BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

212 related articles for article (PubMed ID: 24567327)

  • 1. Molecular basis for preventing α-synuclein aggregation by a molecular tweezer.
    Acharya S; Safaie BM; Wongkongkathep P; Ivanova MI; Attar A; Klärner FG; Schrader T; Loo JA; Bitan G; Lapidus LJ
    J Biol Chem; 2014 Apr; 289(15):10727-10737. PubMed ID: 24567327
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Characterization of Molecular Tweezer Binding on α-Synuclein with Native Top-Down Mass Spectrometry and Ion Mobility-Mass Spectrometry Reveals a Mechanism for Aggregation Inhibition.
    Lantz C; Lopez J; Goring AK; Zenaidee MA; Biggs K; Whitelegge JP; Ogorzalek Loo RR; Klärner FG; Schrader T; Bitan G; Loo JA
    J Am Soc Mass Spectrom; 2023 Dec; 34(12):2739-2747. PubMed ID: 37936057
    [TBL] [Abstract][Full Text] [Related]  

  • 3. CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson's disease.
    Bengoa-Vergniory N; Faggiani E; Ramos-Gonzalez P; Kirkiz E; Connor-Robson N; Brown LV; Siddique I; Li Z; Vingill S; Cioroch M; Cavaliere F; Threlfell S; Roberts B; Schrader T; Klärner FG; Cragg S; Dehay B; Bitan G; Matute C; Bezard E; Wade-Martins R
    Nat Commun; 2020 Sep; 11(1):4885. PubMed ID: 32985503
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Native Top-Down Mass Spectrometry and Ion Mobility Spectrometry of the Interaction of Tau Protein with a Molecular Tweezer Assembly Modulator.
    Nshanian M; Lantz C; Wongkongkathep P; Schrader T; Klärner FG; Blümke A; Despres C; Ehrmann M; Smet-Nocca C; Bitan G; Loo JA
    J Am Soc Mass Spectrom; 2019 Jan; 30(1):16-23. PubMed ID: 30062477
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A Molecular Tweezer Ameliorates Motor Deficits in Mice Overexpressing α-Synuclein.
    Richter F; Subramaniam SR; Magen I; Lee P; Hayes J; Attar A; Zhu C; Franich NR; Bove N; De La Rosa K; Kwong J; Klärner FG; Schrader T; Chesselet MF; Bitan G
    Neurotherapeutics; 2017 Oct; 14(4):1107-1119. PubMed ID: 28585223
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Inhibition of Mutant αB Crystallin-Induced Protein Aggregation by a Molecular Tweezer.
    Xu N; Bitan G; Schrader T; Klärner FG; Osinska H; Robbins J
    J Am Heart Assoc; 2017 Aug; 6(8):. PubMed ID: 28862927
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins.
    Sinha S; Lopes DH; Du Z; Pang ES; Shanmugam A; Lomakin A; Talbiersky P; Tennstaedt A; McDaniel K; Bakshi R; Kuo PY; Ehrmann M; Benedek GB; Loo JA; Klärner FG; Schrader T; Wang C; Bitan G
    J Am Chem Soc; 2011 Oct; 133(42):16958-69. PubMed ID: 21916458
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The Lys-Specific Molecular Tweezer, CLR01, Modulates Aggregation of the Mutant p53 DNA Binding Domain and Inhibits Its Toxicity.
    Herzog G; Shmueli MD; Levy L; Engel L; Gazit E; Klärner FG; Schrader T; Bitan G; Segal D
    Biochemistry; 2015 Jun; 54(24):3729-38. PubMed ID: 26030124
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Aggregation of α-synuclein is kinetically controlled by intramolecular diffusion.
    Ahmad B; Chen Y; Lapidus LJ
    Proc Natl Acad Sci U S A; 2012 Feb; 109(7):2336-41. PubMed ID: 22308332
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Disaggregation mechanism of prion amyloid for tweezer inhibitor.
    Rahman MU; Rehman AU; Arshad T; Chen HF
    Int J Biol Macromol; 2021 Apr; 176():510-519. PubMed ID: 33607137
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Phosphorylation of α-Synuclein at Y125 and S129 alters its metal binding properties: implications for understanding the role of α-Synuclein in the pathogenesis of Parkinson's Disease and related disorders.
    Lu Y; Prudent M; Fauvet B; Lashuel HA; Girault HH
    ACS Chem Neurosci; 2011 Nov; 2(11):667-75. PubMed ID: 22860160
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01.
    Sinha S; Du Z; Maiti P; Klärner FG; Schrader T; Wang C; Bitan G
    ACS Chem Neurosci; 2012 Jun; 3(6):451-8. PubMed ID: 22860214
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synergistic Amyloid Switch Triggered by Early Heterotypic Oligomerization of Intrinsically Disordered α-Synuclein and Tau.
    Bhasne K; Sebastian S; Jain N; Mukhopadhyay S
    J Mol Biol; 2018 Aug; 430(16):2508-2520. PubMed ID: 29704492
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Mechanism of Inhibition of Beta Amyloid Toxicity by Supramolecular Tweezers.
    Mittal S; Bravo-Rodriguez K; Sanchez-Garcia E
    J Phys Chem B; 2018 Apr; 122(15):4196-4205. PubMed ID: 29630377
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Investigation of intramolecular dynamics and conformations of α-, β- and γ-synuclein.
    Ducas VC; Rhoades E
    PLoS One; 2014; 9(1):e86983. PubMed ID: 24489820
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Site-specific interactions of Cu(II) with alpha and beta-synuclein: bridging the molecular gap between metal binding and aggregation.
    Binolfi A; Lamberto GR; Duran R; Quintanar L; Bertoncini CW; Souza JM; Cerveñansky C; Zweckstetter M; Griesinger C; Fernández CO
    J Am Chem Soc; 2008 Sep; 130(35):11801-12. PubMed ID: 18693689
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The early events of alpha-synuclein oligomerization revealed by photo-induced cross-linking.
    Li HT; Lin XJ; Xie YY; Hu HY
    Protein Pept Lett; 2006; 13(4):385-90. PubMed ID: 16712515
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Curcumin prevents aggregation in α-synuclein by increasing reconfiguration rate.
    Ahmad B; Lapidus LJ
    J Biol Chem; 2012 Mar; 287(12):9193-9. PubMed ID: 22267729
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Effects of Mutations on the Reconfiguration Rate of α-Synuclein.
    Acharya S; Saha S; Ahmad B; Lapidus LJ
    J Phys Chem B; 2015 Dec; 119(50):15443-50. PubMed ID: 26572968
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The molecular tweezer CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophy.
    Herrera-Vaquero M; Bouquio D; Kallab M; Biggs K; Nair G; Ochoa J; Heras-Garvin A; Heid C; Hadrovic I; Poewe W; Wenning GK; Klärner FG; Schrader T; Bitan G; Stefanova N
    Biochim Biophys Acta Mol Basis Dis; 2019 Nov; 1865(11):165513. PubMed ID: 31319154
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.