BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

159 related articles for article (PubMed ID: 24532667)

  • 1. Humanizing mouse folate metabolism: conversion of the dual-promoter mouse folylpolyglutamate synthetase gene to the human single-promoter structure.
    Yang C; Xie LY; Windle JJ; Taylor SM; Moran RG
    FASEB J; 2014 May; 28(5):1998-2008. PubMed ID: 24532667
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Expression patterns of the multiple transcripts from the folylpolyglutamate synthetase gene in human leukemias and normal differentiated tissues.
    Turner FB; Taylor SM; Moran RG
    J Biol Chem; 2000 Nov; 275(46):35960-8. PubMed ID: 10964921
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Folylpoly-γ-glutamate synthetase: A key determinant of folate homeostasis and antifolate resistance in cancer.
    Raz S; Stark M; Assaraf YG
    Drug Resist Updat; 2016 Sep; 28():43-64. PubMed ID: 27620954
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines.
    Liani E; Rothem L; Bunni MA; Smith CA; Jansen G; Assaraf YG
    Int J Cancer; 2003 Feb; 103(5):587-99. PubMed ID: 12494465
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of antifolate resistance in leukemia.
    Stark M; Wichman C; Avivi I; Assaraf YG
    Blood; 2009 Apr; 113(18):4362-9. PubMed ID: 19131550
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Folylpoly-gamma-glutamate synthetase: generation of isozymes and the role in one carbon metabolism and antifolate cytotoxicity.
    Qi H; Atkinson I; Xiao S; Choi YJ; Tobimatsu T; Shane B
    Adv Enzyme Regul; 1999; 39():263-73. PubMed ID: 10470377
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Transcription of the human folylpoly-gamma-glutamate synthetase gene.
    Freemantle SJ; Moran RG
    J Biol Chem; 1997 Oct; 272(40):25373-9. PubMed ID: 9312158
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Regulation of folate and one-carbon metabolism in mammalian cells. I. Folate metabolism in Chinese hamster ovary cells expressing Escherichia coli or human folylpoly-gamma-glutamate synthetase activity.
    Osborne CB; Lowe KE; Shane B
    J Biol Chem; 1993 Oct; 268(29):21657-64. PubMed ID: 8408018
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Different antifolate-resistant L1210 cell variants with either increased or decreased folylpolyglutamate synthetase gene expression at the level of mRNA transcription.
    Roy K; Mitsugi K; Sirlin S; Shane B; Sirotnak FM
    J Biol Chem; 1995 Nov; 270(45):26918-22. PubMed ID: 7592937
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Additional organizational features of the murine folylpolyglutamate synthetase gene. Two remotely situated exons encoding an alternate 5' end and proximal open reading frame under the control of a second promoter.
    Roy K; Mitsugi K; Sirotnak FM
    J Biol Chem; 1997 Feb; 272(9):5587-93. PubMed ID: 9038166
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene.
    Chen L; Qi H; Korenberg J; Garrow TA; Choi YJ; Shane B
    J Biol Chem; 1996 May; 271(22):13077-87. PubMed ID: 8662720
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Regulation of folate and one-carbon metabolism in mammalian cells. II. Effect of folylpoly-gamma-glutamate synthetase substrate specificity and level on folate metabolism and folylpoly-gamma-glutamate specificity of metabolic cycles of one-carbon metabolism.
    Lowe KE; Osborne CB; Lin BF; Kim JS; Hsu JC; Shane B
    J Biol Chem; 1993 Oct; 268(29):21665-73. PubMed ID: 8408019
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Mouse folylpoly-gamma-glutamate synthetase isoforms respond differently to feedback inhibition by folylpolyglutamate cofactors.
    Andreassi JL; Moran RG
    Biochemistry; 2002 Jan; 41(1):226-35. PubMed ID: 11772020
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Binding of a Smad4/Ets-1 complex to a novel intragenic regulatory element in exon12 of FPGS underlies decreased gene expression and antifolate resistance in leukemia.
    Raz S; Stark M; Assaraf YG
    Oncotarget; 2014 Oct; 5(19):9183-98. PubMed ID: 25229333
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Dietary folate and folylpolyglutamate synthetase activity in normal and neoplastic murine tissues and human tumor xenografts.
    Gates SB; Worzalla JF; Shih C; Grindey GB; Mendelsohn LG
    Biochem Pharmacol; 1996 Nov; 52(9):1477-9. PubMed ID: 8937460
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mammalian mitochondrial and cytosolic folylpolyglutamate synthetase maintain the subcellular compartmentalization of folates.
    Lawrence SA; Titus SA; Ferguson J; Heineman AL; Taylor SM; Moran RG
    J Biol Chem; 2014 Oct; 289(42):29386-96. PubMed ID: 25164808
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Upstream organization of and multiple transcripts from the human folylpoly-gamma-glutamate synthetase gene.
    Freemantle SJ; Taylor SM; Krystal G; Moran RG
    J Biol Chem; 1995 Apr; 270(16):9579-84. PubMed ID: 7721888
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Analysis of folylpoly-gamma-glutamate synthetase gene expression in human B-precursor ALL and T-lineage ALL cells.
    Leclerc GJ; Leclerc GM; Kinser TT; Barredo JC
    BMC Cancer; 2006 May; 6():132. PubMed ID: 16707018
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Posttranscriptionally mediated decreases in folylpolyglutamate synthetase gene expression in some folate analogue-resistant variants of the L1210 cell. Evidence for an altered cognate mRNA in the variants affecting the rate of de novo synthesis of the enzyme.
    Roy K; Egan MG; Sirlin S; Sirotnak FM
    J Biol Chem; 1997 Mar; 272(11):6903-8. PubMed ID: 9054377
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A bifunctional dihydrofolate synthetase--folylpolyglutamate synthetase in Plasmodium falciparum identified by functional complementation in yeast and bacteria.
    Salcedo E; Cortese JF; Plowe CV; Sims PF; Hyde JE
    Mol Biochem Parasitol; 2001 Feb; 112(2):239-52. PubMed ID: 11223131
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.