414 related articles for article (PubMed ID: 24608250)
1. Impact of the Smoothened inhibitor, IPI-926, on smoothened ciliary localization and Hedgehog pathway activity.
Peluso MO; Campbell VT; Harari JA; Tibbitts TT; Proctor JL; Whitebread N; Conley JM; White KF; Kutok JL; Read MA; McGovern K; Faia KL
PLoS One; 2014; 9(3):e90534. PubMed ID: 24608250
[TBL] [Abstract][Full Text] [Related]
2. Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation.
Wang Y; Zhou Z; Walsh CT; McMahon AP
Proc Natl Acad Sci U S A; 2009 Feb; 106(8):2623-8. PubMed ID: 19196978
[TBL] [Abstract][Full Text] [Related]
3. Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation.
Wang Y; Arvanites AC; Davidow L; Blanchard J; Lam K; Yoo JW; Coy S; Rubin LL; McMahon AP
ACS Chem Biol; 2012 Jun; 7(6):1040-8. PubMed ID: 22554036
[TBL] [Abstract][Full Text] [Related]
4. Vertebrate Smoothened functions at the primary cilium.
Corbit KC; Aanstad P; Singla V; Norman AR; Stainier DY; Reiter JF
Nature; 2005 Oct; 437(7061):1018-21. PubMed ID: 16136078
[TBL] [Abstract][Full Text] [Related]
5. Hedgehog pathway inhibition in chondrosarcoma using the smoothened inhibitor IPI-926 directly inhibits sarcoma cell growth.
Campbell VT; Nadesan P; Ali SA; Wang CY; Whetstone H; Poon R; Wei Q; Keilty J; Proctor J; Wang LW; Apte SS; McGovern K; Alman BA; Wunder JS
Mol Cancer Ther; 2014 May; 13(5):1259-69. PubMed ID: 24634412
[TBL] [Abstract][Full Text] [Related]
6. Response to inhibition of smoothened in diverse epithelial cancer cells that lack smoothened or patched 1 mutations.
Galimberti F; Busch AM; Chinyengetere F; Ma T; Sekula D; Memoli VA; Dragnev KH; Liu F; Johnson KC; Guo Y; Freemantle SJ; Andrew AS; Greninger P; Robbins DJ; Settleman J; Benes C; Dmitrovsky E
Int J Oncol; 2012 Nov; 41(5):1751-61. PubMed ID: 22923130
[TBL] [Abstract][Full Text] [Related]
7. Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium.
Wilson CW; Chen MH; Chuang PT
PLoS One; 2009; 4(4):e5182. PubMed ID: 19365551
[TBL] [Abstract][Full Text] [Related]
8. The intrahepatic signalling niche of hedgehog is defined by primary cilia positive cells during chronic liver injury.
Grzelak CA; Martelotto LG; Sigglekow ND; Patkunanathan B; Ajami K; Calabro SR; Dwyer BJ; Tirnitz-Parker JE; Watkins DN; Warner FJ; Shackel NA; McCaughan GW
J Hepatol; 2014 Jan; 60(1):143-51. PubMed ID: 23978713
[TBL] [Abstract][Full Text] [Related]
9. Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened.
Chen Y; Sasai N; Ma G; Yue T; Jia J; Briscoe J; Jiang J
PLoS Biol; 2011 Jun; 9(6):e1001083. PubMed ID: 21695114
[TBL] [Abstract][Full Text] [Related]
10. Small-molecule modulators of the Sonic Hedgehog signaling pathway.
Stanton BZ; Peng LF
Mol Biosyst; 2010 Jan; 6(1):44-54. PubMed ID: 20024066
[TBL] [Abstract][Full Text] [Related]
11. Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis.
Wu VM; Chen SC; Arkin MR; Reiter JF
Proc Natl Acad Sci U S A; 2012 Aug; 109(34):13644-9. PubMed ID: 22864913
[TBL] [Abstract][Full Text] [Related]
12. Identification and mechanism of action of the acylguanidine MRT-83, a novel potent Smoothened antagonist.
Roudaut H; Traiffort E; Gorojankina T; Vincent L; Faure H; Schoenfelder A; Mann A; Manetti F; Solinas A; Taddei M; Ruat M
Mol Pharmacol; 2011 Mar; 79(3):453-60. PubMed ID: 21177415
[TBL] [Abstract][Full Text] [Related]
13. Self-renewal of acute lymphocytic leukemia cells is limited by the Hedgehog pathway inhibitors cyclopamine and IPI-926.
Lin TL; Wang QH; Brown P; Peacock C; Merchant AA; Brennan S; Jones E; McGovern K; Watkins DN; Sakamoto KM; Matsui W
PLoS One; 2010 Dec; 5(12):e15262. PubMed ID: 21203400
[TBL] [Abstract][Full Text] [Related]
14. Sonic Hedgehog Activates Phospholipase A2 to Enhance Smoothened Ciliary Translocation.
Arensdorf AM; Dillard ME; Menke JM; Frank MW; Rock CO; Ogden SK
Cell Rep; 2017 Jun; 19(10):2074-2087. PubMed ID: 28591579
[TBL] [Abstract][Full Text] [Related]
15. Smoothened as a new therapeutic target for human osteosarcoma.
Hirotsu M; Setoguchi T; Sasaki H; Matsunoshita Y; Gao H; Nagao H; Kunigou O; Komiya S
Mol Cancer; 2010 Jan; 9():5. PubMed ID: 20067614
[TBL] [Abstract][Full Text] [Related]
16. Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5.
Chong YC; Mann RK; Zhao C; Kato M; Beachy PA
Genes Dev; 2015 Feb; 29(3):262-76. PubMed ID: 25644602
[TBL] [Abstract][Full Text] [Related]
17. Tumor shrinkage by cyclopamine tartrate through inhibiting hedgehog signaling.
Fan Q; Gu D; He M; Liu H; Sheng T; Xie G; Li CX; Zhang X; Wainwright B; Garrossian A; Garrossian M; Gardner D; Xie J
Chin J Cancer; 2011 Jul; 30(7):472-81. PubMed ID: 21718593
[TBL] [Abstract][Full Text] [Related]
18. Expression of hedgehog signalling pathway in anaplastic thyroid cancer.
Hinterseher U; Wunderlich A; Roth S; Ramaswamy A; Bartsch DK; Hauptmann S; Greene BH; Fendrich V; Hoffmann S
Endocrine; 2014 Apr; 45(3):439-47. PubMed ID: 23860623
[TBL] [Abstract][Full Text] [Related]
19. Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus.
Kim J; Kato M; Beachy PA
Proc Natl Acad Sci U S A; 2009 Dec; 106(51):21666-71. PubMed ID: 19996169
[TBL] [Abstract][Full Text] [Related]
20. Hedgehog-stimulated chemotaxis is mediated by smoothened located outside the primary cilium.
Bijlsma MF; Damhofer H; Roelink H
Sci Signal; 2012 Aug; 5(238):ra60. PubMed ID: 22912493
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]