BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

460 related articles for article (PubMed ID: 24652289)

  • 1. Insulin and metabolic stress stimulate multisite serine/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation.
    Hançer NJ; Qiu W; Cherella C; Li Y; Copps KD; White MF
    J Biol Chem; 2014 May; 289(18):12467-84. PubMed ID: 24652289
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase.
    Copps KD; Hançer NJ; Qiu W; White MF
    J Biol Chem; 2016 Apr; 291(16):8602-17. PubMed ID: 26846849
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Prostaglandin F2alpha represses IGF-I-stimulated IRS1/phosphatidylinositol-3-kinase/AKT signaling in the corpus luteum: role of ERK and P70 ribosomal S6 kinase.
    Arvisais E; Hou X; Wyatt TA; Shirasuna K; Bollwein H; Miyamoto A; Hansen TR; Rueda BR; Davis JS
    Mol Endocrinol; 2010 Mar; 24(3):632-43. PubMed ID: 20160123
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Resistin promotes cardiac hypertrophy via the AMP-activated protein kinase/mammalian target of rapamycin (AMPK/mTOR) and c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathways.
    Kang S; Chemaly ER; Hajjar RJ; Lebeche D
    J Biol Chem; 2011 May; 286(21):18465-73. PubMed ID: 21478152
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Phosphorylation of IRS1 at serine 307 in response to insulin in human adipocytes is not likely to be catalyzed by p70 ribosomal S6 kinase.
    Rajan MR; Fagerholm S; Jönsson C; Kjølhede P; Turkina MV; Strålfors P
    PLoS One; 2013; 8(4):e59725. PubMed ID: 23565163
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Phosphorylation of Irs1 at SER-522 inhibits insulin signaling.
    Giraud J; Haas M; Feener EP; Copps KD; Dong X; Dunn SL; White MF
    Mol Endocrinol; 2007 Sep; 21(9):2294-302. PubMed ID: 17579213
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-cells.
    Andreozzi F; D'Alessandris C; Federici M; Laratta E; Del Guerra S; Del Prato S; Marchetti P; Lauro R; Perticone F; Sesti G
    Endocrinology; 2004 Jun; 145(6):2845-57. PubMed ID: 15001544
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation.
    Greene MW; Sakaue H; Wang L; Alessi DR; Roth RA
    J Biol Chem; 2003 Mar; 278(10):8199-211. PubMed ID: 12510059
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Insulin-induced serine phosphorylation of IRS-2 via ERK1/2 and mTOR: studies on the function of Ser675 and Ser907.
    Fritsche L; Neukamm SS; Lehmann R; Kremmer E; Hennige AM; Hunder-Gugel A; Schenk M; Häring HU; Schleicher ED; Weigert C
    Am J Physiol Endocrinol Metab; 2011 May; 300(5):E824-36. PubMed ID: 21098738
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Evodiamine inhibits insulin-stimulated mTOR-S6K activation and IRS1 serine phosphorylation in adipocytes and improves glucose tolerance in obese/diabetic mice.
    Wang T; Kusudo T; Takeuchi T; Yamashita Y; Kontani Y; Okamatsu Y; Saito M; Mori N; Yamashita H
    PLoS One; 2013; 8(12):e83264. PubMed ID: 24391749
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Threonine-120 phosphorylation regulated by phosphoinositide-3-kinase/Akt and mammalian target of rapamycin pathway signaling limits the antitumor activity of mammalian sterile 20-like kinase 1.
    Collak FK; Yagiz K; Luthringer DJ; Erkaya B; Cinar B
    J Biol Chem; 2012 Jul; 287(28):23698-709. PubMed ID: 22619175
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Interplay and effects of temporal changes in the phosphorylation state of serine-302, -307, and -318 of insulin receptor substrate-1 on insulin action in skeletal muscle cells.
    Weigert C; Kron M; Kalbacher H; Pohl AK; Runge H; Häring HU; Schleicher E; Lehmann R
    Mol Endocrinol; 2008 Dec; 22(12):2729-40. PubMed ID: 18927238
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Protein phosphatase 1 regulatory subunit 12A and catalytic subunit δ, new members in the phosphatidylinositide 3 kinase insulin-signaling pathway.
    Geetha T; Langlais P; Caruso M; Yi Z
    J Endocrinol; 2012 Sep; 214(3):437-43. PubMed ID: 22728334
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Different patterns of Akt and ERK feedback activation in response to rapamycin, active-site mTOR inhibitors and metformin in pancreatic cancer cells.
    Soares HP; Ni Y; Kisfalvi K; Sinnett-Smith J; Rozengurt E
    PLoS One; 2013; 8(2):e57289. PubMed ID: 23437362
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 function.
    Paz K; Liu YF; Shorer H; Hemi R; LeRoith D; Quan M; Kanety H; Seger R; Zick Y
    J Biol Chem; 1999 Oct; 274(40):28816-22. PubMed ID: 10497255
    [TBL] [Abstract][Full Text] [Related]  

  • 16. AMP-activated protein kinase inhibits IGF-I signaling and protein synthesis in vascular smooth muscle cells via stimulation of insulin receptor substrate 1 S794 and tuberous sclerosis 2 S1345 phosphorylation.
    Ning J; Clemmons DR
    Mol Endocrinol; 2010 Jun; 24(6):1218-29. PubMed ID: 20363874
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Activation of the cardiac mTOR/p70(S6K) pathway by leucine requires PDK1 and correlates with PRAS40 phosphorylation.
    Sanchez Canedo C; Demeulder B; Ginion A; Bayascas JR; Balligand JL; Alessi DR; Vanoverschelde JL; Beauloye C; Hue L; Bertrand L
    Am J Physiol Endocrinol Metab; 2010 Apr; 298(4):E761-9. PubMed ID: 20051528
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Carrageenan Inhibits Insulin Signaling through GRB10-mediated Decrease in Tyr(P)-IRS1 and through Inflammation-induced Increase in Ser(P)307-IRS1.
    Bhattacharyya S; Feferman L; Tobacman JK
    J Biol Chem; 2015 Apr; 290(17):10764-74. PubMed ID: 25784556
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.
    Ozes ON; Akca H; Mayo LD; Gustin JA; Maehama T; Dixon JE; Donner DB
    Proc Natl Acad Sci U S A; 2001 Apr; 98(8):4640-5. PubMed ID: 11287630
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Chronic inhibition of the mTORC1/S6K1 pathway increases insulin-induced PI3K activity but inhibits Akt2 and glucose transport stimulation in 3T3-L1 adipocytes.
    Veilleux A; Houde VP; Bellmann K; Marette A
    Mol Endocrinol; 2010 Apr; 24(4):766-78. PubMed ID: 20203102
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 23.