BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

147 related articles for article (PubMed ID: 2470749)

  • 1. Methenyltetrahydrofolate synthetase prevents the inhibition of phosphoribosyl 5-aminoimidazole 4-carboxamide ribonucleotide formyltransferase by 5-formyltetrahydrofolate polyglutamates.
    Bertrand R; Jolivet J
    J Biol Chem; 1989 May; 264(15):8843-6. PubMed ID: 2470749
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase, adenosine deaminase and 5'-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide.
    Baggott JE; Vaughn WH; Hudson BB
    Biochem J; 1986 May; 236(1):193-200. PubMed ID: 2431676
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Evidence for direct inhibition of de novo purine synthesis in human MCF-7 breast cells as a principal mode of metabolic inhibition by methotrexate.
    Allegra CJ; Hoang K; Yeh GC; Drake JC; Baram J
    J Biol Chem; 1987 Oct; 262(28):13520-6. PubMed ID: 2443493
    [TBL] [Abstract][Full Text] [Related]  

  • 4. LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes.
    Shih C; Chen VJ; Gossett LS; Gates SB; MacKellar WC; Habeck LL; Shackelford KA; Mendelsohn LG; Soose DJ; Patel VF; Andis SL; Bewley JR; Rayl EA; Moroson BA; Beardsley GP; Kohler W; Ratnam M; Schultz RM
    Cancer Res; 1997 Mar; 57(6):1116-23. PubMed ID: 9067281
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates.
    Allegra CJ; Drake JC; Jolivet J; Chabner BA
    Proc Natl Acad Sci U S A; 1985 Aug; 82(15):4881-5. PubMed ID: 3860829
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Human liver methenyltetrahydrofolate synthetase: improved purification and increased affinity for folate polyglutamate substrates.
    Bertrand R; MacKenzie RE; Jolivet J
    Biochim Biophys Acta; 1987 Jan; 911(2):154-61. PubMed ID: 3801490
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identification and biochemical properties of 10-formyldihydrofolate, a novel folate found in methotrexate-treated cells.
    Baram J; Chabner BA; Drake JC; Fitzhugh AL; Sholar PW; Allegra CJ
    J Biol Chem; 1988 May; 263(15):7105-11. PubMed ID: 3366769
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Inhibition of glycinamide ribonucleotide formyltransferase and other folate enzymes by homofolate polyglutamates in human lymphoma and murine leukemia cell extracts.
    Thorndike J; Gaumont Y; Kisliuk RL; Sirotnak FM; Murthy BR; Nair MG; Piper JR
    Cancer Res; 1989 Jan; 49(1):158-63. PubMed ID: 2521177
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Biochemical and biological studies on 2-desamino-2-methylaminopterin, an antifolate the polyglutamates of which are more potent than the monoglutamate against three key enzymes of folate metabolism.
    Rosowsky A; Galivan J; Beardsley GP; Bader H; O'Connor BM; Russello O; Moroson BA; DeYarman MT; Kerwar SS; Freisheim JH
    Cancer Res; 1992 Apr; 52(8):2148-55. PubMed ID: 1313737
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Cofactor role for 10-formyldihydrofolic acid.
    Baggott JE; Johanning GL; Branham KE; Prince CW; Morgan SL; Eto I; Vaughn WH
    Biochem J; 1995 Jun; 308 ( Pt 3)(Pt 3):1031-6. PubMed ID: 8948466
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Evidence that the folate-requiring enzymes of de novo purine biosynthesis are encoded by individual mRNAs.
    Wasserman GF; Mueller WT; Benkovic SJ; Liao WS; Taylor J
    Biochemistry; 1984 Dec; 23(26):6704-10. PubMed ID: 6335666
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Inhibition of chicken liver 5-aminoimidazole-4-carboxamide ribonucleotide transformylase by 5,8-dideaza analogues of folic acid.
    Mueller WT; Smith GK; Benkovic SJ; Hynes JB
    Biochem Pharmacol; 1988 Feb; 37(3):449-51. PubMed ID: 3337744
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis of 5,11-methenyltetrahydrohomofolate and its antifolate activity in vitro.
    Caperelli CA; Domanico P; Benkovic SJ
    J Med Chem; 1981 Sep; 24(9):1086-8. PubMed ID: 7288824
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Antifolates induce primary inhibition of the de novo purine pathway prior to 5-aminoimidazole-4-carboxamide ribotide transformylase in leukemia cells.
    Lyons SD; Christopherson RI
    Biochem Int; 1991 May; 24(1):187-97. PubMed ID: 1768258
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A multifunctional protein possessing glycinamide ribonucleotide synthetase, glycinamide ribonucleotide transformylase, and aminoimidazole ribonucleotide synthetase activities in de novo purine biosynthesis.
    Daubner SC; Schrimsher JL; Schendel FJ; Young M; Henikoff S; Patterson D; Stubbe J; Benkovic SJ
    Biochemistry; 1985 Dec; 24(25):7059-62. PubMed ID: 4084560
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Inhibition of HKSV28 cell growth by 5,11-methenyl-tetrahydrohomofolate.
    Slieker LJ; Benkovic SJ
    Mol Pharmacol; 1984 Mar; 25(2):294-302. PubMed ID: 6700575
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mammalian glycinamide ribonucleotide transformylase. Kinetic mechanism and associated de novo purine biosynthetic activities.
    Caperelli CA
    J Biol Chem; 1989 Mar; 264(9):5053-7. PubMed ID: 2925682
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Tight binding of folate substrates and inhibitors to recombinant mouse glycinamide ribonucleotide formyltransferase.
    Sanghani SP; Moran RG
    Biochemistry; 1997 Aug; 36(34):10506-16. PubMed ID: 9265631
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway.
    Desharnais J; Hwang I; Zhang Y; Tavassoli A; Baboval J; Benkovic SJ; Wilson IA; Boger DL
    Bioorg Med Chem; 2003 Oct; 11(20):4511-21. PubMed ID: 13129587
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Nucleotide sequence analysis of genes purH and purD involved in the de novo purine nucleotide biosynthesis of Escherichia coli.
    Aiba A; Mizobuchi K
    J Biol Chem; 1989 Dec; 264(35):21239-46. PubMed ID: 2687276
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.