BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

174 related articles for article (PubMed ID: 24676659)

  • 1. Megazol and its bioisostere 4H-1,2,4-triazole: comparing the trypanocidal, cytotoxic and genotoxic activities and their in vitro and in silico interactions with the Trypanosoma brucei nitroreductase enzyme.
    Carvalho AS; Salomão K; Castro SL; Conde TR; Zamith HP; Caffarena ER; Hall BS; Wilkinson SR; Boechat N
    Mem Inst Oswaldo Cruz; 2014 Jun; 109(3):315-23. PubMed ID: 24676659
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
    Chauvière G; Bouteille B; Enanga B; de Albuquerque C; Croft SL; Dumas M; Périé J
    J Med Chem; 2003 Jan; 46(3):427-40. PubMed ID: 12540242
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Novel 3-nitro-1H-1,2,4-triazole-based amides and sulfonamides as potential antitrypanosomal agents.
    Papadopoulou MV; Bloomer WD; Rosenzweig HS; Chatelain E; Kaiser M; Wilkinson SR; McKenzie C; Ioset JR
    J Med Chem; 2012 Jun; 55(11):5554-65. PubMed ID: 22550999
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Novel 3-nitro-1H-1,2,4-triazole-based piperazines and 2-amino-1,3-benzothiazoles as antichagasic agents.
    Papadopoulou MV; Bloomer WD; Rosenzweig HS; Kaiser M; Chatelain E; Ioset JR
    Bioorg Med Chem; 2013 Nov; 21(21):6600-7. PubMed ID: 24012457
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Exploiting the drug-activating properties of a novel trypanosomal nitroreductase.
    Hall BS; Wu X; Hu L; Wilkinson SR
    Antimicrob Agents Chemother; 2010 Mar; 54(3):1193-9. PubMed ID: 20028822
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and antitrypanosomal profile of new functionalized 1,3,4-thiadiazole-2-arylhydrazone derivatives, designed as non-mutagenic megazol analogues.
    Carvalho SA; da Silva EF; Santa-Rita RM; de Castro SL; Fraga CA
    Bioorg Med Chem Lett; 2004 Dec; 14(24):5967-70. PubMed ID: 15546709
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Targeting the substrate preference of a type I nitroreductase to develop antitrypanosomal quinone-based prodrugs.
    Hall BS; Meredith EL; Wilkinson SR
    Antimicrob Agents Chemother; 2012 Nov; 56(11):5821-30. PubMed ID: 22948871
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Novel 3-nitro-1H-1,2,4-triazole-based aliphatic and aromatic amines as anti-chagasic agents.
    Papadopoulou MV; Trunz BB; Bloomer WD; McKenzie C; Wilkinson SR; Prasittichai C; Brun R; Kaiser M; Torreele E
    J Med Chem; 2011 Dec; 54(23):8214-23. PubMed ID: 22023653
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Activity of megazol, a trypanocidal nitroimidazole, is associated with DNA damage.
    Enanga B; Ariyanayagam MR; Stewart ML; Barrett MP
    Antimicrob Agents Chemother; 2003 Oct; 47(10):3368-70. PubMed ID: 14506061
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of potent nitrotriazole-based antitrypanosomal agents: In vitro and in vivo evaluation.
    Papadopoulou MV; Bloomer WD; Rosenzweig HS; O'Shea IP; Wilkinson SR; Kaiser M; Chatelain E; Ioset JR
    Bioorg Med Chem; 2015 Oct; 23(19):6467-76. PubMed ID: 26344593
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Anti-
    Menozzi CAC; França RRF; Luccas PH; Baptista MDS; Fernandes TVA; Hoelz LVB; Sales Junior PA; Murta SMF; Romanha A; Galvão BVD; Macedo MO; Goldstein ADC; Araujo-Lima CF; Felzenszwalb I; Nonato MC; Castelo-Branco FS; Boechat N
    Molecules; 2023 Nov; 28(22):. PubMed ID: 38005183
    [TBL] [Abstract][Full Text] [Related]  

  • 12. In vitro genotoxicity of nitroimidazoles as a tool in the search of new trypanocidal agents.
    Von Trompowsky ACM; Conde TR; Lemos RC; Quaresma BMC; Pitombeira MCS; de Carvalho AS; Boechat N; Salomão K; de Castro SL; Zamith HPDS
    Mem Inst Oswaldo Cruz; 2019; 114():e190017. PubMed ID: 31271593
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Effect of megazol on Trypanosoma brucei brucei acute and subacute infections in Swiss mice.
    Bouteille B; Marie-Daragon A; Chauvière G; de Albuquerque C; Enanga B; Dardé ML; Vallat JM; Périé J; Dumas M
    Acta Trop; 1995 Oct; 60(2):73-80. PubMed ID: 8610542
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Novel nitroimidazole derivatives evaluated for their trypanocidal, cytotoxic, and genotoxic activities.
    do Vale Chaves E Mello F; Castro Salomão Quaresma BM; Resende Pitombeira MC; Araújo de Brito M; Farias PP; Lisboa de Castro S; Salomão K; Silva de Carvalho A; Oliveira de Paula JI; de Brito Nascimento S; Peixoto Cupello M; Paes MC; Boechat N; Felzenszwalb I
    Eur J Med Chem; 2020 Jan; 186():111887. PubMed ID: 31787363
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Evaluating 5-nitrofurans as trypanocidal agents.
    Bot C; Hall BS; Alvarez G; Di Maio R; González M; Cerecetto H; Wilkinson SR
    Antimicrob Agents Chemother; 2013 Apr; 57(4):1638-47. PubMed ID: 23335745
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs.
    Meredith EL; Kumar A; Konno A; Szular J; Alsford S; Seifert K; Horn D; Wilkinson SR
    Mol Microbiol; 2017 Oct; 106(2):207-222. PubMed ID: 28792090
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Antikinetoplastid SAR study in 3-nitroimidazopyridine series: Identification of a novel non-genotoxic and potent anti-T. b. brucei hit-compound with improved pharmacokinetic properties.
    Fersing C; Boudot C; Paoli-Lombardo R; Primas N; Pinault E; Hutter S; Castera-Ducros C; Kabri Y; Pedron J; Bourgeade-Delmas S; Sournia-Saquet A; Stigliani JL; Valentin A; Azqueta A; Muruzabal D; Destere A; Wyllie S; Fairlamb AH; Corvaisier S; Since M; Malzert-Fréon A; Di Giorgio C; Rathelot P; Azas N; Courtioux B; Vanelle P; Verhaeghe P
    Eur J Med Chem; 2020 Nov; 206():112668. PubMed ID: 32795774
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Activation of benznidazole by trypanosomal type I nitroreductases results in glyoxal formation.
    Hall BS; Wilkinson SR
    Antimicrob Agents Chemother; 2012 Jan; 56(1):115-23. PubMed ID: 22037852
    [TBL] [Abstract][Full Text] [Related]  

  • 19. 8-Alkynyl-3-nitroimidazopyridines display potent antitrypanosomal activity against both T. b. brucei and cruzi.
    Fersing C; Boudot C; Castera-Ducros C; Pinault E; Hutter S; Paoli-Lombardo R; Primas N; Pedron J; Seguy L; Bourgeade-Delmas S; Sournia-Saquet A; Stigliani JL; Brossas JY; Paris L; Valentin A; Wyllie S; Fairlamb AH; Boutet-Robinet É; Corvaisier S; Since M; Malzert-Fréon A; Destere A; Mazier D; Rathelot P; Courtioux B; Azas N; Verhaeghe P; Vanelle P
    Eur J Med Chem; 2020 Sep; 202():112558. PubMed ID: 32652409
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Evaluating 5-Nitrothiazoles as Trypanocidal Agents.
    O'Shea IP; Shahed M; Aguilera-Venegas B; Wilkinson SR
    Antimicrob Agents Chemother; 2016 Feb; 60(2):1137-40. PubMed ID: 26596950
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.