BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

277 related articles for article (PubMed ID: 24760825)

  • 1. E3 ubiquitin ligase Cullin-5 modulates multiple molecular and cellular responses to heat shock protein 90 inhibition in human cancer cells.
    Samant RS; Clarke PA; Workman P
    Proc Natl Acad Sci U S A; 2014 May; 111(18):6834-9. PubMed ID: 24760825
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase.
    Ehrlich ES; Wang T; Luo K; Xiao Z; Niewiadomska AM; Martinez T; Xu W; Neckers L; Yu XF
    Proc Natl Acad Sci U S A; 2009 Dec; 106(48):20330-5. PubMed ID: 19933325
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Gold nanoparticles loaded with cullin-5 DNA increase sensitivity to 17-AAG in cullin-5 deficient breast cancer cells.
    Talamantez-Lyburn S; Brown P; Hondrogiannis N; Ratliff J; Wicks SL; Nana N; Zheng Z; Rosenzweig Z; Hondrogiannis E; Devadas MS; Ehrlich ES
    Int J Pharm; 2019 Jun; 564():281-292. PubMed ID: 30999048
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Regulation of Ubiquitin-like with Plant Homeodomain and RING Finger Domain 1 (UHRF1) Protein Stability by Heat Shock Protein 90 Chaperone Machinery.
    Ding G; Chen P; Zhang H; Huang X; Zang Y; Li J; Li J; Wong J
    J Biol Chem; 2016 Sep; 291(38):20125-35. PubMed ID: 27489107
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Silencing of HSP90 cochaperone AHA1 expression decreases client protein activation and increases cellular sensitivity to the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin.
    Holmes JL; Sharp SY; Hobbs S; Workman P
    Cancer Res; 2008 Feb; 68(4):1188-97. PubMed ID: 18281495
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Molecular mechanism of 17-allylamino-17-demethoxygeldanamycin (17-AAG)-induced AXL receptor tyrosine kinase degradation.
    Krishnamoorthy GP; Guida T; Alfano L; Avilla E; Santoro M; Carlomagno F; Melillo RM
    J Biol Chem; 2013 Jun; 288(24):17481-94. PubMed ID: 23629654
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression.
    Schulz R; Marchenko ND; Holembowski L; Fingerle-Rowson G; Pesic M; Zender L; Dobbelstein M; Moll UM
    J Exp Med; 2012 Feb; 209(2):275-89. PubMed ID: 22271573
    [TBL] [Abstract][Full Text] [Related]  

  • 8. HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients.
    Li Z; Zhou L; Prodromou C; Savic V; Pearl LH
    Cell Rep; 2017 Jun; 19(12):2515-2528. PubMed ID: 28636940
    [TBL] [Abstract][Full Text] [Related]  

  • 9. CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation.
    Kostrhon S; Prabu JR; Baek K; Horn-Ghetko D; von Gronau S; Klügel M; Basquin J; Alpi AF; Schulman BA
    Nat Chem Biol; 2021 Oct; 17(10):1075-1083. PubMed ID: 34518685
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Silencing the cochaperone CDC37 destabilizes kinase clients and sensitizes cancer cells to HSP90 inhibitors.
    Smith JR; Clarke PA; de Billy E; Workman P
    Oncogene; 2009 Jan; 28(2):157-69. PubMed ID: 18931700
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants.
    Prince TL; Kijima T; Tatokoro M; Lee S; Tsutsumi S; Yim K; Rivas C; Alarcon S; Schwartz H; Khamit-Kush K; Scroggins BT; Beebe K; Trepel JB; Neckers L
    PLoS One; 2015; 10(10):e0141786. PubMed ID: 26517842
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Biophysical studies on interactions and assembly of full-size E3 ubiquitin ligase: suppressor of cytokine signaling 2 (SOCS2)-elongin BC-cullin 5-ring box protein 2 (RBX2).
    Bulatov E; Martin EM; Chatterjee S; Knebel A; Shimamura S; Konijnenberg A; Johnson C; Zinn N; Grandi P; Sobott F; Ciulli A
    J Biol Chem; 2015 Feb; 290(7):4178-91. PubMed ID: 25505247
    [TBL] [Abstract][Full Text] [Related]  

  • 13. ErbB2 degradation mediated by the co-chaperone protein CHIP.
    Zhou P; Fernandes N; Dodge IL; Reddi AL; Rao N; Safran H; DiPetrillo TA; Wazer DE; Band V; Band H
    J Biol Chem; 2003 Apr; 278(16):13829-37. PubMed ID: 12574167
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells.
    Li D; Marchenko ND; Schulz R; Fischer V; Velasco-Hernandez T; Talos F; Moll UM
    Mol Cancer Res; 2011 May; 9(5):577-88. PubMed ID: 21478269
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Triad3A regulates ubiquitination and proteasomal degradation of RIP1 following disruption of Hsp90 binding.
    Fearns C; Pan Q; Mathison JC; Chuang TH
    J Biol Chem; 2006 Nov; 281(45):34592-600. PubMed ID: 16968706
    [TBL] [Abstract][Full Text] [Related]  

  • 16. HDAC6 inhibition enhances 17-AAG--mediated abrogation of hsp90 chaperone function in human leukemia cells.
    Rao R; Fiskus W; Yang Y; Lee P; Joshi R; Fernandez P; Mandawat A; Atadja P; Bradner JE; Bhalla K
    Blood; 2008 Sep; 112(5):1886-93. PubMed ID: 18591380
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Osmotic and heat stress-dependent regulation of MLK4β and MLK3 by the CHIP E3 ligase in ovarian cancer cells.
    Blessing NA; Kasturirangan S; Zink EM; Schroyer AL; Chadee DN
    Cell Signal; 2017 Nov; 39():66-73. PubMed ID: 28757353
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Characterization of Cullin-box sequences that direct recruitment of Cul2-Rbx1 and Cul5-Rbx2 modules to Elongin BC-based ubiquitin ligases.
    Mahrour N; Redwine WB; Florens L; Swanson SK; Martin-Brown S; Bradford WD; Staehling-Hampton K; Washburn MP; Conaway RC; Conaway JW
    J Biol Chem; 2008 Mar; 283(12):8005-13. PubMed ID: 18187417
    [TBL] [Abstract][Full Text] [Related]  

  • 19. UBR1 promotes protein kinase quality control and sensitizes cells to Hsp90 inhibition.
    Sultana R; Theodoraki MA; Caplan AJ
    Exp Cell Res; 2012 Jan; 318(1):53-60. PubMed ID: 21983172
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Gossypol inhibits cullin neddylation by targeting SAG-CUL5 and RBX1-CUL1 complexes.
    Yu Q; Hu Z; Shen Y; Jiang Y; Pan P; Hou T; Pan ZQ; Huang J; Sun Y
    Neoplasia; 2020 Apr; 22(4):179-191. PubMed ID: 32145688
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.