262 related articles for article (PubMed ID: 24703948)
1. Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt.
Wang P; Zhou Z; Hu A; Ponte de Albuquerque C; Zhou Y; Hong L; Sierecki E; Ajiro M; Kruhlak M; Harris C; Guan KL; Zheng ZM; Newton AC; Sun P; Zhou H; Fu XD
Mol Cell; 2014 May; 54(3):378-91. PubMed ID: 24703948
[TBL] [Abstract][Full Text] [Related]
2. Akt-ing up on SRPK1: oncogene or tumor suppressor?
Toker A; Chin YR
Mol Cell; 2014 May; 54(3):329-30. PubMed ID: 24813709
[TBL] [Abstract][Full Text] [Related]
3. Pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP): a new player in cell signaling.
Warfel NA; Newton AC
J Biol Chem; 2012 Feb; 287(6):3610-6. PubMed ID: 22144674
[TBL] [Abstract][Full Text] [Related]
4. PHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in mice.
Li X; Stevens PD; Liu J; Yang H; Wang W; Wang C; Zeng Z; Schmidt MD; Yang M; Lee EY; Gao T
Gastroenterology; 2014 May; 146(5):1301-12.e1-10. PubMed ID: 24530606
[TBL] [Abstract][Full Text] [Related]
5. SRPK1 contributes to malignancy of hepatocellular carcinoma through a possible mechanism involving PI3K/Akt.
Zhou B; Li Y; Deng Q; Wang H; Wang Y; Cai B; Han ZG
Mol Cell Biochem; 2013 Jul; 379(1-2):191-9. PubMed ID: 23644876
[TBL] [Abstract][Full Text] [Related]
6. Vitamin E facilitates the inactivation of the kinase Akt by the phosphatase PHLPP1.
Huang PH; Chuang HC; Chou CC; Wang H; Lee SL; Yang HC; Chiu HC; Kapuriya N; Wang D; Kulp SK; Chen CS
Sci Signal; 2013 Mar; 6(267):ra19. PubMed ID: 23512990
[TBL] [Abstract][Full Text] [Related]
7. Photoreceptor Neuroprotection: Regulation of Akt Activation Through Serine/Threonine Phosphatases, PHLPP and PHLPPL.
Rajala RV; Kanan Y; Anderson RE
Adv Exp Med Biol; 2016; 854():419-24. PubMed ID: 26427440
[TBL] [Abstract][Full Text] [Related]
8. Phosphorylation of SRSF1 by SRPK1 regulates alternative splicing of tumor-related Rac1b in colorectal cells.
Gonçalves V; Henriques AF; Pereira JF; Neves Costa A; Moyer MP; Moita LF; Gama-Carvalho M; Matos P; Jordan P
RNA; 2014 Apr; 20(4):474-82. PubMed ID: 24550521
[TBL] [Abstract][Full Text] [Related]
9. Turning off AKT: PHLPP as a drug target.
Newton AC; Trotman LC
Annu Rev Pharmacol Toxicol; 2014; 54():537-58. PubMed ID: 24392697
[TBL] [Abstract][Full Text] [Related]
10. Diacylglycerol kinase δ modulates Akt phosphorylation through pleckstrin homology domain leucine-rich repeat protein phosphatase 2 (PHLPP2).
Crotty TM; Nakano T; Stafforini DM; Topham MK
J Biol Chem; 2013 Jan; 288(3):1439-47. PubMed ID: 23184957
[TBL] [Abstract][Full Text] [Related]
11. Physiological activation of Akt by PHLPP1 deletion protects against pathological hypertrophy.
Moc C; Taylor AE; Chesini GP; Zambrano CM; Barlow MS; Zhang X; Gustafsson ÅB; Purcell NH
Cardiovasc Res; 2015 Feb; 105(2):160-70. PubMed ID: 25411382
[TBL] [Abstract][Full Text] [Related]
12. The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer.
Li X; Stevens PD; Yang H; Gulhati P; Wang W; Evers BM; Gao T
Oncogene; 2013 Jan; 32(4):471-8. PubMed ID: 22391563
[TBL] [Abstract][Full Text] [Related]
13. The phosphatase PHLPP1 regulates Akt2, promotes pancreatic cancer cell death, and inhibits tumor formation.
Nitsche C; Edderkaoui M; Moore RM; Eibl G; Kasahara N; Treger J; Grippo PJ; Mayerle J; Lerch MM; Gukovskaya AS
Gastroenterology; 2012 Feb; 142(2):377-87.e1-5. PubMed ID: 22044669
[TBL] [Abstract][Full Text] [Related]
14. P2 × 7 Receptor Inhibits Astroglial Autophagy via Regulating FAK- and PHLPP1/2-Mediated AKT-S473 Phosphorylation Following Kainic Acid-Induced Seizures.
Lee DS; Kim JE
Int J Mol Sci; 2020 Sep; 21(18):. PubMed ID: 32899862
[TBL] [Abstract][Full Text] [Related]
15. PHLPPing through history: a decade in the life of PHLPP phosphatases.
Grzechnik AT; Newton AC
Biochem Soc Trans; 2016 Dec; 44(6):1675-1682. PubMed ID: 27913677
[TBL] [Abstract][Full Text] [Related]
16. Pleckstrin Homology (PH) Domain Leucine-rich Repeat Protein Phosphatase Controls Cell Polarity by Negatively Regulating the Activity of Atypical Protein Kinase C.
Xiong X; Li X; Wen YA; Gao T
J Biol Chem; 2016 Nov; 291(48):25167-25178. PubMed ID: 27760826
[TBL] [Abstract][Full Text] [Related]
17. Mislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt.
Warfel NA; Niederst M; Stevens MW; Brennan PM; Frame MC; Newton AC
J Biol Chem; 2011 Jun; 286(22):19777-88. PubMed ID: 21454620
[TBL] [Abstract][Full Text] [Related]
18. Exploitation of the ability of γ-tocopherol to facilitate membrane co-localization of Akt and PHLPP1 to develop PHLPP1-targeted Akt inhibitors.
Yan R; Chuang HC; Kapuriya N; Chou CC; Lai PT; Chang HW; Yang CN; Kulp SK; Chen CS
J Med Chem; 2015 Mar; 58(5):2290-8. PubMed ID: 25689347
[TBL] [Abstract][Full Text] [Related]
19. Greatwall promotes cell transformation by hyperactivating AKT in human malignancies.
Vera J; Lartigue L; Vigneron S; Gadea G; Gire V; Del Rio M; Soubeyran I; Chibon F; Lorca T; Castro A
Elife; 2015 Nov; 4():. PubMed ID: 26613407
[TBL] [Abstract][Full Text] [Related]
20. Depletion of Pleckstrin homology domain leucine-rich repeat protein phosphatases 1 and 2 by Bcr-Abl promotes chronic myelogenous leukemia cell proliferation through continuous phosphorylation of Akt isoforms.
Hirano I; Nakamura S; Yokota D; Ono T; Shigeno K; Fujisawa S; Shinjo K; Ohnishi K
J Biol Chem; 2009 Aug; 284(33):22155-22165. PubMed ID: 19261608
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
