These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

171 related articles for article (PubMed ID: 24681980)

  • 1. Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease.
    Belluti F; De Simone A; Tarozzi A; Bartolini M; Djemil A; Bisi A; Gobbi S; Montanari S; Cavalli A; Andrisano V; Bottegoni G; Rampa A
    Eur J Med Chem; 2014 May; 78():157-66. PubMed ID: 24681980
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Multipotent AChE and BACE-1 inhibitors for the treatment of Alzheimer's disease: Design, synthesis and bio-analysis of 7-amino-1,4-dihydro-2H-isoquilin-3-one derivates.
    Zhao XJ; Gong DM; Jiang YR; Guo D; Zhu Y; Deng YC
    Eur J Med Chem; 2017 Sep; 138():738-747. PubMed ID: 28728106
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Benzophenone-based derivatives: a novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
    Belluti F; Bartolini M; Bottegoni G; Bisi A; Cavalli A; Andrisano V; Rampa A
    Eur J Med Chem; 2011 May; 46(5):1682-93. PubMed ID: 21397996
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and beta-secretase.
    Zhu Y; Xiao K; Ma L; Xiong B; Fu Y; Yu H; Wang W; Wang X; Hu D; Peng H; Li J; Gong Q; Chai Q; Tang X; Zhang H; Li J; Shen J
    Bioorg Med Chem; 2009 Feb; 17(4):1600-13. PubMed ID: 19162488
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Syntheses of coumarin-tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, Aβ aggregation, and β-secretase.
    Sun Q; Peng DY; Yang SG; Zhu XL; Yang WC; Yang GF
    Bioorg Med Chem; 2014 Sep; 22(17):4784-91. PubMed ID: 25088549
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design, synthesis and biological evaluation of 2-acetyl-5-O-(amino-alkyl)phenol derivatives as multifunctional agents for the treatment of Alzheimer's disease.
    Sang Z; Wang K; Wang H; Wang H; Ma Q; Han X; Ye M; Yu L; Liu W
    Bioorg Med Chem Lett; 2017 Nov; 27(22):5046-5052. PubMed ID: 29033233
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of β-secretase (BACE).
    Boy KM; Guernon JM; Shi J; Toyn JH; Meredith JE; Barten DM; Burton CR; Albright CF; Marcinkeviciene J; Good AC; Tebben AJ; Muckelbauer JK; Camac DM; Lentz KA; Bronson JJ; Olson RE; Macor JE; Thompson LA
    Bioorg Med Chem Lett; 2011 Nov; 21(22):6916-24. PubMed ID: 21782431
    [TBL] [Abstract][Full Text] [Related]  

  • 8. New neurogenic lipoic-based hybrids as innovative Alzheimer's drugs with σ-1 agonism and β-secretase inhibition.
    Estrada M; Pérez C; Soriano E; Laurini E; Romano M; Pricl S; Morales-García JA; Pérez-Castillo A; Rodríguez-Franco MI
    Future Med Chem; 2016 Jul; 8(11):1191-207. PubMed ID: 27402296
    [TBL] [Abstract][Full Text] [Related]  

  • 9. New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, and β-amyloid-reducing properties.
    Fernández-Bachiller MI; Pérez C; Monjas L; Rademann J; Rodríguez-Franco MI
    J Med Chem; 2012 Feb; 55(3):1303-17. PubMed ID: 22243648
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Fluoro-benzimidazole derivatives to cure Alzheimer's disease: In-silico studies, synthesis, structure-activity relationship and in vivo evaluation for β secretase enzyme inhibition.
    Ali S; Asad MHHB; Maity S; Zada W; Rizvanov AA; Iqbal J; Babak B; Hussain I
    Bioorg Chem; 2019 Jul; 88():102936. PubMed ID: 31054426
    [No Abstract]   [Full Text] [Related]  

  • 11. Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease.
    Mayer SC; Kreft AF; Harrison B; Abou-Gharbia M; Antane M; Aschmies S; Atchison K; Chlenov M; Cole DC; Comery T; Diamantidis G; Ellingboe J; Fan K; Galante R; Gonzales C; Ho DM; Hoke ME; Hu Y; Huryn D; Jain U; Jin M; Kremer K; Kubrak D; Lin M; Lu P; Magolda R; Martone R; Moore W; Oganesian A; Pangalos MN; Porte A; Reinhart P; Resnick L; Riddell DR; Sonnenberg-Reines J; Stock JR; Sun SC; Wagner E; Wang T; Woller K; Xu Z; Zaleska MM; Zeldis J; Zhang M; Zhou H; Jacobsen JS
    J Med Chem; 2008 Dec; 51(23):7348-51. PubMed ID: 19012391
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Dual inhibitors of β-amyloid aggregation and acetylcholinesterase as multi-target anti-Alzheimer drug candidates.
    Viayna E; Sabate R; Muñoz-Torrero D
    Curr Top Med Chem; 2013; 13(15):1820-42. PubMed ID: 23931440
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design, Synthesis, and Biological Evaluation of 2-(Benzylamino-2-Hydroxyalkyl)Isoindoline-1,3-Diones Derivatives as Potential Disease-Modifying Multifunctional Anti-Alzheimer Agents.
    Panek D; Więckowska A; Pasieka A; Godyń J; Jończyk J; Bajda M; Knez D; Gobec S; Malawska B
    Molecules; 2018 Feb; 23(2):. PubMed ID: 29414887
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors.
    Belluti F; Piazzi L; Bisi A; Gobbi S; Bartolini M; Cavalli A; Valenti P; Rampa A
    Eur J Med Chem; 2009 Mar; 44(3):1341-8. PubMed ID: 18396354
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Searching for the Multi-Target-Directed Ligands against Alzheimer's disease: discovery of quinoxaline-based hybrid compounds with AChE, H₃R and BACE 1 inhibitory activities.
    Huang W; Tang L; Shi Y; Huang S; Xu L; Sheng R; Wu P; Li J; Zhou N; Hu Y
    Bioorg Med Chem; 2011 Dec; 19(23):7158-67. PubMed ID: 22019465
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design, synthesis, and evaluation of tetrahydroquinoline and pyrrolidine sulfonamide carbamates as gamma-secretase inhibitors.
    Guo T; Gu H; Hobbs DW; Rokosz LL; Stauffer TM; Jacob B; Clader JW
    Bioorg Med Chem Lett; 2007 Jun; 17(11):3010-3. PubMed ID: 17418571
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Design, synthesis, characterization and biological evaluation of novel pyrazole integrated benzophenones.
    Bandgar BP; Chavan HV; Adsul LK; Thakare VN; Shringare SN; Shaikh R; Gacche RN
    Bioorg Med Chem Lett; 2013 Feb; 23(3):912-6. PubMed ID: 23290048
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis and antioxidant potential of novel synthetic benzophenone analogues.
    Tzanova T; Gerova M; Petrov O; Karaivanova M; Bagrel D
    Eur J Med Chem; 2009 Jun; 44(6):2724-30. PubMed ID: 18950902
    [TBL] [Abstract][Full Text] [Related]  

  • 19. O-Hydroxyl- or o-amino benzylamine-tacrine hybrids: multifunctional biometals chelators, antioxidants, and inhibitors of cholinesterase activity and amyloid-β aggregation.
    Mao F; Huang L; Luo Z; Liu A; Lu C; Xie Z; Li X
    Bioorg Med Chem; 2012 Oct; 20(19):5884-92. PubMed ID: 22944335
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Semi-synthetic isoflavones as BACE-1 inhibitors against Alzheimer's disease.
    Ribaudo G; Coghi P; Zanforlin E; Law BYK; Wu YYJ; Han Y; Qiu AC; Qu YQ; Zagotto G; Wong VKW
    Bioorg Chem; 2019 Jun; 87():474-483. PubMed ID: 30927588
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.