These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

88 related articles for article (PubMed ID: 24631873)

  • 1. Toward activated homology models of the human M1 muscarinic acetylcholine receptor.
    Chin SP; Buckle MJ; Chalmers DK; Yuriev E; Doughty SW
    J Mol Graph Model; 2014 Apr; 49():91-8. PubMed ID: 24631873
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The M1 muscarinic receptor allosteric agonists AC-42 and 1-[1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one bind to a unique site distinct from the acetylcholine orthosteric site.
    Jacobson MA; Kreatsoulas C; Pascarella DM; O'Brien JA; Sur C
    Mol Pharmacol; 2010 Oct; 78(4):648-57. PubMed ID: 20660086
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The predicted 3D structures of the human M1 muscarinic acetylcholine receptor with agonist or antagonist bound.
    Peng JY; Vaidehi N; Hall SE; Goddard WA
    ChemMedChem; 2006 Aug; 1(8):878-90. PubMed ID: 16902941
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Intracellular localization of the M1 muscarinic acetylcholine receptor through clathrin-dependent constitutive internalization is mediated by a C-terminal tryptophan-based motif.
    Uwada J; Yoshiki H; Masuoka T; Nishio M; Muramatsu I
    J Cell Sci; 2014 Jul; 127(Pt 14):3131-40. PubMed ID: 24829147
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Protein-based virtual screening of chemical databases. II. Are homology models of G-Protein Coupled Receptors suitable targets?
    Bissantz C; Bernard P; Hibert M; Rognan D
    Proteins; 2003 Jan; 50(1):5-25. PubMed ID: 12471595
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Identification of multiple allosteric sites on the M1 muscarinic acetylcholine receptor.
    Espinoza-Fonseca LM; Trujillo-Ferrara JG
    FEBS Lett; 2005 Dec; 579(30):6726-32. PubMed ID: 16310776
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Virtual screening of biogenic amine-binding G-protein coupled receptors: comparative evaluation of protein- and ligand-based virtual screening protocols.
    Evers A; Hessler G; Matter H; Klabunde T
    J Med Chem; 2005 Aug; 48(17):5448-65. PubMed ID: 16107144
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Crystal structures of the M1 and M4 muscarinic acetylcholine receptors.
    Thal DM; Sun B; Feng D; Nawaratne V; Leach K; Felder CC; Bures MG; Evans DA; Weis WI; Bachhawat P; Kobilka TS; Sexton PM; Kobilka BK; Christopoulos A
    Nature; 2016 Mar; 531(7594):335-40. PubMed ID: 26958838
    [TBL] [Abstract][Full Text] [Related]  

  • 9. GPCR activation: a mutagenic spotlight on crystal structures.
    Hulme EC
    Trends Pharmacol Sci; 2013 Jan; 34(1):67-84. PubMed ID: 23245528
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and SAR of selective muscarinic acetylcholine receptor subtype 1 (M1 mAChR) antagonists.
    Lewis LM; Sheffler D; Williams R; Bridges TM; Kennedy JP; Brogan JT; Mulder MJ; Williams L; Nalywajko NT; Niswender CM; Weaver CD; Conn PJ; Lindsley CW
    Bioorg Med Chem Lett; 2008 Feb; 18(3):885-90. PubMed ID: 18178088
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Homology modeling of human muscarinic acetylcholine receptors.
    Thomas T; McLean KC; McRobb FM; Manallack DT; Chalmers DK; Yuriev E
    J Chem Inf Model; 2014 Jan; 54(1):243-53. PubMed ID: 24328076
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structure and dynamics of the full-length M1 muscarinic acetylcholine receptor studied by molecular dynamics simulations.
    Espinoza-Fonseca LM; Pedretti A; Vistoli G
    Arch Biochem Biophys; 2008 Jan; 469(1):142-50. PubMed ID: 17935687
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery of subtype selective muscarinic receptor antagonists as alternatives to atropine using in silico pharmacophore modeling and virtual screening methods.
    Bhattacharjee AK; Pomponio JW; Evans SA; Pervitsky D; Gordon RK
    Bioorg Med Chem; 2013 May; 21(9):2651-62. PubMed ID: 23523385
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Pharmacological characterization of LY593093, an M1 muscarinic acetylcholine receptor-selective partial orthosteric agonist.
    Watt ML; Schober DA; Hitchcock S; Liu B; Chesterfield AK; McKinzie D; Felder CC
    J Pharmacol Exp Ther; 2011 Aug; 338(2):622-32. PubMed ID: 21558436
    [TBL] [Abstract][Full Text] [Related]  

  • 15. On the unique binding and activating properties of xanomeline at the M1 muscarinic acetylcholine receptor.
    Christopoulos A; Pierce TL; Sorman JL; El-Fakahany EE
    Mol Pharmacol; 1998 Jun; 53(6):1120-30. PubMed ID: 9614217
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Reverse engineering of the selective agonist TBPB unveils both orthosteric and allosteric modes of action at the M₁ muscarinic acetylcholine receptor.
    Keov P; Valant C; Devine SM; Lane JR; Scammells PJ; Sexton PM; Christopoulos A
    Mol Pharmacol; 2013 Sep; 84(3):425-37. PubMed ID: 23798605
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Antagonist binding in the rat muscarinic receptor A study by docking and X-ray crystallography.
    Tanczos AC; Palmer RA; Potter BS; Saldanha JW; Howlin BJ
    Comput Biol Chem; 2004 Dec; 28(5-6):375-85. PubMed ID: 15556478
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The structure of active opsin as a basis for identification of GPCR agonists by dynamic homology modelling and virtual screening assays.
    Schneider M; Wolf S; Schlitter J; Gerwert K
    FEBS Lett; 2011 Nov; 585(22):3587-92. PubMed ID: 22027616
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Reliability of Docking-Based Virtual Screening for GPCR Ligands with Homology Modeled Structures: A Case Study of the Angiotensin II Type I Receptor.
    Chen H; Fu W; Wang Z; Wang X; Lei T; Zhu F; Li D; Chang S; Xu L; Hou T
    ACS Chem Neurosci; 2019 Jan; 10(1):677-689. PubMed ID: 30265513
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Current assessment of docking into GPCR crystal structures and homology models: successes, challenges, and guidelines.
    Beuming T; Sherman W
    J Chem Inf Model; 2012 Dec; 52(12):3263-77. PubMed ID: 23121495
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.