These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

162 related articles for article (PubMed ID: 2459027)

  • 1. Effects of site specific amino acid exchanges in hirudin on the thrombin-hirudin interaction.
    Köhler S; Dodt J
    Folia Haematol Int Mag Klin Morphol Blutforsch; 1988; 115(1-2):24-9. PubMed ID: 2459027
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure-activity relationships of recombinant hirudins.
    Stürzebecher J; Walsmann P
    Semin Thromb Hemost; 1991 Apr; 17(2):94-8. PubMed ID: 1771418
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Probing the distance between the two binding sites of hirudin for its interaction with the active site and the fibrin(ogen)-binding site of alpha-thrombin.
    Wagner U; Schmitz T; Otte M; Dodt J
    Biomed Biochim Acta; 1991; 50(4-6):707-10. PubMed ID: 1801747
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Electrostatic steering and ionic tethering in the formation of thrombin-hirudin complexes: the role of the thrombin anion-binding exosite-I.
    Myles T; Le Bonniec BF; Betz A; Stone SR
    Biochemistry; 2001 Apr; 40(16):4972-9. PubMed ID: 11305913
    [TBL] [Abstract][Full Text] [Related]  

  • 5. CX-397, a novel recombinant hirudin analog having a hybrid sequence of hirudin variants-1 and -3.
    Komatsu Y; Misawa S; Sukesada A; Ohba Y; Hayashi H
    Biochem Biophys Res Commun; 1993 Oct; 196(2):773-9. PubMed ID: 8240353
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Hirudin: a family of iso-proteins. Isolation and sequence determination of new hirudins.
    Tripier D
    Folia Haematol Int Mag Klin Morphol Blutforsch; 1988; 115(1-2):30-5. PubMed ID: 2459028
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Interaction of site specific hirudin variants with alpha-thrombin.
    Dodt J; Köhler S; Baici A
    FEBS Lett; 1988 Feb; 229(1):87-90. PubMed ID: 3345842
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structure-function and refolding studies of the thrombin-specific inhibitor hirudin.
    Johnson PH; Sze P; Winant RC; Hudson D; Underhill P; Lazar JB; Olsen C; Almquist R
    Haemostasis; 1991; 21 Suppl 1():41-8. PubMed ID: 1894196
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Molecular dynamics simulations of thrombin inhibitors at the S' subsites of thrombin.
    Yue SY; Konishi Y
    Drug Des Discov; 1994 Jul; 12(1):1-17. PubMed ID: 7578804
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Probing the hirudin-thrombin interaction by incorporation of noncoded amino acids and molecular dynamics simulation.
    De Filippis V; Colombo G; Russo I; Spadari B; Fontana A
    Biochemistry; 2002 Nov; 41(46):13556-69. PubMed ID: 12427016
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The hirudin-binding site of human alpha-thrombin. Identification of lysyl residues which participate in the combining site of hirudin-thrombin complex.
    Chang JY
    J Biol Chem; 1989 May; 264(13):7141-6. PubMed ID: 2496126
    [TBL] [Abstract][Full Text] [Related]  

  • 12. [Recent developments in the biochemistry of hirudins].
    Walsmann P
    Folia Haematol Int Mag Klin Morphol Blutforsch; 1989; 116(6):821-30. PubMed ID: 2483699
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Immobilized hirudin and hirudin-based peptides used for the purification of recombinant human thrombin prepared from recombinant human prothrombin.
    Fischer BE; Mitterer A; Schlokat U; Grillberger L; Reiter M; Mundt W; Dorner F; Eibl J
    Protein Expr Purif; 1996 Sep; 8(2):167-74. PubMed ID: 8812854
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The role of the insertion loop around tryptophan 148 in tthe activity of thrombin.
    DiBella EE; Scheraga HA
    Biochemistry; 1996 Apr; 35(14):4427-33. PubMed ID: 8605192
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Design of P1' and P3' residues of trivalent thrombin inhibitors and their crystal structures.
    Slon-Usakiewicz JJ; Sivaraman J; Li Y; Cygler M; Konishi Y
    Biochemistry; 2000 Mar; 39(9):2384-91. PubMed ID: 10694407
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis and characterization of more potent analogues of hirudin fragment 1-47 containing non-natural amino acids.
    De Filippis V; Quarzago D; Vindigni A; Di Cera E; Fontana A
    Biochemistry; 1998 Sep; 37(39):13507-15. PubMed ID: 9753436
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Interaction of hirudin with thrombin: identification of a minimal binding domain of hirudin that inhibits clotting activity.
    Mao SJ; Yates MT; Owen TJ; Krstenansky JL
    Biochemistry; 1988 Oct; 27(21):8170-3. PubMed ID: 3233202
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Interaction of hirudin with the dysthrombins Quick I and II.
    Stone SR; Schmitz T; Henriksen RA; Hofsteenge J; Dodt J
    Biochemistry; 1991 Jul; 30(26):6392-7. PubMed ID: 2054344
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Rational design of true hirudin mimetics: synthesis and characterization of multisite-directed alpha-thrombin inhibitors.
    Lombardi A; Nastri F; Della Morte R; Rossi A; De Rosa A; Staiano N; Pedone C; Pavone V
    J Med Chem; 1996 May; 39(10):2008-17. PubMed ID: 8642559
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Mechanism of the inhibition of alpha-thrombin by hirudin-derived fragments hirudin(1-47) and hirudin(45-65).
    Schmitz T; Rothe M; Dodt J
    Eur J Biochem; 1991 Jan; 195(1):251-6. PubMed ID: 1991472
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.