219 related articles for article (PubMed ID: 24632684)
1. Skp2 suppresses apoptosis in Rb1-deficient tumours by limiting E2F1 activity.
Lu Z; Bauzon F; Fu H; Cui J; Zhao H; Nakayama K; Nakayama KI; Zhu L
Nat Commun; 2014 Mar; 5():3463. PubMed ID: 24632684
[TBL] [Abstract][Full Text] [Related]
2. Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/- mice.
Wang H; Bauzon F; Ji P; Xu X; Sun D; Locker J; Sellers RS; Nakayama K; Nakayama KI; Cobrinik D; Zhu L
Nat Genet; 2010 Jan; 42(1):83-8. PubMed ID: 19966802
[TBL] [Abstract][Full Text] [Related]
3. p27T187A knockin identifies Skp2/Cks1 pocket inhibitors for advanced prostate cancer.
Zhao H; Lu Z; Bauzon F; Fu H; Cui J; Locker J; Zhu L
Oncogene; 2017 Jan; 36(1):60-70. PubMed ID: 27181203
[TBL] [Abstract][Full Text] [Related]
4. Deletions of Retinoblastoma 1 (Rb1) and Its Repressing Target S Phase Kinase-associated protein 2 (Skp2) Are Synthetic Lethal in Mouse Embryogenesis.
Zhao H; Wang H; Bauzon F; Lu Z; Fu H; Cui J; Zhu L
J Biol Chem; 2016 May; 291(19):10201-9. PubMed ID: 26966181
[TBL] [Abstract][Full Text] [Related]
5. Racing to block tumorigenesis after pRb loss: an innocuous point mutation wins with synthetic lethality.
Bauzon F; Zhu L
Cell Cycle; 2010 Jun; 9(11):2118-23. PubMed ID: 20505340
[TBL] [Abstract][Full Text] [Related]
6. Targeted Inhibition of the E3 Ligase SCF
Zhao H; Iqbal NJ; Sukrithan V; Nicholas C; Xue Y; Yu C; Locker J; Zou J; Schwartz EL; Zhu L
Cancer Res; 2020 Jun; 80(11):2355-2367. PubMed ID: 32265224
[TBL] [Abstract][Full Text] [Related]
7. Targeting the untargetable: RB1-deficient tumours are vulnerable to Skp2 ubiquitin ligase inhibition.
Gupta P; Zhao H; Hoang B; Schwartz EL
Br J Cancer; 2022 Oct; 127(6):969-975. PubMed ID: 35752713
[TBL] [Abstract][Full Text] [Related]
8. Substituting threonine 187 with alanine in p27Kip1 prevents pituitary tumorigenesis by two-hit loss of Rb1 and enhances humoral immunity in old age.
Zhao H; Bauzon F; Bi E; Yu JJ; Fu H; Lu Z; Cui J; Jeon H; Zang X; Ye BH; Zhu L
J Biol Chem; 2015 Feb; 290(9):5797-809. PubMed ID: 25583987
[TBL] [Abstract][Full Text] [Related]
9. Targeted pharmacologic inhibition of S-phase kinase-associated protein 2 (SKP2) mediated cell cycle regulation in lung and other RB-Related cancers: A brief review of current status and future prospects.
Elahi AH; Morales CS; Xu XL; Eliades A; Patsalis PC; Abramson DH; Jhanwar SC
Adv Biol Regul; 2023 May; 88():100964. PubMed ID: 37004354
[TBL] [Abstract][Full Text] [Related]
10. Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice.
Yamasaki L; Bronson R; Williams BO; Dyson NJ; Harlow E; Jacks T
Nat Genet; 1998 Apr; 18(4):360-4. PubMed ID: 9537419
[TBL] [Abstract][Full Text] [Related]
11. Epidermal growth factor upregulates Skp2/Cks1 and p27(kip1) in human extrahepatic cholangiocarcinoma cells.
Kim JY; Kim HJ; Park JH; Park DI; Cho YK; Sohn CI; Jeon WK; Kim BI; Kim DH; Chae SW; Sohn JH
World J Gastroenterol; 2014 Jan; 20(3):755-73. PubMed ID: 24574749
[TBL] [Abstract][Full Text] [Related]
12. E2F1 loss induces spontaneous tumour development in Rb-deficient epidermis.
Costa C; Santos M; Martínez-Fernández M; Dueñas M; Lorz C; García-Escudero R; Paramio JM
Oncogene; 2013 Jun; 32(24):2937-51. PubMed ID: 22890321
[TBL] [Abstract][Full Text] [Related]
13. SKP2 Activation by Thyroid Hormone Receptor β2 Bypasses Rb-Dependent Proliferation in Rb-Deficient Cells.
Xu XL; Li Z; Liu A; Fan X; Hu DN; Qi DL; Chitty DW; Jia R; Qui J; Wang JQ; Sharaf J; Zou J; Weiss R; Huang H; Joseph WJ; Ng L; Rosen R; Shen B; Reid MW; Forrest D; Abramson DH; Singer S; Cobrinik D; Jhanwar SC
Cancer Res; 2017 Dec; 77(24):6838-6850. PubMed ID: 28972075
[TBL] [Abstract][Full Text] [Related]
14. The CDKN1B-RB1-E2F1 pathway protects mouse spermatogonial stem cells from genomic damage.
Tanaka T; Kanatsu-Shinohara M; Shinohara T
J Reprod Dev; 2015; 61(4):305-16. PubMed ID: 25959802
[TBL] [Abstract][Full Text] [Related]
15. Flavokawain A induces deNEDDylation and Skp2 degradation leading to inhibition of tumorigenesis and cancer progression in the TRAMP transgenic mouse model.
Li X; Yokoyama NN; Zhang S; Ding L; Liu HM; Lilly MB; Mercola D; Zi X
Oncotarget; 2015 Dec; 6(39):41809-24. PubMed ID: 26497688
[TBL] [Abstract][Full Text] [Related]
16. Retinoblastoma 1 protects T cell maturation from premature apoptosis by inhibiting E2F1.
Zhang Z; Liu W; Zhao L; Huang Z; Chen X; Ma N; Xu J; Zhang W; Zhang Y
Development; 2018 Jan; 145(1):. PubMed ID: 29229770
[TBL] [Abstract][Full Text] [Related]
17. DNA damage signals through differentially modified E2F1 molecules to induce apoptosis.
Carnevale J; Palander O; Seifried LA; Dick FA
Mol Cell Biol; 2012 Mar; 32(5):900-12. PubMed ID: 22184068
[TBL] [Abstract][Full Text] [Related]
18. E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8.
Morris EJ; Ji JY; Yang F; Di Stefano L; Herr A; Moon NS; Kwon EJ; Haigis KM; Näär AM; Dyson NJ
Nature; 2008 Sep; 455(7212):552-6. PubMed ID: 18794899
[TBL] [Abstract][Full Text] [Related]
19. The silencing of long non-coding RNA ANRIL suppresses invasion, and promotes apoptosis of retinoblastoma cells through the ATM-E2F1 signaling pathway.
Yang Y; Peng XW
Biosci Rep; 2018 Dec; 38(6):. PubMed ID: 30355646
[TBL] [Abstract][Full Text] [Related]
20. Transcriptional repression of SKP2 is impaired in MYCN-amplified neuroblastoma.
Muth D; Ghazaryan S; Eckerle I; Beckett E; Pöhler C; Batzler J; Beisel C; Gogolin S; Fischer M; Henrich KO; Ehemann V; Gillespie P; Schwab M; Westermann F
Cancer Res; 2010 May; 70(9):3791-802. PubMed ID: 20424123
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]