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6. Clinical Trial of the Protein Farnesylation Inhibitors Lonafarnib, Pravastatin, and Zoledronic Acid in Children With Hutchinson-Gilford Progeria Syndrome. Gordon LB; Kleinman ME; Massaro J; D'Agostino RB; Shappell H; Gerhard-Herman M; Smoot LB; Gordon CM; Cleveland RH; Nazarian A; Snyder BD; Ullrich NJ; Silvera VM; Liang MG; Quinn N; Miller DT; Huh SY; Dowton AA; Littlefield K; Greer MM; Kieran MW Circulation; 2016 Jul; 134(2):114-25. PubMed ID: 27400896 [TBL] [Abstract][Full Text] [Related]
7. Presence and distribution of progerin in HGPS cells is ameliorated by drugs that impact on the mevalonate and mTOR pathways. Clements CS; Bikkul MU; Ofosu W; Eskiw C; Tree D; Makarov E; Kill IR; Bridger JM Biogerontology; 2019 Jun; 20(3):337-358. PubMed ID: 31041622 [TBL] [Abstract][Full Text] [Related]
8. Blocking farnesylation of the prelamin A variant in Hutchinson-Gilford progeria syndrome alters the distribution of A-type lamins. Wang Y; Ostlund C; Choi JC; Swayne TC; Gundersen GG; Worman HJ Nucleus; 2012; 3(5):452-62. PubMed ID: 22895092 [TBL] [Abstract][Full Text] [Related]
9. Farnesyltransferase inhibitor and rapamycin correct aberrant genome organisation and decrease DNA damage respectively, in Hutchinson-Gilford progeria syndrome fibroblasts. Bikkul MU; Clements CS; Godwin LS; Goldberg MW; Kill IR; Bridger JM Biogerontology; 2018 Dec; 19(6):579-602. PubMed ID: 29907918 [TBL] [Abstract][Full Text] [Related]
10. Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin. Yang SH; Chang SY; Ren S; Wang Y; Andres DA; Spielmann HP; Fong LG; Young SG Hum Mol Genet; 2011 Feb; 20(3):436-44. PubMed ID: 21088111 [TBL] [Abstract][Full Text] [Related]
11. N6-isopentenyladenosine improves nuclear shape in fibroblasts from humans with progeroid syndromes by inhibiting the farnesylation of prelamin A. Bifulco M; D'Alessandro A; Paladino S; Malfitano AM; Notarnicola M; Caruso MG; Laezza C FEBS J; 2013 Dec; 280(23):6223-32. PubMed ID: 24112551 [TBL] [Abstract][Full Text] [Related]
12. Plasma Progerin in Patients With Hutchinson-Gilford Progeria Syndrome: Immunoassay Development and Clinical Evaluation. Gordon LB; Norris W; Hamren S; Goodson R; LeClair J; Massaro J; Lyass A; D'Agostino RB; Tuminelli K; Kieran MW; Kleinman ME Circulation; 2023 Jun; 147(23):1734-1744. PubMed ID: 36919608 [TBL] [Abstract][Full Text] [Related]
13. Prelamin A farnesylation and progeroid syndromes. Young SG; Meta M; Yang SH; Fong LG J Biol Chem; 2006 Dec; 281(52):39741-5. PubMed ID: 17090536 [TBL] [Abstract][Full Text] [Related]
14. Hutchinson-Gilford progeria syndrome as a model for vascular aging. Brassard JA; Fekete N; Garnier A; Hoesli CA Biogerontology; 2016 Feb; 17(1):129-45. PubMed ID: 26330290 [TBL] [Abstract][Full Text] [Related]
16. Diminished Canonical β-Catenin Signaling During Osteoblast Differentiation Contributes to Osteopenia in Progeria. Choi JY; Lai JK; Xiong ZM; Ren M; Moorer MC; Stains JP; Cao K J Bone Miner Res; 2018 Nov; 33(11):2059-2070. PubMed ID: 30001457 [TBL] [Abstract][Full Text] [Related]
17. All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype. Pellegrini C; Columbaro M; Capanni C; D'Apice MR; Cavallo C; Murdocca M; Lattanzi G; Squarzoni S Oncotarget; 2015 Oct; 6(30):29914-28. PubMed ID: 26359359 [TBL] [Abstract][Full Text] [Related]
18. Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation. Yang SH; Bergo MO; Toth JI; Qiao X; Hu Y; Sandoval S; Meta M; Bendale P; Gelb MH; Young SG; Fong LG Proc Natl Acad Sci U S A; 2005 Jul; 102(29):10291-6. PubMed ID: 16014412 [TBL] [Abstract][Full Text] [Related]
19. An encouraging progress report on the treatment of progeria and its implications for atherogenesis. Oshima J; Hisama FM; Martin GM Circulation; 2014 Jul; 130(1):4-6. PubMed ID: 24795391 [No Abstract] [Full Text] [Related]
20. Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome. Capell BC; Erdos MR; Madigan JP; Fiordalisi JJ; Varga R; Conneely KN; Gordon LB; Der CJ; Cox AD; Collins FS Proc Natl Acad Sci U S A; 2005 Sep; 102(36):12879-84. PubMed ID: 16129833 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]