268 related articles for article (PubMed ID: 24521431)
1. Potent and selective small-molecule inhibitors of cIAP1/2 proteins reveal that the binding of Smac mimetics to XIAP BIR3 is not required for their effective induction of cell death in tumor cells.
Sun H; Lu J; Liu L; Yang CY; Wang S
ACS Chem Biol; 2014 Apr; 9(4):994-1002. PubMed ID: 24521431
[TBL] [Abstract][Full Text] [Related]
2. Structure-based design and molecular profiling of Smac-mimetics selective for cellular IAPs.
Corti A; Milani M; Lecis D; Seneci P; de Rosa M; Mastrangelo E; Cossu F
FEBS J; 2018 Sep; 285(17):3286-3298. PubMed ID: 30055105
[TBL] [Abstract][Full Text] [Related]
3. Design of small-molecule Smac mimetics as IAP antagonists.
Wang S
Curr Top Microbiol Immunol; 2011; 348():89-113. PubMed ID: 21072626
[TBL] [Abstract][Full Text] [Related]
4. ASTX660, a Novel Non-peptidomimetic Antagonist of cIAP1/2 and XIAP, Potently Induces TNFα-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor Growth.
Ward GA; Lewis EJ; Ahn JS; Johnson CN; Lyons JF; Martins V; Munck JM; Rich SJ; Smyth T; Thompson NT; Williams PA; Wilsher NE; Wallis NG; Chessari G
Mol Cancer Ther; 2018 Jul; 17(7):1381-1391. PubMed ID: 29695633
[TBL] [Abstract][Full Text] [Related]
5. Small-molecule SMAC mimetics as new cancer therapeutics.
Bai L; Smith DC; Wang S
Pharmacol Ther; 2014 Oct; 144(1):82-95. PubMed ID: 24841289
[TBL] [Abstract][Full Text] [Related]
6. Structural insight into inhibitor of apoptosis proteins recognition by a potent divalent smac-mimetic.
Cossu F; Milani M; Vachette P; Malvezzi F; Grassi S; Lecis D; Delia D; Drago C; Seneci P; Bolognesi M; Mastrangelo E
PLoS One; 2012; 7(11):e49527. PubMed ID: 23166698
[TBL] [Abstract][Full Text] [Related]
7. Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2.
Cossu F; Mastrangelo E; Milani M; Sorrentino G; Lecis D; Delia D; Manzoni L; Seneci P; Scolastico C; Bolognesi M
Biochem Biophys Res Commun; 2009 Jan; 378(2):162-7. PubMed ID: 18992220
[TBL] [Abstract][Full Text] [Related]
8. Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.
Zobel K; Wang L; Varfolomeev E; Franklin MC; Elliott LO; Wallweber HJ; Okawa DC; Flygare JA; Vucic D; Fairbrother WJ; Deshayes K
ACS Chem Biol; 2006 Sep; 1(8):525-33. PubMed ID: 17168540
[TBL] [Abstract][Full Text] [Related]
9. Structural basis for bivalent Smac-mimetics recognition in the IAP protein family.
Cossu F; Milani M; Mastrangelo E; Vachette P; Servida F; Lecis D; Canevari G; Delia D; Drago C; Rizzo V; Manzoni L; Seneci P; Scolastico C; Bolognesi M
J Mol Biol; 2009 Sep; 392(3):630-44. PubMed ID: 19393243
[TBL] [Abstract][Full Text] [Related]
10. Optimization of benzodiazepinones as selective inhibitors of the X-linked inhibitor of apoptosis protein (XIAP) second baculovirus IAP repeat (BIR2) domain.
Kester RF; Donnell AF; Lou Y; Remiszewski SW; Lombardo LJ; Chen S; Le NT; Lo J; Moliterni JA; Han X; Hogg JH; Liang W; Michoud C; Rupert KC; Mischke S; Le K; Weisel M; Janson CA; Lukacs CM; Fretland AJ; Hong K; Polonskaia A; Gao L; Li S; Solis DS; Aguilar D; Tardell C; Dvorozniak M; Tannu S; Lee EC; Schutt AD; Goggin B
J Med Chem; 2013 Oct; 56(20):7788-803. PubMed ID: 24093940
[TBL] [Abstract][Full Text] [Related]
11. Cyclopeptide Smac mimetics as antagonists of IAP proteins.
Sun H; Liu L; Lu J; Qiu S; Yang CY; Yi H; Wang S
Bioorg Med Chem Lett; 2010 May; 20(10):3043-6. PubMed ID: 20443226
[TBL] [Abstract][Full Text] [Related]
12. Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis.
Welsh K; Milutinovic S; Ardecky RJ; Gonzalez-Lopez M; Ganji SR; Teriete P; Finlay D; Riedl S; Matsuzawa S; Pinilla C; Houghten R; Vuori K; Reed JC; Cosford ND
PLoS One; 2016; 11(9):e0161952. PubMed ID: 27617834
[TBL] [Abstract][Full Text] [Related]
13. Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles.
Mastrangelo E; Cossu F; Milani M; Sorrentino G; Lecis D; Delia D; Manzoni L; Drago C; Seneci P; Scolastico C; Rizzo V; Bolognesi M
J Mol Biol; 2008 Dec; 384(3):673-89. PubMed ID: 18851976
[TBL] [Abstract][Full Text] [Related]
14. Bivalent Smac mimetics with a diazabicyclic core as highly potent antagonists of XIAP and cIAP1/2 and novel anticancer agents.
Peng Y; Sun H; Lu J; Liu L; Cai Q; Shen R; Yang CY; Yi H; Wang S
J Med Chem; 2012 Jan; 55(1):106-14. PubMed ID: 22148838
[TBL] [Abstract][Full Text] [Related]
15. Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity.
Sun H; Liu L; Lu J; Bai L; Li X; Nikolovska-Coleska Z; McEachern D; Yang CY; Qiu S; Yi H; Sun D; Wang S
J Med Chem; 2011 May; 54(9):3306-18. PubMed ID: 21462933
[TBL] [Abstract][Full Text] [Related]
16. Benzazepinones and benzoxazepinones as antagonists of inhibitor of apoptosis proteins (IAPs) selective for the second baculovirus IAP repeat (BIR2) domain.
Donnell AF; Michoud C; Rupert KC; Han X; Aguilar D; Frank KB; Fretland AJ; Gao L; Goggin B; Hogg JH; Hong K; Janson CA; Kester RF; Kong N; Le K; Li S; Liang W; Lombardo LJ; Lou Y; Lukacs CM; Mischke S; Moliterni JA; Polonskaia A; Schutt AD; Solis DS; Specian A; Taylor RT; Weisel M; Remiszewski SW
J Med Chem; 2013 Oct; 56(20):7772-87. PubMed ID: 24083782
[TBL] [Abstract][Full Text] [Related]
17. Small-molecule IAP antagonists sensitize cancer cells to TRAIL-induced apoptosis: roles of XIAP and cIAPs.
Finlay D; Vamos M; González-López M; Ardecky RJ; Ganji SR; Yuan H; Su Y; Cooley TR; Hauser CT; Welsh K; Reed JC; Cosford ND; Vuori K
Mol Cancer Ther; 2014 Jan; 13(1):5-15. PubMed ID: 24194568
[TBL] [Abstract][Full Text] [Related]
18. Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins.
Sun H; Lu J; Liu L; Yi H; Qiu S; Yang CY; Deschamps JR; Wang S
J Med Chem; 2010 Sep; 53(17):6361-7. PubMed ID: 20684551
[TBL] [Abstract][Full Text] [Related]
19. Recognition of Smac-mimetic compounds by the BIR domain of cIAP1.
Cossu F; Malvezzi F; Canevari G; Mastrangelo E; Lecis D; Delia D; Seneci P; Scolastico C; Bolognesi M; Milani M
Protein Sci; 2010 Dec; 19(12):2418-29. PubMed ID: 20954235
[TBL] [Abstract][Full Text] [Related]
20. Smac mimetics in combination with TRAIL selectively target cancer stem cells in nasopharyngeal carcinoma.
Wu MS; Wang GF; Zhao ZQ; Liang Y; Wang HB; Wu MY; Min P; Chen LZ; Feng QS; Bei JX; Zeng YX; Yang D
Mol Cancer Ther; 2013 Sep; 12(9):1728-37. PubMed ID: 23699656
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]