These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

161 related articles for article (PubMed ID: 24650704)

  • 1. Using 'biased-privileged' scaffolds to identify lysine methyltransferase inhibitors.
    Kashyap S; Sandler J; Peters U; Martinez EJ; Kapoor TM
    Bioorg Med Chem; 2014 Apr; 22(7):2253-60. PubMed ID: 24650704
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Insights for the design of protein lysine methyltransferase G9a inhibitors.
    Charles MRC; Dhayalan A; Hsieh HP; Coumar MS
    Future Med Chem; 2019 May; 11(9):993-1014. PubMed ID: 31141392
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a.
    Liu F; Chen X; Allali-Hassani A; Quinn AM; Wasney GA; Dong A; Barsyte D; Kozieradzki I; Senisterra G; Chau I; Siarheyeva A; Kireev DB; Jadhav A; Herold JM; Frye SV; Arrowsmith CH; Brown PJ; Simeonov A; Vedadi M; Jin J
    J Med Chem; 2009 Dec; 52(24):7950-3. PubMed ID: 19891491
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Sinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2.
    Zheng W; Ibáñez G; Wu H; Blum G; Zeng H; Dong A; Li F; Hajian T; Allali-Hassani A; Amaya MF; Siarheyeva A; Yu W; Brown PJ; Schapira M; Vedadi M; Min J; Luo M
    J Am Chem Soc; 2012 Oct; 134(43):18004-14. PubMed ID: 23043551
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Design and synthesis of peptide-MCA substrates for a novel assay of histone methyltransferases and their inhibitors.
    Chi H; Takemoto Y; Nsiama TK; Kato T; Nishino N; Ito A; Yoshida M
    Bioorg Med Chem; 2014 Feb; 22(4):1268-75. PubMed ID: 24486204
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Development of novel bisubstrate-type inhibitors of histone methyltransferase SET7/9.
    Mori S; Iwase K; Iwanami N; Tanaka Y; Kagechika H; Hirano T
    Bioorg Med Chem; 2010 Dec; 18(23):8158-66. PubMed ID: 21036620
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inhibition of histone lysine methyltransferases G9a and GLP by ejection of structural Zn(II).
    Lenstra DC; Al Temimi AHK; Mecinović J
    Bioorg Med Chem Lett; 2018 Apr; 28(7):1234-1238. PubMed ID: 29519735
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Identification and Characterizations of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Scaffold Hopping- and 2D-Molecular Fingerprint-Based Similarity Search.
    Ding H; Lu WC; Hu JC; Liu YC; Zhang CH; Lian FL; Zhang NX; Meng FW; Luo C; Chen KX
    Molecules; 2018 Mar; 23(3):. PubMed ID: 29498708
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase.
    Kubicek S; O'Sullivan RJ; August EM; Hickey ER; Zhang Q; Teodoro ML; Rea S; Mechtler K; Kowalski JA; Homon CA; Kelly TA; Jenuwein T
    Mol Cell; 2007 Feb; 25(3):473-81. PubMed ID: 17289593
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of novel histone lysine methyltransferase G9a/GLP (EHMT2/1) inhibitors: Design, synthesis, and structure-activity relationships of 2,4-diamino-6-methylpyrimidines.
    Katayama K; Ishii K; Tsuda E; Yotsumoto K; Hiramoto K; Suzuki M; Yasumatsu I; Igarashi W; Torihata M; Ishiyama T; Katagiri T
    Bioorg Med Chem Lett; 2020 Oct; 30(20):127475. PubMed ID: 32781218
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Progress in the Development of Lysine Methyltransferase SETD8 Inhibitors.
    Milite C; Feoli A; Viviano M; Rescigno D; Mai A; Castellano S; Sbardella G
    ChemMedChem; 2016 Aug; 11(16):1680-5. PubMed ID: 27411844
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structure-activity relationship studies of G9a-like protein (GLP) inhibitors.
    Xiong Y; Li F; Babault N; Wu H; Dong A; Zeng H; Chen X; Arrowsmith CH; Brown PJ; Liu J; Vedadi M; Jin J
    Bioorg Med Chem; 2017 Aug; 25(16):4414-4423. PubMed ID: 28662962
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A direct label-free MALDI-TOF mass spectrometry based assay for the characterization of inhibitors of protein lysine methyltransferases.
    Guitot K; Drujon T; Burlina F; Sagan S; Beaupierre S; Pamlard O; Dodd RH; Guillou C; Bolbach G; Sachon E; Guianvarc'h D
    Anal Bioanal Chem; 2017 Jun; 409(15):3767-3777. PubMed ID: 28389916
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The discovery of novel histone lysine methyltransferase G9a inhibitors (part 1): molecular design based on a series of substituted 2,4-diamino-7- aminoalkoxyquinazoline by molecular-docking-guided 3D quantitative structure-activity relationship studies.
    Feng T; Wang H; Zhang X; Sun H; You Q
    Med Chem; 2014 Jun; 10(4):426-40. PubMed ID: 24151879
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Lead discovery, chemical optimization, and biological evaluation studies of novel histone methyltransferase SET7 small-molecule inhibitors.
    Hou Z; Min W; Zhang R; Niu A; Li Y; Cao L; Han J; Luo C; Yang P; Ding H
    Bioorg Med Chem Lett; 2020 May; 30(9):127061. PubMed ID: 32173197
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Amide-derived lysine analogues as substrates and inhibitors of histone lysine methyltransferases and acetyltransferases.
    Hintzen JCJ; Merx J; Maas MN; Langens SGHA; White PB; Boltje TJ; Mecinović J
    Org Biomol Chem; 2021 Dec; 20(1):173-181. PubMed ID: 34877957
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Lysine methyltransferase G9a is required for de novo DNA methylation and the establishment, but not the maintenance, of proviral silencing.
    Leung DC; Dong KB; Maksakova IA; Goyal P; Appanah R; Lee S; Tachibana M; Shinkai Y; Lehnertz B; Mager DL; Rossi F; Lorincz MC
    Proc Natl Acad Sci U S A; 2011 Apr; 108(14):5718-23. PubMed ID: 21427230
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase.
    Butler KV; Ma A; Yu W; Li F; Tempel W; Babault N; Pittella-Silva F; Shao J; Wang J; Luo M; Vedadi M; Brown PJ; Arrowsmith CH; Jin J
    J Med Chem; 2016 Nov; 59(21):9881-9889. PubMed ID: 27804297
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Design, Synthesis, and Biological Activity of Substrate Competitive SMYD2 Inhibitors.
    Cowen SD; Russell D; Dakin LA; Chen H; Larsen NA; Godin R; Throner S; Zheng X; Molina A; Wu J; Cheung T; Howard T; Garcia-Arenas R; Keen N; Pendleton CS; Pietenpol JA; Ferguson AD
    J Med Chem; 2016 Dec; 59(24):11079-11097. PubMed ID: 28002961
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Epidithiodiketopiperazine as a pharmacophore for protein lysine methyltransferase G9a inhibitors: reducing cytotoxicity by structural simplification.
    Fujishiro S; Dodo K; Iwasa E; Teng Y; Sohtome Y; Hamashima Y; Ito A; Yoshida M; Sodeoka M
    Bioorg Med Chem Lett; 2013 Feb; 23(3):733-6. PubMed ID: 23266120
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.