BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

310 related articles for article (PubMed ID: 24594842)

  • 1. The histone deacetylase HDAC3 is essential for Purkinje cell function, potentially complicating the use of HDAC inhibitors in SCA1.
    Venkatraman A; Hu YS; Didonna A; Cvetanovic M; Krbanjevic A; Bilesimo P; Opal P
    Hum Mol Genet; 2014 Jul; 23(14):3733-45. PubMed ID: 24594842
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Partial loss of Tip60 slows mid-stage neurodegeneration in a spinocerebellar ataxia type 1 (SCA1) mouse model.
    Gehrking KM; Andresen JM; Duvick L; Lough J; Zoghbi HY; Orr HT
    Hum Mol Genet; 2011 Jun; 20(11):2204-12. PubMed ID: 21427130
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Lithium therapy improves neurological function and hippocampal dendritic arborization in a spinocerebellar ataxia type 1 mouse model.
    Watase K; Gatchel JR; Sun Y; Emamian E; Atkinson R; Richman R; Mizusawa H; Orr HT; Shaw C; Zoghbi HY
    PLoS Med; 2007 May; 4(5):e182. PubMed ID: 17535104
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Non-invasive detection of neurochemical changes prior to overt pathology in a mouse model of spinocerebellar ataxia type 1.
    Emir UE; Brent Clark H; Vollmers ML; Eberly LE; Öz G
    J Neurochem; 2013 Dec; 127(5):660-8. PubMed ID: 24032423
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Focused cerebellar laser light induced hyperthermia improves symptoms and pathology of polyglutamine disease SCA1 in a mouse model.
    Hearst SM; Shao Q; Lopez M; Raucher D; Vig PJ
    Cerebellum; 2014 Oct; 13(5):596-606. PubMed ID: 24930030
    [TBL] [Abstract][Full Text] [Related]  

  • 6. miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis.
    Lee Y; Samaco RC; Gatchel JR; Thaller C; Orr HT; Zoghbi HY
    Nat Neurosci; 2008 Oct; 11(10):1137-9. PubMed ID: 18758459
    [TBL] [Abstract][Full Text] [Related]  

  • 7. SCA1-phosphorylation, a regulator of Ataxin-1 function and pathogenesis.
    Orr HT
    Prog Neurobiol; 2012 Dec; 99(3):179-85. PubMed ID: 22531670
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Purkinje cell ataxin-1 modulates climbing fiber synaptic input in developing and adult mouse cerebellum.
    Ebner BA; Ingram MA; Barnes JA; Duvick LA; Frisch JL; Clark HB; Zoghbi HY; Ebner TJ; Orr HT
    J Neurosci; 2013 Mar; 33(13):5806-20. PubMed ID: 23536093
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Partial loss of ataxin-1 function contributes to transcriptional dysregulation in spinocerebellar ataxia type 1 pathogenesis.
    Crespo-Barreto J; Fryer JD; Shaw CA; Orr HT; Zoghbi HY
    PLoS Genet; 2010 Jul; 6(7):e1001021. PubMed ID: 20628574
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Glial S100B protein modulates mutant ataxin-1 aggregation and toxicity: TRTK12 peptide, a potential candidate for SCA1 therapy.
    Vig PJ; Hearst S; Shao Q; Lopez ME; Murphy HA; Safaya E
    Cerebellum; 2011 Jun; 10(2):254-66. PubMed ID: 21384195
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Progress in pathogenesis studies of spinocerebellar ataxia type 1.
    Cummings CJ; Orr HT; Zoghbi HY
    Philos Trans R Soc Lond B Biol Sci; 1999 Jun; 354(1386):1079-81. PubMed ID: 10434309
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Regional rescue of spinocerebellar ataxia type 1 phenotypes by 14-3-3epsilon haploinsufficiency in mice underscores complex pathogenicity in neurodegeneration.
    Jafar-Nejad P; Ward CS; Richman R; Orr HT; Zoghbi HY
    Proc Natl Acad Sci U S A; 2011 Feb; 108(5):2142-7. PubMed ID: 21245341
    [TBL] [Abstract][Full Text] [Related]  

  • 13. SCA1-like disease in mice expressing wild-type ataxin-1 with a serine to aspartic acid replacement at residue 776.
    Duvick L; Barnes J; Ebner B; Agrawal S; Andresen M; Lim J; Giesler GJ; Zoghbi HY; Orr HT
    Neuron; 2010 Sep; 67(6):929-35. PubMed ID: 20869591
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Neuronal Atrophy Early in Degenerative Ataxia Is a Compensatory Mechanism to Regulate Membrane Excitability.
    Dell'Orco JM; Wasserman AH; Chopra R; Ingram MA; Hu YS; Singh V; Wulff H; Opal P; Orr HT; Shakkottai VG
    J Neurosci; 2015 Aug; 35(32):11292-307. PubMed ID: 26269637
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Beyond the glutamine expansion: influence of posttranslational modifications of ataxin-1 in the pathogenesis of spinocerebellar ataxia type 1.
    Ju H; Kokubu H; Lim J
    Mol Neurobiol; 2014 Dec; 50(3):866-874. PubMed ID: 24752589
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Vascular endothelial growth factor ameliorates the ataxic phenotype in a mouse model of spinocerebellar ataxia type 1.
    Cvetanovic M; Patel JM; Marti HH; Kini AR; Opal P
    Nat Med; 2011 Oct; 17(11):1445-7. PubMed ID: 22001907
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Duplication of Atxn1l suppresses SCA1 neuropathology by decreasing incorporation of polyglutamine-expanded ataxin-1 into native complexes.
    Bowman AB; Lam YC; Jafar-Nejad P; Chen HK; Richman R; Samaco RC; Fryer JD; Kahle JJ; Orr HT; Zoghbi HY
    Nat Genet; 2007 Mar; 39(3):373-9. PubMed ID: 17322884
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Recovery from polyglutamine-induced neurodegeneration in conditional SCA1 transgenic mice.
    Zu T; Duvick LA; Kaytor MD; Berlinger MS; Zoghbi HY; Clark HB; Orr HT
    J Neurosci; 2004 Oct; 24(40):8853-61. PubMed ID: 15470152
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegeneration.
    Watase K; Weeber EJ; Xu B; Antalffy B; Yuva-Paylor L; Hashimoto K; Kano M; Atkinson R; Sun Y; Armstrong DL; Sweatt JD; Orr HT; Paylor R; Zoghbi HY
    Neuron; 2002 Jun; 34(6):905-19. PubMed ID: 12086639
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Altered Purkinje cell miRNA expression and SCA1 pathogenesis.
    Rodriguez-Lebron E; Liu G; Keiser M; Behlke MA; Davidson BL
    Neurobiol Dis; 2013 Jun; 54():456-63. PubMed ID: 23376683
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.