BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

176 related articles for article (PubMed ID: 24645879)

  • 1. Resonance Raman spectroscopy of the oxygenated intermediates of human CYP19A1 implicates a compound i intermediate in the final lyase step.
    Mak PJ; Luthra A; Sligar SG; Kincaid JR
    J Am Chem Soc; 2014 Apr; 136(13):4825-8. PubMed ID: 24645879
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Kinetic solvent isotope effect in steady-state turnover by CYP19A1 suggests involvement of Compound 1 for both hydroxylation and aromatization steps.
    Khatri Y; Luthra A; Duggal R; Sligar SG
    FEBS Lett; 2014 Aug; 588(17):3117-22. PubMed ID: 24997347
    [TBL] [Abstract][Full Text] [Related]  

  • 3. QM/MM modeling of the hydroxylation of the androstenedione substrate catalyzed by cytochrome P450 aromatase (CYP19A1).
    Viciano I; Castillo R; Martí S
    J Comput Chem; 2015 Sep; 36(23):1736-47. PubMed ID: 26096372
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Human placental estrogen synthetase (aromatase). Effect of environment on the kinetics of protein-protein and substrate-protein interactions and the production of 19-oxygenated androgen intermediates in the purified reconstituted cytochrome P450 enzyme system.
    Sethumadhavan K; Bellino FL
    J Steroid Biochem Mol Biol; 1991 Sep; 39(3):381-94. PubMed ID: 1911429
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Cytochrome b
    Duggal R; Denisov IG; Sligar SG
    FEBS Lett; 2018 Jul; 592(13):2282-2288. PubMed ID: 29888793
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Raman evidence for specific substrate-induced structural changes in the heme pocket of human cytochrome P450 aromatase during the three consecutive oxygen activation steps.
    Tosha T; Kagawa N; Ohta T; Yoshioka S; Waterman MR; Kitagawa T
    Biochemistry; 2006 May; 45(17):5631-40. PubMed ID: 16634644
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Human Cytochrome CYP17A1: The Structural Basis for Compromised Lyase Activity with 17-Hydroxyprogesterone.
    Mak PJ; Duggal R; Denisov IG; Gregory MC; Sligar SG; Kincaid JR
    J Am Chem Soc; 2018 Jun; 140(23):7324-7331. PubMed ID: 29758981
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Differential effects of variations in human P450 oxidoreductase on the aromatase activity of CYP19A1 polymorphisms R264C and R264H.
    Parween S; DiNardo G; Baj F; Zhang C; Gilardi G; Pandey AV
    J Steroid Biochem Mol Biol; 2020 Feb; 196():105507. PubMed ID: 31669572
    [TBL] [Abstract][Full Text] [Related]  

  • 9. P450 CYP17A1 Variant with a Disordered Proton Shuttle Assembly Retains Peroxo-Mediated Lyase Efficiency.
    Liu Y; Denisov IG; Grinkova YV; Sligar SG; Kincaid JR
    Chemistry; 2020 Dec; 26(70):16846-16852. PubMed ID: 32681807
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Accumulation of intermediates and isotopically sensitive enolization distinguish between aromatase (cytochrome P450 CYP19) from rat ovary and human placenta.
    Swinney DC; Watson DM; So OY
    Arch Biochem Biophys; 1993 Aug; 305(1):61-7. PubMed ID: 8342956
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The steroid metabolite 16(β)-OH-androstenedione generated by CYP21A2 serves as a substrate for CYP19A1.
    Neunzig J; Milhim M; Schiffer L; Khatri Y; Zapp J; Sánchez-Guijo A; Hartmann MF; Wudy SA; Bernhardt R
    J Steroid Biochem Mol Biol; 2017 Mar; 167():182-191. PubMed ID: 28065637
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A Dehydrogenase Dual Hydrogen Abstraction Mechanism Promotes Estrogen Biosynthesis: Can We Expand the Functional Annotation of the Aromatase Enzyme?
    Spinello A; Pavlin M; Casalino L; Magistrato A
    Chemistry; 2018 Jul; 24(42):10840-10849. PubMed ID: 29770981
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Cryoradiolysis of oxygenated cytochrome P450 17A1 with lyase substrates generates expected products.
    Usai R; Denisov IG; Sligar SG; Kincaid JR
    J Inorg Biochem; 2024 Aug; 257():112582. PubMed ID: 38723329
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Biophysical characterization of Aptenodytes forsteri cytochrome P450 aromatase.
    Zarate-Perez F; Velázquez-Fernández JB; Jennings GK; Shock LS; Lyons CE; Hackett JC
    J Inorg Biochem; 2018 Jul; 184():79-87. PubMed ID: 29684698
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Evidence for an elevated aspartate pK(a) in the active site of human aromatase.
    Di Nardo G; Breitner M; Bandino A; Ghosh D; Jennings GK; Hackett JC; Gilardi G
    J Biol Chem; 2015 Jan; 290(2):1186-96. PubMed ID: 25425647
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Alterations in luteal production of androstenedione, testosterone, and estrone, but not estradiol, during mid- and late pregnancy in pigs: effects of androgen deficiency.
    Grzesiak M; Knapczyk-Stwora K; Ciereszko RE; Wieciech I; Slomczynska M
    Theriogenology; 2014 Sep; 82(5):720-33. PubMed ID: 25011982
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Kinetic analysis of the three-step steroid aromatase reaction of human cytochrome P450 19A1.
    Sohl CD; Guengerich FP
    J Biol Chem; 2010 Jun; 285(23):17734-43. PubMed ID: 20385561
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Active site proton delivery and the lyase activity of human CYP17A1.
    Khatri Y; Gregory MC; Grinkova YV; Denisov IG; Sligar SG
    Biochem Biophys Res Commun; 2014 Jan; 443(1):179-84. PubMed ID: 24299954
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Acyl-Carbon Bond Cleaving Cytochrome P450 Enzymes: CYP17A1, CYP19A1 and CYP51A1.
    Akhtar M; Wright JN
    Adv Exp Med Biol; 2015; 851():107-30. PubMed ID: 26002733
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A common polymorphism in the human aromatase gene alters the risk for polycystic ovary syndrome and modifies aromatase activity in vitro.
    Wang H; Li Q; Wang T; Yang G; Wang Y; Zhang X; Sang Q; Wang H; Zhao X; Xing Q; Shi J; He L; Wang L
    Mol Hum Reprod; 2011 Jun; 17(6):386-91. PubMed ID: 21282199
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.