164 related articles for article (PubMed ID: 24598749)
1. Structural and thermodynamic basis of the inhibition of Leishmania major farnesyl diphosphate synthase by nitrogen-containing bisphosphonates.
Aripirala S; Gonzalez-Pacanowska D; Oldfield E; Kaiser M; Amzel LM; Gabelli SB
Acta Crystallogr D Biol Crystallogr; 2014 Mar; 70(Pt 3):802-10. PubMed ID: 24598749
[TBL] [Abstract][Full Text] [Related]
2. Identifying Structural Determinants of Product Specificity in
Maheshwari S; Kim YS; Aripirala S; Murphy M; Amzel LM; Gabelli SB
Biochemistry; 2020 Jul; 59(29):2751-2759. PubMed ID: 32584028
[TBL] [Abstract][Full Text] [Related]
3. Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer.
Huang CH; Gabelli SB; Oldfield E; Amzel LM
Proteins; 2010 Mar; 78(4):888-99. PubMed ID: 19876942
[TBL] [Abstract][Full Text] [Related]
4. Structural characterization of a lepidopteran type-II farnesyl diphosphate synthase from the spruce budworm, Choristoneura fumiferana: Implications for inhibitor design.
Picard MÈ; Nisole A; Béliveau C; Sen S; Barbar A; Shi R; Cusson M
Insect Biochem Mol Biol; 2018 Jan; 92():84-92. PubMed ID: 29183817
[TBL] [Abstract][Full Text] [Related]
5. The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.
Kavanagh KL; Guo K; Dunford JE; Wu X; Knapp S; Ebetino FH; Rogers MJ; Russell RG; Oppermann U
Proc Natl Acad Sci U S A; 2006 May; 103(20):7829-34. PubMed ID: 16684881
[TBL] [Abstract][Full Text] [Related]
6. Insights about the structure of farnesyl diphosphate synthase (FPPS) and the activity of bisphosphonates on the proliferation and ultrastructure of Leishmania and Giardia.
Gadelha APR; Brigagao CM; da Silva MB; Rodrigues ABM; Guimarães ACR; Paiva F; de Souza W; Henriques C
Parasit Vectors; 2020 Apr; 13(1):168. PubMed ID: 32248823
[TBL] [Abstract][Full Text] [Related]
7. Disruption of insect isoprenoid biosynthesis with pyridinium bisphosphonates.
Sen SE; Wood L; Jacob R; Xhambazi A; Pease B; Jones A; Horsfield T; Lin A; Cusson M
Insect Biochem Mol Biol; 2015 Aug; 63():113-23. PubMed ID: 26073627
[TBL] [Abstract][Full Text] [Related]
8. Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme's active site closure.
Park J; Lin YS; De Schutter JW; Tsantrizos YS; Berghuis AM
BMC Struct Biol; 2012 Dec; 12():32. PubMed ID: 23234314
[TBL] [Abstract][Full Text] [Related]
9. The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants.
Tsoumpra MK; Muniz JR; Barnett BL; Kwaasi AA; Pilka ES; Kavanagh KL; Evdokimov A; Walter RL; Von Delft F; Ebetino FH; Oppermann U; Russell RGG; Dunford JE
Bone; 2015 Dec; 81():478-486. PubMed ID: 26318908
[TBL] [Abstract][Full Text] [Related]
10. Farnesyl pyrophosphate synthase is essential for the promastigote and amastigote stages in Leishmania major.
Mukherjee S; Basu S; Zhang K
Mol Biochem Parasitol; 2019 Jun; 230():8-15. PubMed ID: 30926449
[TBL] [Abstract][Full Text] [Related]
11. Structural characterization of substrate and inhibitor binding to farnesyl pyrophosphate synthase from Pseudomonas aeruginosa.
Schmidberger JW; Schnell R; Schneider G
Acta Crystallogr D Biol Crystallogr; 2015 Mar; 71(Pt 3):721-31. PubMed ID: 25760619
[TBL] [Abstract][Full Text] [Related]
12. Structures of a potent phenylalkyl bisphosphonate inhibitor bound to farnesyl and geranylgeranyl diphosphate synthases.
Cao R; Chen CK; Guo RT; Wang AH; Oldfield E
Proteins; 2008 Nov; 73(2):431-9. PubMed ID: 18442135
[TBL] [Abstract][Full Text] [Related]
13. Approaches for Designing new Potent Inhibitors of Farnesyl Pyrophosphate Synthase.
Rodriguez JB; Falcone BN; Szajnman SH
Expert Opin Drug Discov; 2016; 11(3):307-20. PubMed ID: 26781029
[TBL] [Abstract][Full Text] [Related]
14. Taxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate site.
Liu YL; Lindert S; Zhu W; Wang K; McCammon JA; Oldfield E
Proc Natl Acad Sci U S A; 2014 Jun; 111(25):E2530-9. PubMed ID: 24927548
[TBL] [Abstract][Full Text] [Related]
15. The farnesyl-diphosphate/geranylgeranyl-diphosphate synthase of Toxoplasma gondii is a bifunctional enzyme and a molecular target of bisphosphonates.
Ling Y; Li ZH; Miranda K; Oldfield E; Moreno SN
J Biol Chem; 2007 Oct; 282(42):30804-16. PubMed ID: 17724033
[TBL] [Abstract][Full Text] [Related]
16. Increasing the intracellular isoprenoid pool in Saccharomyces cerevisiae by structural fine-tuning of a bifunctional farnesyl diphosphate synthase.
Rubat S; Varas I; Sepúlveda R; Almonacid D; González-Nilo F; Agosin E
FEMS Yeast Res; 2017 Jun; 17(4):. PubMed ID: 28854674
[TBL] [Abstract][Full Text] [Related]
17. Enthalpy versus entropy-driven binding of bisphosphonates to farnesyl diphosphate synthase.
Yin F; Cao R; Goddard A; Zhang Y; Oldfield E
J Am Chem Soc; 2006 Mar; 128(11):3524-5. PubMed ID: 16536518
[TBL] [Abstract][Full Text] [Related]
18. Solid-state NMR, crystallographic, and computational investigation of bisphosphonates and farnesyl diphosphate synthase-bisphosphonate complexes.
Mao J; Mukherjee S; Zhang Y; Cao R; Sanders JM; Song Y; Zhang Y; Meints GA; Gao YG; Mukkamala D; Hudock MP; Oldfield E
J Am Chem Soc; 2006 Nov; 128(45):14485-97. PubMed ID: 17090032
[TBL] [Abstract][Full Text] [Related]
19. Pyridinium-1-yl bisphosphonates are potent inhibitors of farnesyl diphosphate synthase and bone resorption.
Sanders JM; Song Y; Chan JM; Zhang Y; Jennings S; Kosztowski T; Odeh S; Flessner R; Schwerdtfeger C; Kotsikorou E; Meints GA; Gómez AO; González-Pacanowska D; Raker AM; Wang H; van Beek ER; Papapoulos SE; Morita CT; Oldfield E
J Med Chem; 2005 Apr; 48(8):2957-63. PubMed ID: 15828834
[TBL] [Abstract][Full Text] [Related]
20. Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: implications for drug design.
Gabelli SB; McLellan JS; Montalvetti A; Oldfield E; Docampo R; Amzel LM
Proteins; 2006 Jan; 62(1):80-8. PubMed ID: 16288456
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]