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2. Interaction of polyglutamyl derivatives of methotrexate, 10-deazaaminopterin, and dihydrofolate with dihydrofolate reductase. Kumar P; Kisliuk RL; Gaumont Y; Nair MG; Baugh CM; Kaufman BT Cancer Res; 1986 Oct; 46(10):5020-3. PubMed ID: 2428470 [TBL] [Abstract][Full Text] [Related]
3. Mechanisms of sensitivity and natural resistance to antifolates in a methylcholanthrene-induced rat sarcoma. Li WW; Lin JT; Schweitzer BI; Bertino JR Mol Pharmacol; 1991 Nov; 40(5):854-8. PubMed ID: 1719370 [TBL] [Abstract][Full Text] [Related]
4. Synthesis and biological evaluation of poly-gamma-glutamyl metabolites of 10-deazaaminopterin and 10-ethyl-10-deazaaminopterin. Nair MG; Nanavati NT; Kumar P; Gaumont Y; Kisliuk RL J Med Chem; 1988 Jan; 31(1):181-5. PubMed ID: 2447278 [TBL] [Abstract][Full Text] [Related]
5. Predictions of a network thermodynamics computer model relating to the mechanism of methotrexate rescue by 5-formyltetrahydrofolate and to the importance of inhibition of thymidylate synthase by methotrexate-polyglutamates. White JC Adv Exp Med Biol; 1983; 163():305-26. PubMed ID: 6193692 [TBL] [Abstract][Full Text] [Related]
6. Cytotoxicity, uptake, polyglutamate formation, and antileukemic effects of 8-deaza analogues of methotrexate and aminopterin in mice. Kuehl M; Brixner DI; Broom AD; Avery TL; Blakley RL Cancer Res; 1988 Mar; 48(6):1481-8. PubMed ID: 2449950 [TBL] [Abstract][Full Text] [Related]
7. Inhibition of folate-dependent enzymes by 7-OH-methotrexate. Sholar PW; Baram J; Seither R; Allegra CJ Biochem Pharmacol; 1988 Sep; 37(18):3531-4. PubMed ID: 2458733 [No Abstract] [Full Text] [Related]
8. Effects on dihydrofolate reductase of methotrexate metabolites and intracellular folates formed following methotrexate exposure of human breast cancer cells. Drake JC; Allegra CJ; Baram J; Kaufman BT; Chabner BA Biochem Pharmacol; 1987 Jul; 36(14):2416-8. PubMed ID: 2440441 [No Abstract] [Full Text] [Related]
9. Analog specific aberrancies in antifolate inhibition of L1210 cell dihydrofolate reductase. Sirotnak FM; Chello PL; Moccio DM; Piper JR; Montgomery JA; Parham JC Biochem Pharmacol; 1980 Dec; 29(24):3293-8. PubMed ID: 7213404 [No Abstract] [Full Text] [Related]
10. Inhibitory action of 10-deazaaminopterins and their polyglutamates on human thymidylate synthase. Ueda T; Dutschman GE; Nair MG; Degraw JI; Sirotnak FM; Cheng YC Mol Pharmacol; 1986 Aug; 30(2):149-53. PubMed ID: 2426568 [TBL] [Abstract][Full Text] [Related]
11. Inhibition of dihydrofolate reductase from bacterial and vertebrate sources by folate, aminopterin, methotrexate and their 5-deaza analogues. Stone SR; Montgomery JA; Morrison JF Biochem Pharmacol; 1984 Jan; 33(2):175-9. PubMed ID: 6367748 [TBL] [Abstract][Full Text] [Related]
12. Interaction of methotrexate polyglutamates and dihydrofolate during leucovorin rescue in a human breast cancer cell line (MCF-7). Allegra CJ; Boarman D Cancer Res; 1990 Jun; 50(12):3574-8. PubMed ID: 1692762 [TBL] [Abstract][Full Text] [Related]
13. Synthesis and biological activity of the 2-desamino and 2-desamino-2-methyl analogues of aminopterin and methotrexate. Rosowsky A; Forsch RA; Moran RG; Freisheim JH J Med Chem; 1991 Jan; 34(1):227-34. PubMed ID: 1992122 [TBL] [Abstract][Full Text] [Related]
14. Mechanism-based approaches to inhibition of the synthesis and degradation of folate and antifolate polyglutamates. Kalman TI Adv Exp Med Biol; 1993; 338():639-43. PubMed ID: 7508172 [No Abstract] [Full Text] [Related]
15. Reduced forms of aminopterin and methotrexate in L1210 lymphoma. Makulu DR; Fölsch E J Natl Cancer Inst; 1977 Jul; 59(1):245-9. PubMed ID: 875056 [TBL] [Abstract][Full Text] [Related]
16. Methotrexate analogues-27. Dual inhibition of dihydrofolate reductase and folylpolyglutamate synthetase by methotrexate and aminopterin analogues with a gamma-phosphonate group in the side chain. Rosowsky A; Moran RC; Forsch RA; Radike-Smith M; Colman PD; Wick MM; Freisheim JH Biochem Pharmacol; 1986 Oct; 35(19):3327-33. PubMed ID: 3768024 [TBL] [Abstract][Full Text] [Related]
17. Methotrexate polyglutamate synthesis by cultured human breast cancer cells. Schilsky RL; Bailey BD; Chabner BA Proc Natl Acad Sci U S A; 1980 May; 77(5):2919-22. PubMed ID: 6156458 [TBL] [Abstract][Full Text] [Related]
18. Importance of pharmacodynamics in the in vitro antiproliferative activity of the antifolates methotrexate and 10-ethyl-10-deazaaminopterin against human head and neck squamous cell carcinoma. Braakhuis BJ; Jansen G; Noordhuis P; Kegel A; Peters GJ Biochem Pharmacol; 1993 Dec; 46(12):2155-61. PubMed ID: 7506025 [TBL] [Abstract][Full Text] [Related]
19. Synthesis and retention of methotrexate polyglutamates by human small cell lung cancer. Curt GA; Jolivet J; Bailey BD; Carney DN; Chabner BA Biochem Pharmacol; 1984 May; 33(10):1682-5. PubMed ID: 6203536 [No Abstract] [Full Text] [Related]
20. Polyglutamylation of the dihydrofolate reductase inhibitor gamma-methylene-10-deazaaminopterin is not essential for antitumor activity. Cao S; Abraham A; Nair MG; Pati R; Galivan JH; Hausheer FH; Rustum YM Clin Cancer Res; 1996 Apr; 2(4):707-12. PubMed ID: 9816221 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]