These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

97 related articles for article (PubMed ID: 2451526)

  • 21. Biochemical studies on PT523, a potent nonpolyglutamatable antifolate, in cultured cells.
    Rhee MS; Galivan J; Wright JE; Rosowsky A
    Mol Pharmacol; 1994 Apr; 45(4):783-91. PubMed ID: 7514264
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Cytotoxicity of antifolate inhibitors of thymidylate and purine synthesis to WiDr colonic carcinoma cells.
    Smith SG; Lehman NL; Moran RG
    Cancer Res; 1993 Dec; 53(23):5697-706. PubMed ID: 8242626
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Antitumor activity of antifolate inhibitors of thymidylate and purine synthesis in human soft tissue sarcoma cell lines with intrinsic resistance to methotrexate.
    Li WW; Tong WP; Bertino JR
    Clin Cancer Res; 1995 Jun; 1(6):631-6. PubMed ID: 9816025
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Biochemical and cellular pharmacology of 1843U89, a novel benzoquinazoline inhibitor of thymidylate synthase.
    Duch DS; Banks S; Dev IK; Dickerson SH; Ferone R; Heath LS; Humphreys J; Knick V; Pendergast W; Singer S
    Cancer Res; 1993 Feb; 53(4):810-8. PubMed ID: 8428362
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Biological activity and intracellular metabolism of ZD1694 in human leukemia cell lines with different resistance mechanisms to antifolate drugs.
    Takemura Y; Kobayashi H; Miyachi H; Gibson W; Kimbell R; Jackman AL
    Jpn J Cancer Res; 1996 Jul; 87(7):773-80. PubMed ID: 8698629
    [TBL] [Abstract][Full Text] [Related]  

  • 26. The reduced folate/methotrexate carrier and a membrane-associated folate binding protein as transport routes for novel antifolates: structure-activity relationships.
    Jansen G; Westerhof GR; Schornagel JH; Jackman AL; Boyle FT
    Adv Exp Med Biol; 1993; 338():767-70. PubMed ID: 8304225
    [No Abstract]   [Full Text] [Related]  

  • 27. Biological activity of the multitargeted antifolate, MTA (LY231514), in human cell lines with different resistance mechanisms to antifolate drugs.
    Schultz RM; Chen VJ; Bewley JR; Roberts EF; Shih C; Dempsey JA
    Semin Oncol; 1999 Apr; 26(2 Suppl 6):68-73. PubMed ID: 10598558
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Cytotoxicity, uptake, polyglutamate formation, and antileukemic effects of 8-deaza analogues of methotrexate and aminopterin in mice.
    Kuehl M; Brixner DI; Broom AD; Avery TL; Blakley RL
    Cancer Res; 1988 Mar; 48(6):1481-8. PubMed ID: 2449950
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Dissociation of thymidylate biosynthesis from DNA biosynthesis by 5-fluoro-2'-deoxyuridine and 5,8-dideazaisofolic acid.
    Fernandes DJ; Cranford SK
    Cancer Res; 1986 Apr; 46(4 Pt 1):1741-7. PubMed ID: 2936450
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Determinants of the disparate antitumor activities of (6R)-5,10-dideaza-5,6,7,8-tetrahydrofolate and methotrexate toward human lymphoblastic leukemia cells, characterized by severely impaired antifolate membrane transport.
    Matherly LH; Angeles SM; McGuire JJ
    Biochem Pharmacol; 1993 Dec; 46(12):2185-95. PubMed ID: 7506026
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Biochemical and biological studies on 2-desamino-2-methylaminopterin, an antifolate the polyglutamates of which are more potent than the monoglutamate against three key enzymes of folate metabolism.
    Rosowsky A; Galivan J; Beardsley GP; Bader H; O'Connor BM; Russello O; Moroson BA; DeYarman MT; Kerwar SS; Freisheim JH
    Cancer Res; 1992 Apr; 52(8):2148-55. PubMed ID: 1313737
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Intracellular metabolism of 5-formyl tetrahydrofolate in human breast and colon cell lines.
    Boarman DM; Allegra CJ
    Cancer Res; 1992 Jan; 52(1):36-44. PubMed ID: 1370075
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Formation and retention and biological activity of N10-propargyl-5,8-dideazafolic acid (CB3717) polyglutamates in L1210 cells in vitro.
    Sikora E; Jackman AL; Newell DR; Calvert AH
    Biochem Pharmacol; 1988 Nov; 37(21):4047-54. PubMed ID: 2461200
    [TBL] [Abstract][Full Text] [Related]  

  • 34. N10-propargyl-5,8-dideazafolic acid (CB3717): inhibitory effects on human leukemia cell lines resistant to methotrexate or trimetrexate.
    Takemura Y; Ohnuma T
    Mt Sinai J Med; 1992 Oct; 59(5):419-24. PubMed ID: 1435841
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Metabolism of the diaminoantifolates: biosynthesis and pharmacology of the 7-hydroxyl and polyglutamyl metabolites of methotrexate and related antifolates.
    Matherly LH; Seither RL; Goldman ID
    Pharmacol Ther; 1987; 35(1-2):27-56. PubMed ID: 2447596
    [No Abstract]   [Full Text] [Related]  

  • 36. Effects of 5,8-dideazaisopteroylglutamate (IAHQ) on L1210 leukemia in mice when given alone and in combination with methotrexate, probenecid, or verapamil.
    Hynes JB; Smith AB; Gale GR
    Cancer Chemother Pharmacol; 1986; 18(3):231-4. PubMed ID: 3802378
    [TBL] [Abstract][Full Text] [Related]  

  • 37. 5-fluorouracil-methotrexate synergy: enhancement of 5-fluorodeoxyridylate binding to thymidylate synthase by dihydropteroylpolyglutamates.
    Fernandes DJ; Bertino JR
    Proc Natl Acad Sci U S A; 1980 Oct; 77(10):5663-7. PubMed ID: 6160578
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as dual inhibitors of dihydrofolate reductase and thymidylate synthase and as potential antitumor agents.
    Gangjee A; Lin X; Kisliuk RL; McGuire JJ
    J Med Chem; 2005 Nov; 48(23):7215-22. PubMed ID: 16279780
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Dihydrofolate reductase binding and cellular uptake of nonpolyglutamatable antifolates: correlates of cytotoxicity toward methotrexate-sensitive and -resistant human head and neck squamous carcinoma cells.
    Chen G; Wright JE; Rosowsky A
    Mol Pharmacol; 1995 Oct; 48(4):758-65. PubMed ID: 7476904
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Biochemical and antitumor effects of 5,8-dideazaisopteroylglutamate, a unique quinazoline inhibitor of thymidylate synthase.
    Fernandes DJ; Bertino JR; Hynes JB
    Cancer Res; 1983 Mar; 43(3):1117-23. PubMed ID: 6825083
    [No Abstract]   [Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 5.