BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

258 related articles for article (PubMed ID: 24658003)

  • 1. TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function.
    Gómez-Herreros F; Schuurs-Hoeijmakers JH; McCormack M; Greally MT; Rulten S; Romero-Granados R; Counihan TJ; Chaila E; Conroy J; Ennis S; Delanty N; Cortés-Ledesma F; de Brouwer AP; Cavalleri GL; El-Khamisy SF; de Vries BB; Caldecott KW
    Nat Genet; 2014 May; 46(5):516-21. PubMed ID: 24658003
    [TBL] [Abstract][Full Text] [Related]  

  • 2. TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription.
    Gómez-Herreros F; Zagnoli-Vieira G; Ntai I; Martínez-Macías MI; Anderson RM; Herrero-Ruíz A; Caldecott KW
    Nat Commun; 2017 Aug; 8(1):233. PubMed ID: 28794467
    [TBL] [Abstract][Full Text] [Related]  

  • 3. TDP2 keeps the brain healthy.
    McKinnon PJ
    Nat Genet; 2014 May; 46(5):419-21. PubMed ID: 24769717
    [No Abstract]   [Full Text] [Related]  

  • 4. Depletion of tyrosyl DNA phosphodiesterase 2 activity enhances etoposide-mediated double-strand break formation and cell killing.
    Kont YS; Dutta A; Mallisetty A; Mathew J; Minas T; Kraus C; Dhopeshwarkar P; Kallakury B; Mitra S; Üren A; Adhikari S
    DNA Repair (Amst); 2016 Jul; 43():38-47. PubMed ID: 27235629
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Type II DNA Topoisomerases Cause Spontaneous Double-Strand Breaks in Genomic DNA.
    Morimoto S; Tsuda M; Bunch H; Sasanuma H; Austin C; Takeda S
    Genes (Basel); 2019 Oct; 10(11):. PubMed ID: 31671674
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Effect of TDP2 on the Level of TOP2-DNA Complexes and SUMOylated TOP2-DNA Complexes.
    Lee KC; Swan RL; Sondka Z; Padget K; Cowell IG; Austin CA
    Int J Mol Sci; 2018 Jul; 19(7):. PubMed ID: 30011940
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Physiological concentrations of glucocorticoids induce pathological DNA double-strand breaks.
    Akter S; Shimba A; Ikuta K; Mahmud MRA; Yamada S; Sasanuma H; Tsuda M; Sone M; Ago Y; Murai K; Tanaka H; Takeda S
    Genes Cells; 2023 Jan; 28(1):53-67. PubMed ID: 36415926
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Proteolytic degradation of topoisomerase II (Top2) enables the processing of Top2·DNA and Top2·RNA covalent complexes by tyrosyl-DNA-phosphodiesterase 2 (TDP2).
    Gao R; Schellenberg MJ; Huang SY; Abdelmalak M; Marchand C; Nitiss KC; Nitiss JL; Williams RS; Pommier Y
    J Biol Chem; 2014 Jun; 289(26):17960-9. PubMed ID: 24808172
    [TBL] [Abstract][Full Text] [Related]  

  • 9. TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo.
    Gómez-Herreros F; Romero-Granados R; Zeng Z; Alvarez-Quilón A; Quintero C; Ju L; Umans L; Vermeire L; Huylebroeck D; Caldecott KW; Cortés-Ledesma F
    PLoS Genet; 2013; 9(3):e1003226. PubMed ID: 23505375
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Inactivating TDP2 missense mutation in siblings with congenital abnormalities reminiscent of fanconi anemia.
    Zagnoli-Vieira G; Brazina J; Van Den Bogaert K; Huybrechts W; Molenaers G; Caldecott KW; Van Esch H
    Hum Genet; 2023 Sep; 142(9):1417-1427. PubMed ID: 37558815
    [TBL] [Abstract][Full Text] [Related]  

  • 11. ERK3 regulates TDP2-mediated DNA damage response and chemoresistance in lung cancer cells.
    Bian K; Muppani NR; Elkhadragy L; Wang W; Zhang C; Chen T; Jung S; Seternes OM; Long W
    Oncotarget; 2016 Feb; 7(6):6665-75. PubMed ID: 26701725
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity.
    Canela A; Maman Y; Huang SN; Wutz G; Tang W; Zagnoli-Vieira G; Callen E; Wong N; Day A; Peters JM; Caldecott KW; Pommier Y; Nussenzweig A
    Mol Cell; 2019 Jul; 75(2):252-266.e8. PubMed ID: 31202577
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes.
    Hoa NN; Shimizu T; Zhou ZW; Wang ZQ; Deshpande RA; Paull TT; Akter S; Tsuda M; Furuta R; Tsutsui K; Takeda S; Sasanuma H
    Mol Cell; 2016 Nov; 64(3):580-592. PubMed ID: 27814490
    [TBL] [Abstract][Full Text] [Related]  

  • 14. FEN1 participates in repair of the 5'-phosphotyrosyl terminus of DNA single-strand breaks.
    Kametani Y; Takahata C; Narita T; Tanaka K; Iwai S; Kuraoka I
    Carcinogenesis; 2016 Jan; 37(1):56-62. PubMed ID: 26581212
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Dual functions of the homeoprotein DLX4 in modulating responsiveness of tumor cells to topoisomerase II-targeting drugs.
    Trinh BQ; Ko SY; Barengo N; Lin SY; Naora H
    Cancer Res; 2013 Jan; 73(2):1000-10. PubMed ID: 23222298
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.
    Schellenberg MJ; Perera L; Strom CN; Waters CA; Monian B; Appel CD; Vilas CK; Williams JG; Ramsden DA; Williams RS
    Nucleic Acids Res; 2016 May; 44(8):3829-44. PubMed ID: 27060144
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage.
    Cortes Ledesma F; El Khamisy SF; Zuma MC; Osborn K; Caldecott KW
    Nature; 2009 Oct; 461(7264):674-8. PubMed ID: 19794497
    [TBL] [Abstract][Full Text] [Related]  

  • 18. TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.
    Zeng Z; Sharma A; Ju L; Murai J; Umans L; Vermeire L; Pommier Y; Takeda S; Huylebroeck D; Caldecott KW; El-Khamisy SF
    Nucleic Acids Res; 2012 Sep; 40(17):8371-80. PubMed ID: 22740648
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Novel TDP2-ubiquitin interactions and their importance for the repair of topoisomerase II-mediated DNA damage.
    Rao T; Gao R; Takada S; Al Abo M; Chen X; Walters KJ; Pommier Y; Aihara H
    Nucleic Acids Res; 2016 Dec; 44(21):10201-10215. PubMed ID: 27543075
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Untangling trapped topoisomerases with tyrosyl-DNA phosphodiesterases.
    Zagnoli-Vieira G; Caldecott KW
    DNA Repair (Amst); 2020 Oct; 94():102900. PubMed ID: 32653827
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.