278 related articles for article (PubMed ID: 24623674)
1. Repurposing the chemical scaffold of the anti-arthritic drug Lobenzarit to target tryptophan biosynthesis in Mycobacterium tuberculosis.
Evans GL; Gamage SA; Bulloch EM; Baker EN; Denny WA; Lott JS
Chembiochem; 2014 Apr; 15(6):852-64. PubMed ID: 24623674
[TBL] [Abstract][Full Text] [Related]
2. The substrate capture mechanism of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase provides a mode for inhibition.
Castell A; Short FL; Evans GL; Cookson TV; Bulloch EM; Joseph DD; Lee CE; Parker EJ; Baker EN; Lott JS
Biochemistry; 2013 Mar; 52(10):1776-87. PubMed ID: 23363292
[TBL] [Abstract][Full Text] [Related]
3. Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis.
Cookson TV; Castell A; Bulloch EM; Evans GL; Short FL; Baker EN; Lott JS; Parker EJ
Biochem J; 2014 Jul; 461(1):87-98. PubMed ID: 24712732
[TBL] [Abstract][Full Text] [Related]
4. Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site.
Cookson TV; Evans GL; Castell A; Baker EN; Lott JS; Parker EJ
Biochemistry; 2015 Oct; 54(39):6082-92. PubMed ID: 26356348
[TBL] [Abstract][Full Text] [Related]
5. The crystal structure of TrpD, a metabolic enzyme essential for lung colonization by Mycobacterium tuberculosis, in complex with its substrate phosphoribosylpyrophosphate.
Lee CE; Goodfellow C; Javid-Majd F; Baker EN; Shaun Lott J
J Mol Biol; 2006 Jan; 355(4):784-97. PubMed ID: 16337227
[TBL] [Abstract][Full Text] [Related]
6. Development of ssDNA aptamers as potent inhibitors of Mycobacterium tuberculosis acetohydroxyacid synthase.
Baig IA; Moon JY; Lee SC; Ryoo SW; Yoon MY
Biochim Biophys Acta; 2015 Oct; 1854(10 Pt A):1338-50. PubMed ID: 25988243
[TBL] [Abstract][Full Text] [Related]
7. Structure, mechanism and inhibition of anthranilate phosphoribosyltransferase.
Scully TW; Jiao W; Mittelstädt G; Parker EJ
Philos Trans R Soc Lond B Biol Sci; 2023 Feb; 378(1871):20220039. PubMed ID: 36633281
[TBL] [Abstract][Full Text] [Related]
8. Structural comparison of Mtb-DHFR and h-DHFR for design, synthesis and evaluation of selective non-pteridine analogues as antitubercular agents.
Sharma K; Tanwar O; Sharma S; Ali S; Alam MM; Zaman MS; Akhter M
Bioorg Chem; 2018 Oct; 80():319-333. PubMed ID: 29986181
[TBL] [Abstract][Full Text] [Related]
9. A novel inhibitor of indole-3-glycerol phosphate synthase with activity against multidrug-resistant Mycobacterium tuberculosis.
Shen H; Wang F; Zhang Y; Huang Q; Xu S; Hu H; Yue J; Wang H
FEBS J; 2009 Jan; 276(1):144-54. PubMed ID: 19032598
[TBL] [Abstract][Full Text] [Related]
10. Exploiting protein symmetry to design light-controllable enzyme inhibitors.
Reisinger B; Kuzmanovic N; Löffler P; Merkl R; König B; Sterner R
Angew Chem Int Ed Engl; 2014 Jan; 53(2):595-8. PubMed ID: 24520030
[TBL] [Abstract][Full Text] [Related]
11. Identification and development of 2-methylimidazo[1,2-a]pyridine-3-carboxamides as Mycobacterium tuberculosis pantothenate synthetase inhibitors.
Samala G; Nallangi R; Devi PB; Saxena S; Yadav R; Sridevi JP; Yogeeswari P; Sriram D
Bioorg Med Chem; 2014 Aug; 22(15):4223-32. PubMed ID: 24953948
[TBL] [Abstract][Full Text] [Related]
12. Resisting resistant Mycobacterium tuberculosis naturally: mechanistic insights into the inhibition of the parasite's sole signal peptidase Leader peptidase B.
Dhiman H; Dhanjal JK; Sharma S; Chacko S; Grover S; Grover A
Biochem Biophys Res Commun; 2013 Apr; 433(4):552-7. PubMed ID: 23510997
[TBL] [Abstract][Full Text] [Related]
13. Corrigendum: Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis.
Evans GL; Gamage SA; Bulloch EM; Baker EN; Denny WA; Lott JS
Chembiochem; 2015 Mar; 16(5):706. PubMed ID: 26177917
[No Abstract] [Full Text] [Related]
14. Design and Development of Mycobacterium tuberculosis Lysine ɛ-Aminotransferase Inhibitors for Latent Tuberculosis Infection.
Parthiban BD; Saxena S; Chandran M; Jonnalagadda PS; Yadav R; Srilakshmi RR; Perumal Y; Dharmarajan S
Chem Biol Drug Des; 2016 Feb; 87(2):265-74. PubMed ID: 26348876
[TBL] [Abstract][Full Text] [Related]
15. Benzothiazole Derivative as a Novel Mycobacterium tuberculosis Shikimate Kinase Inhibitor: Identification and Elucidation of Its Allosteric Mode of Inhibition.
Mehra R; Rajput VS; Gupta M; Chib R; Kumar A; Wazir P; Khan IA; Nargotra A
J Chem Inf Model; 2016 May; 56(5):930-40. PubMed ID: 27149193
[TBL] [Abstract][Full Text] [Related]
16. Discovery of Schaeffer's acid analogues as lead structures of mycobacterium tuberculosis type II dehydroquinase using a rational drug design approach.
Schmidt MF; Korb O; Howard NI; Dias MV; Blundell TL; Abell C
ChemMedChem; 2013 Jan; 8(1):54-8. PubMed ID: 23169689
[TBL] [Abstract][Full Text] [Related]
17. Molecular determinants of inactivation of the resuscitation promoting factor B from Mycobacterium tuberculosis.
Ruggiero A; Marchant J; Squeglia F; Makarov V; De Simone A; Berisio R
J Biomol Struct Dyn; 2013; 31(2):195-205. PubMed ID: 22831279
[TBL] [Abstract][Full Text] [Related]
18. Comparative protein modeling of methionine S-adenosyltransferase (MAT) enzyme from Mycobacterium tuberculosis: a potential target for antituberculosis drug discovery.
Khedkar SA; Malde AK; Coutinho EC
J Mol Graph Model; 2005 Jan; 23(4):355-66. PubMed ID: 15670956
[TBL] [Abstract][Full Text] [Related]
19. Anthranilate phosphoribosyltransferase: Binding determinants for 5'-phospho-alpha-d-ribosyl-1'-pyrophosphate (PRPP) and the implications for inhibitor design.
Evans GL; Furkert DP; Abermil N; Kundu P; de Lange KM; Parker EJ; Brimble MA; Baker EN; Lott JS
Biochim Biophys Acta Proteins Proteom; 2018 Feb; 1866(2):264-274. PubMed ID: 28844746
[TBL] [Abstract][Full Text] [Related]
20. Insights into the bonding pattern for characterizing the open and closed state of the substrate-binding loop in Mycobacterium tuberculosis InhA.
Kumar V; Sobhia ME
Future Med Chem; 2014 Apr; 6(6):605-16. PubMed ID: 24895891
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]