These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

133 related articles for article (PubMed ID: 24593263)

  • 21. Best practices for metabolite quantification in drug development: updated recommendation from the European Bioanalysis Forum.
    Timmerman P; Blech S; White S; Green M; Delatour C; McDougall S; Mannens G; Smeraglia J; Williams S; Young G
    Bioanalysis; 2016 Jun; 8(12):1297-305. PubMed ID: 27217058
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Drug metabolites in safety testing.
    Hastings KL; El-Hage J; Jacobs A; Leighton J; Morse D; Osterberg RE
    Toxicol Appl Pharmacol; 2003 Jul; 190(1):91-2;author reply 93-4. PubMed ID: 12831788
    [No Abstract]   [Full Text] [Related]  

  • 23. Assessment of exposure of metabolites in preclinical species and humans at steady state from the single-dose radiolabeled absorption, distribution, metabolism, and excretion studies: a case study.
    Prakash C; Li Z; Orlandi C; Klunk L
    Drug Metab Dispos; 2012 Jul; 40(7):1308-20. PubMed ID: 22474055
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Integrated strategies for assessment of metabolite exposure in humans during drug development: analytical challenges and clinical development considerations.
    Zhu M; Zhang D; Zhang H; Shyu WC
    Biopharm Drug Dispos; 2009 May; 30(4):163-84. PubMed ID: 19544287
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Genotoxicity of 1,3-butadiene and its epoxy intermediates.
    Walker VE; Walker DM; Meng Q; McDonald JD; Scott BR; Seilkop SK; Claffey DJ; Upton PB; Powley MW; Swenberg JA; Henderson RF;
    Res Rep Health Eff Inst; 2009 Aug; (144):3-79. PubMed ID: 20017413
    [TBL] [Abstract][Full Text] [Related]  

  • 26. [Pediatric drug development: ICH harmonized tripartite guideline E11 within the United States of America, the European Union, and Japan].
    Pflieger M; Bertram D
    Arch Pediatr; 2014 Oct; 21(10):1129-38. PubMed ID: 25175054
    [TBL] [Abstract][Full Text] [Related]  

  • 27. A Decade in the MIST: Learnings from Investigations of Drug Metabolites in Drug Development under the "Metabolites in Safety Testing" Regulatory Guidance.
    Schadt S; Bister B; Chowdhury SK; Funk C; Hop CECA; Humphreys WG; Igarashi F; James AD; Kagan M; Khojasteh SC; Nedderman ANR; Prakash C; Runge F; Scheible H; Spracklin DK; Swart P; Tse S; Yuan J; Obach RS
    Drug Metab Dispos; 2018 Jun; 46(6):865-878. PubMed ID: 29487142
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Metabolite Identification in the Preclinical and Clinical Phase of Drug Development.
    Wu Y; Pan L; Chen Z; Zheng Y; Diao X; Zhong D
    Curr Drug Metab; 2021; 22(11):838-857. PubMed ID: 34620061
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Anticancer Drug Development: The Way Forward.
    Connors T
    Oncologist; 1996; 1(3):180-181. PubMed ID: 10387985
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Strategy for genotoxicity testing--metabolic considerations.
    Ku WW; Bigger A; Brambilla G; Glatt H; Gocke E; Guzzie PJ; Hakura A; Honma M; Martus HJ; Obach RS; Roberts S;
    Mutat Res; 2007 Feb; 627(1):59-77. PubMed ID: 17141553
    [TBL] [Abstract][Full Text] [Related]  

  • 31. The FDA Maze.
    Levy J
    Cutis; 1982 Jan; 29(1):54-60. PubMed ID: 7035076
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Nonclinical safety biomarkers of drug-induced vascular injury: current status and blueprint for the future.
    Mikaelian I; Cameron M; Dalmas DA; Enerson BE; Gonzalez RJ; Guionaud S; Hoffmann PK; King NM; Lawton MP; Scicchitano MS; Smith HW; Thomas RA; Weaver JL; Zabka TS;
    Toxicol Pathol; 2014 Jun; 42(4):635-57. PubMed ID: 24777748
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Comparative evaluation of US Food and Drug Administration and pharmacologically guided approaches to determine the maximum recommended starting dose for first-in-human clinical trials in adult healthy men.
    Imam MT; Venkateshan SP; Tandon M; Saha N; Pillai KK
    J Clin Pharmacol; 2011 Dec; 51(12):1655-64. PubMed ID: 21415286
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Addressing MIST (Metabolites in Safety Testing): bioanalytical approaches to address metabolite exposures in humans and animals.
    Gao H; Obach RS
    Curr Drug Metab; 2011 Jul; 12(6):578-86. PubMed ID: 21434861
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Interpretation and considerations on the safety evaluation of human drug metabolites.
    Atrakchi AH
    Chem Res Toxicol; 2009 Jul; 22(7):1217-20. PubMed ID: 19563206
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Lessons learned from independent central review.
    Ford R; Schwartz L; Dancey J; Dodd LE; Eisenhauer EA; Gwyther S; Rubinstein L; Sargent D; Shankar L; Therasse P; Verweij J
    Eur J Cancer; 2009 Jan; 45(2):268-74. PubMed ID: 19101138
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Radiolabeled absorption, distribution, metabolism, and excretion studies in drug development: why, when, and how?
    Penner N; Xu L; Prakash C
    Chem Res Toxicol; 2012 Mar; 25(3):513-31. PubMed ID: 22309195
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Metabolite quantitation: detector technology and MIST implications.
    Wright P; Miao Z; Shilliday B
    Bioanalysis; 2009 Jul; 1(4):831-45. PubMed ID: 21083141
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Drug metabolites as cytochrome p450 inhibitors: a retrospective analysis and proposed algorithm for evaluation of the pharmacokinetic interaction potential of metabolites in drug discovery and development.
    Callegari E; Kalgutkar AS; Leung L; Obach RS; Plowchalk DR; Tse S
    Drug Metab Dispos; 2013 Dec; 41(12):2047-55. PubMed ID: 23792812
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Are multimetabolite methods fit-for-purpose for supporting toxicology studies?
    Smith G
    Bioanalysis; 2011 Dec; 3(24):2701-4. PubMed ID: 22185267
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 7.