(26):5310-9. PubMed ID: 9857098
[TBL] [Abstract][Full Text] [Related]
24. Methotrexate analogues. 19. Replacement of the glutamate side chain in classical antifolates by L-homocysteic acid and L-cysteic acid: effect on enzyme inhibition and antitumor activity.
Rosowsky A; Forsch RA; Freisheim JH; Moran RG; Wick M
J Med Chem; 1984 May; 27(5):600-4. PubMed ID: 6546949
[TBL] [Abstract][Full Text] [Related]
25. Analysis of "early" thymidine/inosine protection as an adjunct to methotrexate therapy.
Eleff M; Franks PE; Wampler GL; Collins JM; Goldman ID
Cancer Treat Rep; 1985; 69(7-8):867-74. PubMed ID: 2410122
[TBL] [Abstract][Full Text] [Related]
26. Combination chemotherapy with a new folate analog: activity of 10-ethyl-10-deaza-aminopterin compared to methotrexate with 5-fluorouracil and alkylating agents against advanced metastatic disease in murine tumor models.
Schmid FA; Sirotnak FM; Otter GM; DeGraw JI
Cancer Treat Rep; 1987; 71(7-8):727-32. PubMed ID: 3607784
[TBL] [Abstract][Full Text] [Related]
27. Hydroxylation of 4-amino-antifolates by partially purified aldehyde oxidase from rabbit liver.
Fabre G; Seither R; Goldman ID
Biochem Pharmacol; 1986 Apr; 35(8):1325-30. PubMed ID: 2421732
[TBL] [Abstract][Full Text] [Related]
28. Polyglutamylation, an important element in methotrexate cytotoxicity and selectivity in tumor versus murine granulocytic progenitor cells in vitro.
Fabre I; Fabre G; Goldman ID
Cancer Res; 1984 Aug; 44(8):3190-5. PubMed ID: 6204743
[TBL] [Abstract][Full Text] [Related]
29. Determinants of the disparate antitumor activities of (6R)-5,10-dideaza-5,6,7,8-tetrahydrofolate and methotrexate toward human lymphoblastic leukemia cells, characterized by severely impaired antifolate membrane transport.
Matherly LH; Angeles SM; McGuire JJ
Biochem Pharmacol; 1993 Dec; 46(12):2185-95. PubMed ID: 7506026
[TBL] [Abstract][Full Text] [Related]
30. Establishment of methotrexate-resistant human acute lymphoblastic leukemia cells in culture and effects of folate antagonists.
Ohnoshi T; Ohnuma T; Takahashi I; Scanlon K; Kamen BA; Holland JF
Cancer Res; 1982 May; 42(5):1655-60. PubMed ID: 6978176
[TBL] [Abstract][Full Text] [Related]
31. Formation of methotrexate polyglutamates in rat hepatocytes.
Gewirtz DA; White JC; Randolph JK; Goldman ID
Cancer Res; 1979 Aug; 39(8):2914-8. PubMed ID: 455278
[TBL] [Abstract][Full Text] [Related]
32. Dihydrofolate reductase binding and cellular uptake of nonpolyglutamatable antifolates: correlates of cytotoxicity toward methotrexate-sensitive and -resistant human head and neck squamous carcinoma cells.
Chen G; Wright JE; Rosowsky A
Mol Pharmacol; 1995 Oct; 48(4):758-65. PubMed ID: 7476904
[TBL] [Abstract][Full Text] [Related]
33. Biochemical and growth inhibitory effects of the erythro and threo isomers of gamma-fluoromethotrexate, a methotrexate analogue defective in polyglutamylation.
McGuire JJ; Graber M; Licato N; Vincenz C; Coward JK; Nimec Z; Galivan J
Cancer Res; 1989 Aug; 49(16):4517-25. PubMed ID: 2472880
[TBL] [Abstract][Full Text] [Related]
34. Role of polyglutamates in methotrexate action.
Wilmanns W; Schalhorn A
Chemioterapia; 1985 Oct; 4(5):349-53. PubMed ID: 2416481
[TBL] [Abstract][Full Text] [Related]
35. Inherent resistance of human squamous carcinoma cell lines to methotrexate as a result of decreased polyglutamylation of this drug.
Pizzorno G; Chang YM; McGuire JJ; Bertino JR
Cancer Res; 1989 Oct; 49(19):5275-80. PubMed ID: 2475246
[TBL] [Abstract][Full Text] [Related]
36. Folate analogues as substrates of mammalian folylpolyglutamate synthetase.
Schoo MM; Pristupa ZB; Vickers PJ; Scrimgeour KG
Cancer Res; 1985 Jul; 45(7):3034-41. PubMed ID: 3873989
[TBL] [Abstract][Full Text] [Related]
37. Interaction of polyglutamyl derivatives of methotrexate, 10-deazaaminopterin, and dihydrofolate with dihydrofolate reductase.
Kumar P; Kisliuk RL; Gaumont Y; Nair MG; Baugh CM; Kaufman BT
Cancer Res; 1986 Oct; 46(10):5020-3. PubMed ID: 2428470
[TBL] [Abstract][Full Text] [Related]
38. Studies on analogues of classical antifolates bearing the naphthoyl group in place of benzoyl in the side chain.
Piper JR; Johnson CA; Maddry JA; Malik ND; McGuire JJ; Otter GM; Sirotnak FM
J Med Chem; 1993 Dec; 36(26):4161-71. PubMed ID: 8277497
[TBL] [Abstract][Full Text] [Related]
39. Methotrexate analogues. 26. Inhibition of dihydrofolate reductase and folylpolyglutamate synthetase activity and in vitro tumor cell growth by methotrexate and aminopterin analogues containing a basic amino acid side chain.
Rosowsky A; Freisheim JH; Moran RG; Solan VC; Bader H; Wright JE; Radike-Smith M
J Med Chem; 1986 May; 29(5):655-60. PubMed ID: 2871191
[TBL] [Abstract][Full Text] [Related]
40. Proliferation-dependent cytotoxicity of methotrexate in murine L5178Y leukemia.
Fernandes DJ; Sur P; Kute TE; Capizzi RL
Cancer Res; 1988 Oct; 48(20):5638-44. PubMed ID: 2458828
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]