These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

282 related articles for article (PubMed ID: 24760825)

  • 1. E3 ubiquitin ligase Cullin-5 modulates multiple molecular and cellular responses to heat shock protein 90 inhibition in human cancer cells.
    Samant RS; Clarke PA; Workman P
    Proc Natl Acad Sci U S A; 2014 May; 111(18):6834-9. PubMed ID: 24760825
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase.
    Ehrlich ES; Wang T; Luo K; Xiao Z; Niewiadomska AM; Martinez T; Xu W; Neckers L; Yu XF
    Proc Natl Acad Sci U S A; 2009 Dec; 106(48):20330-5. PubMed ID: 19933325
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Gold nanoparticles loaded with cullin-5 DNA increase sensitivity to 17-AAG in cullin-5 deficient breast cancer cells.
    Talamantez-Lyburn S; Brown P; Hondrogiannis N; Ratliff J; Wicks SL; Nana N; Zheng Z; Rosenzweig Z; Hondrogiannis E; Devadas MS; Ehrlich ES
    Int J Pharm; 2019 Jun; 564():281-292. PubMed ID: 30999048
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Regulation of Ubiquitin-like with Plant Homeodomain and RING Finger Domain 1 (UHRF1) Protein Stability by Heat Shock Protein 90 Chaperone Machinery.
    Ding G; Chen P; Zhang H; Huang X; Zang Y; Li J; Li J; Wong J
    J Biol Chem; 2016 Sep; 291(38):20125-35. PubMed ID: 27489107
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Silencing of HSP90 cochaperone AHA1 expression decreases client protein activation and increases cellular sensitivity to the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin.
    Holmes JL; Sharp SY; Hobbs S; Workman P
    Cancer Res; 2008 Feb; 68(4):1188-97. PubMed ID: 18281495
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Molecular mechanism of 17-allylamino-17-demethoxygeldanamycin (17-AAG)-induced AXL receptor tyrosine kinase degradation.
    Krishnamoorthy GP; Guida T; Alfano L; Avilla E; Santoro M; Carlomagno F; Melillo RM
    J Biol Chem; 2013 Jun; 288(24):17481-94. PubMed ID: 23629654
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression.
    Schulz R; Marchenko ND; Holembowski L; Fingerle-Rowson G; Pesic M; Zender L; Dobbelstein M; Moll UM
    J Exp Med; 2012 Feb; 209(2):275-89. PubMed ID: 22271573
    [TBL] [Abstract][Full Text] [Related]  

  • 8. HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients.
    Li Z; Zhou L; Prodromou C; Savic V; Pearl LH
    Cell Rep; 2017 Jun; 19(12):2515-2528. PubMed ID: 28636940
    [TBL] [Abstract][Full Text] [Related]  

  • 9. CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation.
    Kostrhon S; Prabu JR; Baek K; Horn-Ghetko D; von Gronau S; Klügel M; Basquin J; Alpi AF; Schulman BA
    Nat Chem Biol; 2021 Oct; 17(10):1075-1083. PubMed ID: 34518685
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Silencing the cochaperone CDC37 destabilizes kinase clients and sensitizes cancer cells to HSP90 inhibitors.
    Smith JR; Clarke PA; de Billy E; Workman P
    Oncogene; 2009 Jan; 28(2):157-69. PubMed ID: 18931700
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants.
    Prince TL; Kijima T; Tatokoro M; Lee S; Tsutsumi S; Yim K; Rivas C; Alarcon S; Schwartz H; Khamit-Kush K; Scroggins BT; Beebe K; Trepel JB; Neckers L
    PLoS One; 2015; 10(10):e0141786. PubMed ID: 26517842
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Biophysical studies on interactions and assembly of full-size E3 ubiquitin ligase: suppressor of cytokine signaling 2 (SOCS2)-elongin BC-cullin 5-ring box protein 2 (RBX2).
    Bulatov E; Martin EM; Chatterjee S; Knebel A; Shimamura S; Konijnenberg A; Johnson C; Zinn N; Grandi P; Sobott F; Ciulli A
    J Biol Chem; 2015 Feb; 290(7):4178-91. PubMed ID: 25505247
    [TBL] [Abstract][Full Text] [Related]  

  • 13. ErbB2 degradation mediated by the co-chaperone protein CHIP.
    Zhou P; Fernandes N; Dodge IL; Reddi AL; Rao N; Safran H; DiPetrillo TA; Wazer DE; Band V; Band H
    J Biol Chem; 2003 Apr; 278(16):13829-37. PubMed ID: 12574167
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells.
    Li D; Marchenko ND; Schulz R; Fischer V; Velasco-Hernandez T; Talos F; Moll UM
    Mol Cancer Res; 2011 May; 9(5):577-88. PubMed ID: 21478269
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Triad3A regulates ubiquitination and proteasomal degradation of RIP1 following disruption of Hsp90 binding.
    Fearns C; Pan Q; Mathison JC; Chuang TH
    J Biol Chem; 2006 Nov; 281(45):34592-600. PubMed ID: 16968706
    [TBL] [Abstract][Full Text] [Related]  

  • 16. HDAC6 inhibition enhances 17-AAG--mediated abrogation of hsp90 chaperone function in human leukemia cells.
    Rao R; Fiskus W; Yang Y; Lee P; Joshi R; Fernandez P; Mandawat A; Atadja P; Bradner JE; Bhalla K
    Blood; 2008 Sep; 112(5):1886-93. PubMed ID: 18591380
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Osmotic and heat stress-dependent regulation of MLK4β and MLK3 by the CHIP E3 ligase in ovarian cancer cells.
    Blessing NA; Kasturirangan S; Zink EM; Schroyer AL; Chadee DN
    Cell Signal; 2017 Nov; 39():66-73. PubMed ID: 28757353
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Characterization of Cullin-box sequences that direct recruitment of Cul2-Rbx1 and Cul5-Rbx2 modules to Elongin BC-based ubiquitin ligases.
    Mahrour N; Redwine WB; Florens L; Swanson SK; Martin-Brown S; Bradford WD; Staehling-Hampton K; Washburn MP; Conaway RC; Conaway JW
    J Biol Chem; 2008 Mar; 283(12):8005-13. PubMed ID: 18187417
    [TBL] [Abstract][Full Text] [Related]  

  • 19. UBR1 promotes protein kinase quality control and sensitizes cells to Hsp90 inhibition.
    Sultana R; Theodoraki MA; Caplan AJ
    Exp Cell Res; 2012 Jan; 318(1):53-60. PubMed ID: 21983172
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Gossypol inhibits cullin neddylation by targeting SAG-CUL5 and RBX1-CUL1 complexes.
    Yu Q; Hu Z; Shen Y; Jiang Y; Pan P; Hou T; Pan ZQ; Huang J; Sun Y
    Neoplasia; 2020 Apr; 22(4):179-191. PubMed ID: 32145688
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.