212 related articles for article (PubMed ID: 24576605)
1. Antiparallel conformation of knob and hole aglycosylated half-antibody homodimers is mediated by a CH2-CH3 hydrophobic interaction.
Elliott JM; Ultsch M; Lee J; Tong R; Takeda K; Spiess C; Eigenbrot C; Scheer JM
J Mol Biol; 2014 May; 426(9):1947-57. PubMed ID: 24576605
[TBL] [Abstract][Full Text] [Related]
2. Structural differences between glycosylated, disulfide-linked heterodimeric Knob-into-Hole Fc fragment and its homodimeric Knob-Knob and Hole-Hole side products.
Kuglstatter A; Stihle M; Neumann C; Müller C; Schaefer W; Klein C; Benz J;
Protein Eng Des Sel; 2017 Sep; 30(9):649-656. PubMed ID: 28985438
[TBL] [Abstract][Full Text] [Related]
3. IgG2 Fc structure and the dynamic features of the IgG CH2-CH3 interface.
Teplyakov A; Zhao Y; Malia TJ; Obmolova G; Gilliland GL
Mol Immunol; 2013 Nov; 56(1-2):131-9. PubMed ID: 23628091
[TBL] [Abstract][Full Text] [Related]
4. Crystal structures of immunoglobulin Fc heterodimers reveal the molecular basis for heterodimer formation.
Choi HJ; Seok SH; Kim YJ; Seo MD; Kim YS
Mol Immunol; 2015 Jun; 65(2):377-83. PubMed ID: 25743157
[TBL] [Abstract][Full Text] [Related]
5. Immunoglobulin domain interface exchange as a platform technology for the generation of Fc heterodimers and bispecific antibodies.
Skegro D; Stutz C; Ollier R; Svensson E; Wassmann P; Bourquin F; Monney T; Gn S; Blein S
J Biol Chem; 2017 Jun; 292(23):9745-9759. PubMed ID: 28450393
[TBL] [Abstract][Full Text] [Related]
6. Structural and Functional Characterization of a Hole-Hole Homodimer Variant in a "Knob-Into-Hole" Bispecific Antibody.
Zhang HM; Li C; Lei M; Lundin V; Lee HY; Ninonuevo M; Lin K; Han G; Sandoval W; Lei D; Ren G; Zhang J; Liu H
Anal Chem; 2017 Dec; 89(24):13494-13501. PubMed ID: 29129068
[TBL] [Abstract][Full Text] [Related]
7. Single-Molecule 3D Images of "Hole-Hole" IgG1 Homodimers by Individual-Particle Electron Tomography.
Lei D; Liu J; Liu H; Cleveland TE; Marino JP; Lei M; Ren G
Sci Rep; 2019 Jun; 9(1):8864. PubMed ID: 31221961
[TBL] [Abstract][Full Text] [Related]
8. SEEDbodies: fusion proteins based on strand-exchange engineered domain (SEED) CH3 heterodimers in an Fc analogue platform for asymmetric binders or immunofusions and bispecific antibodies.
Davis JH; Aperlo C; Li Y; Kurosawa E; Lan Y; Lo KM; Huston JS
Protein Eng Des Sel; 2010 Apr; 23(4):195-202. PubMed ID: 20299542
[TBL] [Abstract][Full Text] [Related]
9. Engineering of Immunoglobulin Fc Heterodimers Using Yeast Surface-Displayed Combinatorial Fc Library Screening.
Choi HJ; Kim YJ; Choi DK; Kim YS
PLoS One; 2015; 10(12):e0145349. PubMed ID: 26675656
[TBL] [Abstract][Full Text] [Related]
10. Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Leaver-Fay A; Froning KJ; Atwell S; Aldaz H; Pustilnik A; Lu F; Huang F; Yuan R; Hassanali S; Chamberlain AK; Fitchett JR; Demarest SJ; Kuhlman B
Structure; 2016 Apr; 24(4):641-651. PubMed ID: 26996964
[TBL] [Abstract][Full Text] [Related]
11. Probing the Impact of the Knob-into-Hole Mutations on the Structure and Function of a Therapeutic Antibody.
Liu P; Gao X; Lundin V; Shi C; Adem Y; Lin K; Jiang G; Kao YH; Yang F; Michels D; Marshall AG; Zhang HM
Anal Chem; 2020 Jan; 92(1):1582-1588. PubMed ID: 31815436
[TBL] [Abstract][Full Text] [Related]
12. A heterodimeric Fc-based bispecific antibody simultaneously targeting VEGFR-2 and Met exhibits potent antitumor activity.
Choi HJ; Kim YJ; Lee S; Kim YS
Mol Cancer Ther; 2013 Dec; 12(12):2748-59. PubMed ID: 24132142
[TBL] [Abstract][Full Text] [Related]
13. Improved assembly of bispecific antibodies from knob and hole half-antibodies.
Williams AJ; Giese G; Persson J
Biotechnol Prog; 2015; 31(5):1315-22. PubMed ID: 26097217
[TBL] [Abstract][Full Text] [Related]
14. Structural basis of a novel heterodimeric Fc for bispecific antibody production.
Wei H; Cai H; Jin Y; Wang P; Zhang Q; Lin Y; Wang W; Cheng J; Zeng N; Xu T; Zhou A
Oncotarget; 2017 Aug; 8(31):51037-51049. PubMed ID: 28881627
[TBL] [Abstract][Full Text] [Related]
15. Structural consequences of aglycosylated IgG Fc variants evolved for FcγRI binding.
Ju MS; Na JH; Yu YG; Kim JY; Jeong C; Jung ST
Mol Immunol; 2015 Oct; 67(2 Pt B):350-6. PubMed ID: 26153451
[TBL] [Abstract][Full Text] [Related]
16. Production of bispecific antibodies in "knobs-into-holes" using a cell-free expression system.
Xu Y; Lee J; Tran C; Heibeck TH; Wang WD; Yang J; Stafford RL; Steiner AR; Sato AK; Hallam TJ; Yin G
MAbs; 2015; 7(1):231-42. PubMed ID: 25427258
[TBL] [Abstract][Full Text] [Related]
17. Bispecific antibody process development: Assembly and purification of knob and hole bispecific antibodies.
Giese G; Williams A; Rodriguez M; Persson J
Biotechnol Prog; 2018 Mar; 34(2):397-404. PubMed ID: 29193902
[TBL] [Abstract][Full Text] [Related]
18. Therapeutic assessment of SEED: a new engineered antibody platform designed to generate mono- and bispecific antibodies.
Muda M; Gross AW; Dawson JP; He C; Kurosawa E; Schweickhardt R; Dugas M; Soloviev M; Bernhardt A; Fischer D; Wesolowski JS; Kelton C; Neuteboom B; Hock B
Protein Eng Des Sel; 2011 May; 24(5):447-54. PubMed ID: 21498564
[TBL] [Abstract][Full Text] [Related]
19. Structural determinants of unique properties of human IgG4-Fc.
Davies AM; Rispens T; Ooijevaar-de Heer P; Gould HJ; Jefferis R; Aalberse RC; Sutton BJ
J Mol Biol; 2014 Feb; 426(3):630-44. PubMed ID: 24211234
[TBL] [Abstract][Full Text] [Related]
20. [Interaction between CH2 and CH3-domains of human immunoglobulin G1 in glycosylated and aglycosylated Fc-fragments].
Tishchenko VM
Biofizika; 1999; 44(5):811-2. PubMed ID: 10624519
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]