BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

309 related articles for article (PubMed ID: 24737574)

  • 1. Design, synthesis, and activity evaluation of GK/PPARγ dual-target-directed ligands as hypoglycemic agents.
    Lu J; Lei L; Huan Y; Li Y; Zhang L; Shen Z; Hu W; Feng Z
    ChemMedChem; 2014 May; 9(5):922-7. PubMed ID: 24737574
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of novel urea derivatives as dual-target hypoglycemic agents that activate glucokinase and PPARγ.
    Li Y; Tian K; Qin A; Zhang L; Huo L; Lei L; Shen Z; Song H; Feng Z
    Eur J Med Chem; 2014 Apr; 76():182-92. PubMed ID: 24583379
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Design, development and evaluation of novel dual PPARδ/PPARγ agonists.
    Gathiaka S; Nanayakkara G; Boncher T; Acevedo O; Wyble J; Patel S; Patel A; Shane ME; Bonkowski B; Wieczorek J; Rong Y; Huggins K; Smith F; Amin RH
    Bioorg Med Chem Lett; 2013 Feb; 23(3):873-9. PubMed ID: 23273519
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design, synthesis, and biological evaluation of novel thiazolidinediones as PPARγ/FFAR1 dual agonists.
    Darwish KM; Salama I; Mostafa S; Gomaa MS; Helal MA
    Eur J Med Chem; 2016 Feb; 109():157-72. PubMed ID: 26774923
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Benzimidazolones: a new class of selective peroxisome proliferator-activated receptor γ (PPARγ) modulators.
    Liu W; Lau F; Liu K; Wood HB; Zhou G; Chen Y; Li Y; Akiyama TE; Castriota G; Einstein M; Wang C; McCann ME; Doebber TW; Wu M; Chang CH; McNamara L; McKeever B; Mosley RT; Berger JP; Meinke PT
    J Med Chem; 2011 Dec; 54(24):8541-54. PubMed ID: 22070604
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design and synthesis of 6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid derivatives as PPARgamma activators.
    Kumar R; Mittal A; Ramachandran U
    Bioorg Med Chem Lett; 2007 Aug; 17(16):4613-8. PubMed ID: 17574414
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists.
    Lin CH; Peng YH; Coumar MS; Chittimalla SK; Liao CC; Lyn PC; Huang CC; Lien TW; Lin WH; Hsu JT; Cheng JH; Chen X; Wu JS; Chao YS; Lee HJ; Juo CG; Wu SY; Hsieh HP
    J Med Chem; 2009 Apr; 52(8):2618-22. PubMed ID: 19301897
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Development of docking-based 3D-QSAR models for PPARgamma full agonists.
    Guasch L; Sala E; Valls C; Mulero M; Pujadas G; Garcia-Vallvé S
    J Mol Graph Model; 2012 Jun; 36():1-9. PubMed ID: 22503857
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARα/γ agonists.
    Zhang H; Ding CZ; Lai Z; Chen SS; Devasthale P; Herpin T; Morton G; Qu F; Ryono D; Smirk R; Wang W; Wu S; Ye XX; Li YX; Apedo A; Farrelly D; Wang T; Gu L; Morgan N; Flynn N; Chu C; Kunselman L; Lippy J; Locke K; O'Malley K; Harrity T; Cap M; Zhang L; Hosagrahara V; Kadiyala P; Xu C; Doweyko AM; Zahler R; Hariharan N; Cheng PT
    Bioorg Med Chem Lett; 2015 Mar; 25(6):1196-205. PubMed ID: 25686852
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of novel dual-action antidiabetic agents that inhibit glycogen phosphorylase and activate glucokinase.
    Zhang L; Chen X; Liu J; Zhu Q; Leng Y; Luo X; Jiang H; Liu H
    Eur J Med Chem; 2012 Dec; 58():624-39. PubMed ID: 23178962
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Benzamide derivatives as dual-action hypoglycemic agents that inhibit glycogen phosphorylase and activate glucokinase.
    Zhang L; Li H; Zhu Q; Liu J; Chen L; Leng Y; Jiang H; Liu H
    Bioorg Med Chem; 2009 Oct; 17(20):7301-12. PubMed ID: 19758809
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design, synthesis, molecular modeling and anti-hyperglycemic evaluation of quinazolin-4(3H)-one derivatives as potential PPARγ and SUR agonists.
    Ibrahim MK; Eissa IH; Alesawy MS; Metwaly AM; Radwan MM; ElSohly MA
    Bioorg Med Chem; 2017 Sep; 25(17):4723-4744. PubMed ID: 28720328
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design, synthesis and biological evaluation of novel thiazol-2-yl benzamide derivatives as glucokinase activators.
    Charaya N; Pandita D; Grewal AS; Lather V
    Comput Biol Chem; 2018 Apr; 73():221-229. PubMed ID: 29518630
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis of docosahexaenoic acid derivatives designed as novel PPARgamma agonists and antidiabetic agents.
    Itoh T; Murota I; Yoshikai K; Yamada S; Yamamoto K
    Bioorg Med Chem; 2006 Jan; 14(1):98-108. PubMed ID: 16198578
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Targeting glucokinase activation for the treatment of type 2 diabetes--a status review.
    Sarabu R; Grimsby J
    Curr Opin Drug Discov Devel; 2005 Sep; 8(5):631-7. PubMed ID: 16159025
    [TBL] [Abstract][Full Text] [Related]  

  • 16. [Design, synthesis, and PPARalpha/gamma agonistic activity of novel tetrahydroisoquinoline derivatives].
    Yu R; Zhou YL; Huan Y; Liu Q; Shen ZF; Liu ZZ
    Yao Xue Xue Bao; 2011 Mar; 46(3):311-6. PubMed ID: 21626786
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Design, synthesis, and biological evaluation of novel pan agonists of FFA1, PPARγ and PPARδ.
    Li Z; Zhou Z; Deng F; Li Y; Zhang D; Zhang L
    Eur J Med Chem; 2018 Nov; 159():267-276. PubMed ID: 30296685
    [TBL] [Abstract][Full Text] [Related]  

  • 18. [Salicylic acid derivatives as simplified and novel GK small molecule activators].
    Huo LC; Zhang YL; Lei L; Liu SN; Shen ZF; Wang YL; Song HR; Feng ZQ
    Yao Xue Xue Bao; 2013 Apr; 48(4):514-20. PubMed ID: 23833938
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Sulfonylthiadiazoles with an unusual binding mode as partial dual peroxisome proliferator-activated receptor (PPAR) γ/δ agonists with high potency and in vivo efficacy.
    Keil S; Matter H; Schönafinger K; Glien M; Mathieu M; Marquette JP; Michot N; Haag-Diergarten S; Urmann M; Wendler W
    ChemMedChem; 2011 Apr; 6(4):633-53. PubMed ID: 21400663
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Design, synthesis, and structure-activity relationship studies of novel 2,4,6-trisubstituted-5-pyrimidinecarboxylic acids as peroxisome proliferator-activated receptor gamma (PPARgamma) partial agonists with comparable antidiabetic efficacy to rosiglitazone.
    Seto S; Okada K; Kiyota K; Isogai S; Iwago M; Shinozaki T; Kitamura Y; Kohno Y; Murakami K
    J Med Chem; 2010 Jul; 53(13):5012-24. PubMed ID: 20527969
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.